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    NPIPB2 nuclear pore complex interacting protein family member B2 [ Homo sapiens (human) ]

    Gene ID: 729978, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NPIPB2provided by HGNC
    Official Full Name
    nuclear pore complex interacting protein family member B2provided by HGNC
    Primary source
    HGNC:HGNC:37451
    See related
    Ensembl:ENSG00000234719 AllianceGenome:HGNC:37451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NPIPB2 in Genome Data Viewer
    Location:
    16p13.13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11927263..11976643, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11963311..12012756, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (12021120..12070500, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11932294-11932479 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:11944561-11945760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11946068-11946601 Neighboring gene ribosomal L1 domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7212 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:12009257-12010194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12011253-12011753 Neighboring gene G1 to S phase transition 1 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12066613-12067113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:12069255-12069906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7216 Neighboring gene TNF receptor superfamily member 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10463 Neighboring gene ubiquitin like 5 pseudogene 4 Neighboring gene sorting nexin 29 Neighboring gene Sharpr-MPRA regulatory region 15429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:12169236-12169786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7217 Neighboring gene uncharacterized LOC642696 Neighboring gene ribosomal protein S23 pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2 alpha. Saiga A, et al. Prostaglandins Other Lipid Mediat, 2005 Jan. PMID 15789617
    2. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. sPLA2-X induces potent arachidonic acid release without activation of cytosolic phospholipase A2 alpha.
      Title: Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2 alpha.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative nuclear pore complex-interacting protein family member B2
    Names
    putative NPIP-like protein LOC729978

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355514.1 → NP_001342443.1  putative nuclear pore complex-interacting protein family member B2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC007216
      Conserved Domains (1) summary
      pfam06409
      Location:1 → 125
      NPIP; Nuclear pore complex interacting protein (NPIP)

    2. NM_001395852.1 → NP_001382781.1  putative nuclear pore complex-interacting protein family member B2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC007216
      Conserved Domains (1) summary
      pfam06409
      Location:1 → 125
      NPIP; Nuclear pore complex interacting protein (NPIP)

    3. NM_001395853.1 → NP_001382782.1  putative nuclear pore complex-interacting protein family member B2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC007216
      Conserved Domains (1) summary
      pfam06409
      Location:1 → 125
      NPIP; Nuclear pore complex interacting protein (NPIP)

    4. NM_001395854.1 → NP_001382783.1  putative nuclear pore complex-interacting protein family member B2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC007216
      Consensus CDS
      CCDS92109.1
      UniProtKB/TrEMBL
      A0A5F9ZI19
      Related
      ENSP00000500799.1, ENST00000673243.1

    5. NM_001395855.1 → NP_001382784.1  putative nuclear pore complex-interacting protein family member B2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC007216
      Consensus CDS
      CCDS92109.1
      UniProtKB/TrEMBL
      A0A5F9ZI19

    6. NM_001396485.1 → NP_001383414.1  putative nuclear pore complex-interacting protein family member B2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC007216
      Consensus CDS
      CCDS92110.1
      UniProtKB/Swiss-Prot
      A0A0A6YYH2, A6NJ64, J3KPX4
      UniProtKB/TrEMBL
      F8VY45
      Related
      ENSP00000382101.4, ENST00000399147.8
      Conserved Domains (2) summary
      PTZ00449
      Location:290 → 389
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam06409
      Location:27 → 299
      NPIP; Nuclear pore complex interacting protein (NPIP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      11927263..11976643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434580.1 → XP_047290536.1  putative nuclear pore complex-interacting protein family member B2 isoform X2

    2. XM_047434579.1 → XP_047290535.1  putative nuclear pore complex-interacting protein family member B2 isoform X1

      UniProtKB/TrEMBL
      A0A8V8TLJ1

    3. XM_047434581.1 → XP_047290537.1  putative nuclear pore complex-interacting protein family member B2 isoform X5

      UniProtKB/TrEMBL
      F8VY45

    4. XM_024450431.1 → XP_024306199.1  putative nuclear pore complex-interacting protein family member B2 isoform X4

      Conserved Domains (1) summary
      pfam06409
      Location:1 → 125
      NPIP; Nuclear pore complex interacting protein (NPIP)

    5. XM_024450429.2 → XP_024306197.1  putative nuclear pore complex-interacting protein family member B2 isoform X3

      Conserved Domains (1) summary
      pfam06409
      Location:1 → 101
      NPIP; Nuclear pore complex interacting protein (NPIP)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      11963311..12012756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_012736.2: Suppressed sequence

      Description
      NG_012736.2: This RefSeq was removed because it is now thought that this locus encodes a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NJ64.4 GenPept UniProtKB/Swiss-Prot:A6NJ64

    Gene LinkOut

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    Research Materials