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    PGR progesterone receptor [ Homo sapiens (human) ]

    Gene ID: 5241, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PGRprovided by HGNC
    Official Full Name
    progesterone receptorprovided by HGNC
    Primary source
    HGNC:HGNC:8910
    See related
    Ensembl:ENSG00000082175 MIM:607311; AllianceGenome:HGNC:8910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR; NR3C3
    Summary
    This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in endometrium (RPKM 46.4) and ovary (RPKM 5.5) See more
    Orthologs
    mouse all
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    Genomic context

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    See PGR in Genome Data Viewer
    Location:
    11q22.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (101029624..101129813, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (101039187..101139328, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (100900355..101000544, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 42 Neighboring gene uncharacterized LOC105369457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5431 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18463 Neighboring gene Sharpr-MPRA regulatory region 5256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5432 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18498 Neighboring gene small nucleolar RNA, C/D box 13I Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:100848900-100849468 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:100849469-100850035 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:100953401-100953965 Neighboring gene MPRA-validated peak1438 silencer Neighboring gene PGR antisense RNA 1 Neighboring gene MTMR12 pseudogene 1 Neighboring gene uncharacterized LOC105369458

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The knockdown of progesterone receptor isoform B (PR-B) promotes proliferation in immortalized endometrial stromal cells. Wu Y, et al. Fertil Steril, 2008 Oct. PMID 18249378
    2. Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women. Ho HP, et al. Psychoneuroendocrinology, 2004 Oct. PMID 15219637
    3. No association between the progesterone receptor gene +331G/A polymorphism and breast cancer. Feigelson HS, et al. Cancer Epidemiol Biomarkers Prev, 2004 Jun. PMID 15184270
    4. Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach. Lee E, et al. Carcinogenesis, 2010 Aug. PMID 20547493, Free PMC Article
    5. Expression and cellular localization of the classical progesterone receptor in healthy and amyotrophic lateral sclerosis affected spinal cord. Gargiulo-Monachelli GM, et al. Eur J Neurol, 2014 Feb. PMID 24894997

    See all (793) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Progesterone receptor distribution in the human hypothalamus and its association with suicide.
      Title: Progesterone receptor distribution in the human hypothalamus and its association with suicide.
    2. Progesterone and cAMP synergistically induce SHP2 expression via PGR and CREB1 during uterine stromal decidualization.
      Title: Progesterone and cAMP synergistically induce SHP2 expression via PGR and CREB1 during uterine stromal decidualization.
    3. USP7 promotes decidualization of ESCs by STAT3/PR axis during early pregnancy.
      Title: USP7 promotes decidualization of ESCs by STAT3/PR axis during early pregnancy.
    4. The role of progesterone receptor isoforms in the myometrium.
      Title: The role of progesterone receptor isoforms in the myometrium.
    5. Progesterone receptor expression and prediction of benefits of adjuvant radiotherapy in de novo atypical meningiomas after gross-total resection.
      Title: Progesterone receptor expression and prediction of benefits of adjuvant radiotherapy in de novo atypical meningiomas after gross-total resection.
    6. Association of Val660Leu, progesterone receptor polymorphic variant, with susceptibility to RRMS disease.
      Title: Association of Val660Leu, progesterone receptor polymorphic variant, with susceptibility to RRMS disease.
    7. Malignancy risk factors and prognostic variables of pancreatic mucinous cystic neoplasms in Chinese patients.
      Title: Malignancy risk factors and prognostic variables of pancreatic mucinous cystic neoplasms in Chinese patients.
    8. PRB inhibited cell proliferation through let-7b-E2F1 in breast cancer.
      Title: PRB inhibited cell proliferation through let-7b-E2F1 in breast cancer.
    9. A prospective cohort study of clinical characteristics and outcomes in Chinese patients with estrogen receptor-negative/progesterone receptor-positive early breast cancer.
      Title: A prospective cohort study of clinical characteristics and outcomes in Chinese patients with estrogen receptor-negative/progesterone receptor-positive early breast cancer.
    10. Interferon-gamma is quintessential for NOS2 and COX2 expression in ER[-] breast tumors that lead to poor outcome.
      Title: Interferon-gamma is quintessential for NOS2 and COX2 expression in ER(-) breast tumors that lead to poor outcome.
    Submit: New GeneRIF Correction See all GeneRIFs (644)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Progesterone resistance
    MedGen: C1849699 OMIM: 264080 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables G protein-coupled receptor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables estrogen response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear steroid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glandular epithelial cell maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lung alveolus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of protein location in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nuclear receptor-mediated steroid hormone signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ovulation from ovarian follicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in paracrine signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in progesterone receptor signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in progesterone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in progesterone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tertiary branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    progesterone receptor
    Names
    nuclear receptor subfamily 3 group C member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016475.1 RefSeqGene

