Smyd1 SET and MYND domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Smyd1provided by MGI
Official Full Name: SET and MYND domain containing 1provided by MGI
Primary source: MGI:MGI:104790
See related: Ensembl:ENSMUSG00000055027 AllianceGenome:MGI:104790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bop; Zmynd18; 4632404M21Rik
Summary: Enables transcription corepressor activity. Acts upstream of or within several processes, including chromatin remodeling; negative regulation of DNA-templated transcription; and skeletal muscle cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; heart; maxillary process; and spleen. Orthologous to human SMYD1 (SET and MYND domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in heart adult (RPKM 89.8), mammary gland adult (RPKM 9.3) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.14 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (71190924..71239265, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (71213940..71262281, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The histone methyltransferase SMYD1 is induced by thermogenic stimuli in adipose tissue.
Title: The histone methyltransferase SMYD1 is induced by thermogenic stimuli in adipose tissue.
Resistance training up-regulates Smyd1 expression and inhibits oxidative stress and endoplasmic reticulum stress in the heart of middle-aged mice.
Title: Resistance training up-regulates Smyd1 expression and inhibits oxidative stress and endoplasmic reticulum stress in the heart of middle-aged mice.
Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.
Title: Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.
SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation.
Title: SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation.
Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1.
Title: Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1.
The data suggest that skNAC and Smyd1 might be major players in the processes of myofibrillogenesis and sarcomerogenesis, probably specifically at later stages.
Title: siRNA-mediated inhibition of skNAC and Smyd1 expression disrupts myofibril organization: Immunofluorescence and electron microscopy study in C2C12 cells.
These findings provide functional evidence for a role of Smyd1, or any member of the Smyd family, in regulating cardiac energetics in the adult heart, which is mediated, at least in part, via modulating PGC-1alpha.
Title: Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart.
Smyd1 is responsible for restricting growth in the adult heart, with its absence leading to cellular hypertrophy, organ remodeling, and fulminate heart failure. Molecular studies reveal Smyd1 to be a muscle-specific regulator of gene expression and indicate that Smyd1 modulates expression of gene isoforms whose expression is associated with cardiac pathology. Activation of Smyd1 can prevent pathological cell growth.
Title: The chromatin-binding protein Smyd1 restricts adult mammalian heart growth.
This work illustrates a crucial role for SMYD1 in skeletal muscle physiology and myofibril integrity.
Title: Mouse myofibers lacking the SMYD1 methyltransferase are susceptible to atrophy, internalization of nuclei and myofibrillar disarray.
Deletion of Smyd1 impaired myoblast differentiation, resulted in fewer myofibers and decreased expression of muscle-specific genes
Title: Defective myogenesis in the absence of the muscle-specific lysine methyltransferase SMYD1.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone H3K4 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin remodeling	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myotube differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone-lysine N-methyltransferase Smyd1

Names: CD8b-opposite; CD8beta opposite strand; SET and MYND domain-containing protein 1; m-BOP; zinc finger protein BOP

NP_001153599.1

EC 2.1.1.354

NP_033892.2

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160127.1 → NP_001153599.1 histone-lysine N-methyltransferase Smyd1 isoform 1

See identical proteins and their annotated locations for NP_001153599.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC076601, BY089666

Consensus CDS

CCDS51805.1

UniProtKB/Swiss-Prot

P97442, P97443, P97444, Q6DFW7

UniProtKB/TrEMBL

G5E8R7

Related

ENSMUSP00000073911.4, ENSMUST00000074301.10

Conserved Domains (2) summary

cd10526
Location:7 → 281

SET_SMYD1; SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins

pfam01753
Location:52 → 90

zf-MYND; MYND finger
NM_009762.2 → NP_033892.2 histone-lysine N-methyltransferase Smyd1 isoform 2

See identical proteins and their annotated locations for NP_033892.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AK142153, BC076601, BY089666

Consensus CDS

CCDS20227.2

UniProtKB/TrEMBL

G5E8R7, Q3UQT9

Related

ENSMUSP00000109824.3, ENSMUST00000114186.9

Conserved Domains (2) summary

smart00317
Location:194 → 244

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam01753
Location:52 → 90

zf-MYND; MYND finger