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    UBC19 ubiquitin-conjugating enzyme19 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821545, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UBC19
    Official Full Name
    ubiquitin-conjugating enzyme19
    Primary source
    TAIR:AT3G20060
    Locus tag
    AT3G20060
    See related
    Araport:AT3G20060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ubiquitin-conjugating enzyme19
    Summary
    Encodes one of two ubiquitin-conjugating enzymes belonging to the E2-C gene family (the other being UBC19). Transcript is always found in dividing cells, but also in other non-dividing cells. Protein is localized to the cytoplasm as well as to the nucleus.
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    Genomic context

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    See UBC19 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (7002697..7004508, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene Hexokinase Neighboring gene T-complex protein 1 alpha subunit Neighboring gene titan9 Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UBC19 is a new interacting protein of ORANGE for its nuclear localization in Arabidopsis thaliana. Chen WC, et al. Plant Signal Behav, 2021 Nov 2. PMID 34405771, Free PMC Article
    2. Molecular characterization of plant ubiquitin-conjugating enzymes belonging to the UbcP4/E2-C/UBCx/UbcH10 gene family. Criqui MC, et al. Plant Physiol, 2002 Nov. PMID 12427990, Free PMC Article
    3. LOWER TEMPERATURE 1 Enhances ABA Responses and Plant Drought Tolerance by Modulating the Stability and Localization of C2-Domain ABA-Related Proteins in Arabidopsis. Qin T, et al. Mol Plant, 2019 Sep 2. PMID 31102784
    4. Genome analysis and functional characterization of the E2 and RING-type E3 ligase ubiquitination enzymes of Arabidopsis. Kraft E, et al. Plant Physiol, 2005 Dec. PMID 16339806, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084723.1
    NM_112897.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein targeting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_negative_effect response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme19
    NP_001078192.1
    • ubiquitin-conjugating enzyme19 (UBC19); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme E2 H10 (InterPro:IPR015582), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 20 (TAIR:AT1G50490.1); Has 9466 Blast hits to 9449 proteins in 390 species: Archae - 0; Bacteria - 0; Metazoa - 4186; Fungi - 1966; Plants - 1712; Viruses - 20; Other Eukaryotes - 1582 (source: NCBI BLink).
    NP_566653.1
    • ubiquitin-conjugating enzyme19 (UBC19); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme E2 H10 (InterPro:IPR015582), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 20 (TAIR:AT1G50490.1); Has 2436 Blast hits to 2429 proteins in 193 species: Archae - 0; Bacteria - 0; Metazoa - 552; Fungi - 119; Plants - 1682; Viruses - 0; Other Eukaryotes - 83 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7002697..7004508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112897.4 → NP_566653.1  ubiquitin-conjugating enzyme19 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566653.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MSD2, Q9LJZ5
      UniProtKB/TrEMBL
      A0A178V7W3, A0A5S9XDU0
      Conserved Domains (1) summary
      pfam00179
      Location:40 → 176
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_001084723.1 → NP_001078192.1  ubiquitin-conjugating enzyme19 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078192.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WIZ7
      Conserved Domains (2) summary
      COG5078
      Location:3 → 132
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:3 → 131
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LJZ5.1

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