      Range
      5001..105190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000926.4 → NP_000917.3  progesterone receptor isoform B

      See identical proteins and their annotated locations for NP_000917.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (B).
      Source sequence(s)
      AP001533, M15716
      Consensus CDS
      CCDS8310.1
      UniProtKB/Swiss-Prot
      A7LQ08, A7X8B0, B4E3T0, P06401, Q8TDS3, Q9UPF7
      UniProtKB/TrEMBL
      Q8NG42
      Related
      ENSP00000325120.5, ENST00000325455.10
      Conserved Domains (3) summary
      cd07074
      Location:686 → 933
      NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
      cd07172
      Location:563 → 640
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02161
      Location:1 → 564
      Prog_receptor; Progesterone receptor

    2. NM_001202474.3 → NP_001189403.1  progesterone receptor isoform A

      Status: REVIEWED

      Source sequence(s)
      AP001533, M15716
      UniProtKB/Swiss-Prot
      P06401
      Conserved Domains (3) summary
      cd07074
      Location:522 → 769
      NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
      cd07172
      Location:399 → 476
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02161
      Location:1 → 400
      Prog_receptor; Progesterone receptor

    3. NM_001271161.2 → NP_001258090.1  progesterone receptor isoform C

      Status: REVIEWED

      Source sequence(s)
      AB084248, AP001533
      UniProtKB/Swiss-Prot
      P06401
      Related
      ENSP00000263463.5, ENST00000263463.9
      Conserved Domains (3) summary
      cd07172
      Location:399 → 475
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02161
      Location:1 → 400
      Prog_receptor; Progesterone receptor
      cl11397
      Location:470 → 667
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    4. NM_001271162.2 → NP_001258091.1  progesterone receptor isoform D

      See identical proteins and their annotated locations for NP_001258091.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) represents an alternate first exon, compared to variant 1, resulting in a protein isoform (D) with a shorter N-terminus.
      Source sequence(s)
      AK304853, AP001533
      Consensus CDS
      CCDS59229.1
      UniProtKB/Swiss-Prot
      P06401
      Related
      ENSP00000436561.1, ENST00000534013.5
      Conserved Domains (2) summary
      cd07074
      Location:92 → 339
      NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
      cl02596
      Location:1 → 46
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    RNA

    1. NR_073141.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and represents use of an alternate splice acceptor site, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.
      Source sequence(s)
      AB085845, AP001533

    2. NR_073142.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents use of an alternate splice acceptor site, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.
      Source sequence(s)
      AB085843, AP001533

    3. NR_073143.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) omits two coding exons, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.
      Source sequence(s)
      AB085683, AP001533

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      101029624..101129813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006718858.4 → XP_006718921.1  progesterone receptor isoform X1

      UniProtKB/TrEMBL
      Q8NG42
      Related
      ENSP00000432352.1, ENST00000534780.5
      Conserved Domains (3) summary
      cd07172
      Location:563 → 640
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02161
      Location:1 → 564
      Prog_receptor; Progesterone receptor
      cl11397
      Location:686 → 786
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    2. XM_011542869.3 → XP_011541171.1  progesterone receptor isoform X2

      UniProtKB/TrEMBL
      Q8NG43
      Conserved Domains (2) summary
      pfam02161
      Location:1 → 564
      Prog_receptor; Progesterone receptor
      cl02596
      Location:563 → 596
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      101039187..101139328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369129.1 → XP_054225104.1  progesterone receptor isoform X1

      UniProtKB/TrEMBL
      Q8NG42

    2. XM_054369130.1 → XP_054225105.1  progesterone receptor isoform X2

      UniProtKB/TrEMBL
      Q8NG43
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06401.4 GenPept UniProtKB/Swiss-Prot:P06401

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