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    BBX21 salt tolerance homolog2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843890, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BBX21
    Official Full Name
    salt tolerance homolog2
    Primary source
    TAIR:AT1G75540
    Locus tag
    AT1G75540
    See related
    Araport:AT1G75540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtBBX21; B BOX 21; B-box domain protein 21; F10A5.24; F10A5_24; LHUS; long hypocotyl under shade; salt tolerance homolog2; STH2
    Summary
    Encodes a B-box zinc finger transcription factor BBX21 (also named STH2/salt tolerance homolog2 and LHUS/long hypocotyl under shade). Interacts with COP1 to control de-etiolation. Also genetically interacts with COP1 to regulate shade avoidance.
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    Genomic context

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    See BBX21 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (28365824..28367738)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Forkhead-associated (FHA) domain-containing protein Neighboring gene glycine-rich protein Neighboring gene zinc knuckle (CCHC-type) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterologous Expression of AtBBX21 Enhances the Rate of Photosynthesis and Alleviates Photoinhibition in Solanumtuberosum. Crocco CD, et al. Plant Physiol, 2018 May. PMID 29555784, Free PMC Article
    2. The B-Box Domain Protein BBX21 Promotes Photomorphogenesis. Xu D, et al. Plant Physiol, 2018 Mar. PMID 29259103, Free PMC Article
    3. Function of B-BOX under shade. Crocco CD, et al. Plant Signal Behav, 2011 Jan. PMID 21301219, Free PMC Article
    4. HRB2 and BBX21 interaction modulates Arabidopsis ABI5 locus and stomatal aperture. Kang X, et al. Plant Cell Environ, 2018 Aug. PMID 29748960
    5. Convergence of Light and ABA signaling on the ABI5 promoter. Xu D, et al. PLoS Genet, 2014 Feb. PMID 24586210, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Karrikins control seedling photomorphogenesis and anthocyanin biosynthesis through a HY5-BBX transcriptional module.
      Title: Karrikins control seedling photomorphogenesis and anthocyanin biosynthesis through a HY5-BBX transcriptional module.
    2. A Positive Feedback Loop of BBX11-BBX21-HY5 Promotes Photomorphogenic Development in Arabidopsis.
      Title: A Positive Feedback Loop of BBX11-BBX21-HY5 Promotes Photomorphogenic Development in Arabidopsis.
    3. Identification of BBX proteins as rate-limiting cofactors of HY5.
      Title: Identification of BBX proteins as rate-limiting cofactors of HY5.
    4. interaction with HRB2 modulates ABI5 locus and stomatal aperture
      Title: HRB2 and BBX21 interaction modulates Arabidopsis ABI5 locus and stomatal aperture.
    5. The second B-box domain in BBX21 is indispensable for its biological function in plants. The structurally intact second B-box domain, but not the first one, is required and necessary for binding of HY5 promoter, activating HY5 expression and promoting photomorphogenesis.
      Title: The B-Box Domain Protein BBX21 Promotes Photomorphogenesis.
    6. BBX21 overexpression improved morphological and physiological attributes, and photosynthetic rates in nonoptimal, high-irradiance conditions, without associated impairment of water use efficiency.
      Title: Heterologous Expression of AtBBX21 Enhances the Rate of Photosynthesis and Alleviates Photoinhibition in Solanumtuberosum.
    7. Findings indicate that both B-Box Proteins BBX21 and BBX24 regulate ELONGATED HYPOCOTYL 5 protein (HY5) activity post-transcriptionally, in opposite ways.
      Title: Two B-Box Proteins Regulate Photomorphogenesis by Oppositely Modulating HY5 through their Diverse C-Terminal Domains.
    8. AGB1 positively promotes hypocotyl elongation through repressing BBX21 activity.
      Title: The G-Protein β Subunit AGB1 Promotes Hypocotyl Elongation through Inhibiting Transcription Activation Function of BBX21 in Arabidopsis.
    9. binds to the T/G-box in the ELONGATED HYPOCOTYL 5 (HY5) promoter and directly activates HY5 expression in the light
      Title: BBX21, an Arabidopsis B-box protein, directly activates HY5 and is targeted by COP1 for 26S proteasome-mediated degradation.
    10. our study indicates that BBX21 coordinates with HY5 and ABI5 on the ABI5 promoter and that these transcriptional regulators work in concert to integrate light and ABA signaling in Arabidopsis thaliana.
      Title: Convergence of Light and ABA signaling on the ABI5 promoter.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_106207.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within photoprotection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of photosynthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within shade avoidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within shade avoidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    salt tolerance homolog2
    NP_177686.1
    • salt tolerance homolog2 (STH2); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity, zinc ion binding; LOCATED IN: intracellular; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, B-box (InterPro:IPR000315); BEST Arabidopsis thaliana protein match is: B-box zinc finger family protein (TAIR:AT4G39070.1); Has 3177 Blast hits to 2249 proteins in 137 species: Archae - 0; Bacteria - 0; Metazoa - 20; Fungi - 43; Plants - 2068; Viruses - 0; Other Eukaryotes - 1046 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28365824..28367738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106207.4 → NP_177686.1  salt tolerance homolog2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177686.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0SV33, Q9LQZ7
      UniProtKB/TrEMBL
      A0A5S9WUM1
      Conserved Domains (1) summary
      smart00336
      Location:56 → 102
      BBOX; B-Box-type zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LQZ7.1

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