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    PHR1 photolyase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837792, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PHR1
    Official Full Name
    photolyase 1
    Primary source
    TAIR:AT1G12370
    Locus tag
    AT1G12370
    See related
    Araport:AT1G12370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F5O11.9; F5O11_9; photolyase 1; TYPE II CPD PHOTOLYASE; UV RESISTANCE 2; UVR2
    Summary
    encodes an amino acid sequence with significant homology to the recently characterized type II photolyases. The uvr2-1 mutant is unable to remove CPDs in vivo, and plant extracts lack detectable photolyase activity, is sensitive to UV-B and is an allele
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    Genomic context

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    See PHR1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (4206360..4208999, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Cornichon family protein Neighboring gene 4-phospho-panto-thenoylcysteine synthetase Neighboring gene Sec1/munc18-like (SM) proteins superfamily Neighboring gene uncharacterized protein Neighboring gene Cornichon family protein Neighboring gene Nucleotide excision repair, TFIIH, subunit TTDA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UVR2 ensures transgenerational genome stability under simulated natural UV-B in Arabidopsis thaliana. Willing EM, et al. Nat Commun, 2016 Dec 1. PMID 27905394, Free PMC Article
    2. Light-induced activation of class II cyclobutane pyrimidine dimer photolyases. Okafuji A, et al. DNA Repair (Amst), 2010 May 4. PMID 20227927
    3. Increased expression of the MYB-related transcription factor, PHR1, leads to enhanced phosphate uptake in Arabidopsis thaliana. Nilsson L, et al. Plant Cell Environ, 2007 Dec. PMID 17927693
    4. An enzyme similar to animal type II photolyases mediates photoreactivation in Arabidopsis. Ahmad M, et al. Plant Cell, 1997 Feb. PMID 9061951, Free PMC Article
    5. An Arabidopsis photolyase mutant is hypersensitive to ultraviolet-B radiation. Landry LG, et al. Proc Natl Acad Sci U S A, 1997 Jan 7. PMID 8990208, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. germline-specific UVR2 activity occurs during late flower development, and is important for ensuring low mutation rates in male and female cell lineages.
      Title: UVR2 ensures transgenerational genome stability under simulated natural UV-B in Arabidopsis thaliana.
    2. a different, but also effective, electron-transfer cascade is conserved among the class II photolyases
      Title: Light-induced activation of class II cyclobutane pyrimidine dimer photolyases.
    3. The phr1 knockout mutant has an altered phosphate allocation between root and shoot; accumulates less anthocyanins, sugars and starch than P-starved WT; has a lower AGPase activity; and is impaired in induction of a subset of Pi starvation-induced genes.
      Title: Increased expression of the MYB-related transcription factor, PHR1, leads to enhanced phosphate uptake in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001332032.1
    NM_101109.1
    NM_179320.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA photolyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deoxyribodipyrimidine photo-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within UV protection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photoreactive repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    photolyase 1
    NP_563906.1
    • photolyase 1 (PHR1); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), DNA photolyase, N-terminal (InterPro:IPR006050), DNA photolyase, FAD-binding/Cryptochrome, C-terminal (InterPro:IPR005101), DNA photolyase, class 2 (InterPro:IPR008148); Has 1792 Blast hits to 1788 proteins in 474 species: Archae - 23; Bacteria - 644; Metazoa - 122; Fungi - 53; Plants - 107; Viruses - 39; Other Eukaryotes - 804 (source: NCBI BLink).
    NP_849651.1
    • photolyase 1 (PHR1); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), DNA photolyase, N-terminal (InterPro:IPR006050), DNA photolyase, FAD-binding/Cryptochrome, C-terminal (InterPro:IPR005101), DNA photolyase, class 2 (InterPro:IPR008148); Has 2452 Blast hits to 2448 proteins in 660 species: Archae - 33; Bacteria - 979; Metazoa - 129; Fungi - 60; Plants - 123; Viruses - 39; Other Eukaryotes - 1089 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4206360..4208999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179320.2 → NP_849651.1  photolyase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849651.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O24374, Q94CC5, Q9LNA9, Q9SB00
      UniProtKB/TrEMBL
      A0A178WLR2, A0A5S9U2T1
      Conserved Domains (1) summary
      TIGR00591
      Location:5 → 467
      phr2; photolyase PhrII

    2. NM_001332032.1 → NP_001321694.1  photolyase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WLR2, A0A1P8ARP1

    3. NM_101109.1 → NP_563906.1  photolyase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563906.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WLR2
      Conserved Domains (2) summary
      TIGR00591
      Location:5 → 461
      phr2; photolyase PhrII
      pfam00875
      Location:30 → 193
      DNA_photolyase; DNA photolyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SB00.1

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