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    MOD1 NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815152, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MOD1
    Official Full Name
    NAD(P)-binding Rossmann-fold superfamily protein
    Primary source
    TAIR:AT2G05990
    Locus tag
    AT2G05990
    See related
    Araport:AT2G05990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ENOYL-ACP REDUCTASE; ENOYL-ACP REDUCTASE 1; ENR1; MOSAIC DEATH 1; T6P5.19; T6P5_19
    Summary
    Encodes enoyl-ACP reductase a component of the fatty acid synthase complex. A reduced function mutation in this gene, mod1, was found in a screen for premature cell death mutants. Mutant plants have reduced lipid level and pleiotropic morphological defects, including chlorotic and abnormally shaped leaves.
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    Genomic context

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    See MOD1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (2322215..2325197)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A pathogenic fungi diphenyl ether phytotoxin targets plant enoyl (acyl carrier protein) reductase. Dayan FE, et al. Plant Physiol, 2008 Jul. PMID 18467464, Free PMC Article
    2. Deficiency in fatty acid synthase leads to premature cell death and dramatic alterations in plant morphology. Mou Z, et al. Plant Cell, 2000 Mar. PMID 10715326, Free PMC Article
    3. Dual-Localized Enzymatic Components Constitute the Fatty Acid Synthase Systems in Mitochondria and Plastids. Guan X, et al. Plant Physiol, 2020 Jun. PMID 32245791, Free PMC Article
    4. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
    5. Central functions of the lumenal and peripheral thylakoid proteome of Arabidopsis determined by experimentation and genome-wide prediction. Peltier JB, et al. Plant Cell, 2002 Jan. PMID 11826309, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A pathogenic fungi diphenyl ether phytotoxin targets plant enoyl (acyl carrier protein) reductase.
      Title: A pathogenic fungi diphenyl ether phytotoxin targets plant enoyl (acyl carrier protein) reductase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_126612.3
    NM_179609.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding HDA PubMed 
    enables enoyl-[acyl-carrier-protein] reductase (NADH) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    part_of fatty acid synthase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in thylakoid HDA PubMed 

    General protein information

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    Preferred Names
    NAD(P)-binding Rossmann-fold superfamily protein
    NP_565331.1
    • MOSAIC DEATH 1 (MOD1); FUNCTIONS IN: enoyl-[acyl-carrier-protein] reductase (NADH) activity, oxidoreductase activity, enoyl-[acyl-carrier-protein] reductase activity, copper ion binding; INVOLVED IN: fatty acid biosynthetic process; LOCATED IN: fatty acid synthase complex, thylakoid, chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198), Enoyl-[acyl-carrier-protein] reductase (NADH) (InterPro:IPR014358); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT2G29260.1); Has 34697 Blast hits to 34681 proteins in 2732 species: Archae - 268; Bacteria - 25258; Metazoa - 667; Fungi - 643; Plants - 667; Viruses - 0; Other Eukaryotes - 7194 (source: NCBI BLink).
    NP_849940.1
    • MOSAIC DEATH 1 (MOD1); FUNCTIONS IN: enoyl-[acyl-carrier-protein] reductase (NADH) activity, oxidoreductase activity, enoyl-[acyl-carrier-protein] reductase activity, copper ion binding; INVOLVED IN: fatty acid biosynthetic process; LOCATED IN: fatty acid synthase complex, thylakoid, chloroplast, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198), Enoyl-[acyl-carrier-protein] reductase (NADH) (InterPro:IPR014358); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT2G29260.1); Has 34697 Blast hits to 34681 proteins in 2732 species: Archae - 268; Bacteria - 25258; Metazoa - 667; Fungi - 643; Plants - 667; Viruses - 0; Other Eukaryotes - 7194 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      2322215..2325197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126612.3 → NP_565331.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565331.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04942, Q9FEF2, Q9M672, Q9SLA8
      UniProtKB/TrEMBL
      A0A178VTH6, A0A5S9WXF1, A0A654ETR6
      Conserved Domains (1) summary
      PLN02730
      Location:86 → 388
      PLN02730; enoyl-[acyl-carrier-protein] reductase

    2. NM_179609.1 → NP_849940.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849940.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04942, Q9FEF2, Q9M672, Q9SLA8
      UniProtKB/TrEMBL
      A0A178VTH6, A0A5S9WXF1, A0A654ETR6
      Conserved Domains (1) summary
      PLN02730
      Location:86 → 388
      PLN02730; enoyl-[acyl-carrier-protein] reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SLA8.1

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