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    UPM1 urophorphyrin methylase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834085, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UPM1
    Official Full Name
    urophorphyrin methylase 1
    Primary source
    TAIR:AT5G40850
    Locus tag
    AT5G40850
    See related
    Araport:AT5G40850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MHK7.8; MHK7_8; urophorphyrin methylase 1
    Summary
    Encodes a urophorphyrin III methylase that catalyzes S-adenosyl-L-methionine-dependent transmethylation in a multistep process involving the formation of a covalently linked complex with S-adenosyl-L-methionine.
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    Genomic context

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    See UPM1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (16365900..16369316)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene Rad21/Rec8-like family protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uridine kinase/uracil phosphoribosyltransferase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alleviation of Nitrogen and Sulfur Deficiency and Enhancement of Photosynthesis in Arabidopsis thaliana by Overexpression of Uroporphyrinogen III Methyltransferase (UPM1). Garai S, et al. Front Plant Sci, 2017. PMID 29472934, Free PMC Article
    2. Phylogenetic analysis and photoregulation of siroheme biosynthesis genes: uroporphyrinogen III methyltransferase and sirohydrochlorin ferrochelatase of Arabidopsis thaliana. Garai S, et al. Physiol Mol Biol Plants, 2016 Jul. PMID 27729721, Free PMC Article
    3. Gene expression profiling of the tetrapyrrole metabolic pathway in Arabidopsis with a mini-array system. Matsumoto F, et al. Plant Physiol, 2004 Aug. PMID 15326282, Free PMC Article
    4. Siroheme biosynthesis in higher plants. Analysis of an S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase from Arabidopsis thaliana. Leustek T, et al. J Biol Chem, 1997 Jan 31. PMID 9006913
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001203515.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables uroporphyrin-III C-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of chlorophyll biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nitrate assimilation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of sulfate assimilation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within siroheme biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in siroheme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    urophorphyrin methylase 1
    NP_001190444.1
    • urophorphyrin methylase 1 (UPM1); CONTAINS InterPro DOMAIN/s: Tetrapyrrole methylase (InterPro:IPR000878), Tetrapyrrole methylase, subdomain 1 (InterPro:IPR014777), Uroporphyrin-III C-methyltransferase, C-terminal (InterPro:IPR006366), Tetrapyrrole methylase, subdomain 2 (InterPro:IPR014776), Uroporphiryn-III C-methyltransferase, conserved site (InterPro:IPR003043).
    NP_198901.1
    • urophorphyrin methylase 1 (UPM1); CONTAINS InterPro DOMAIN/s: Tetrapyrrole methylase (InterPro:IPR000878), Tetrapyrrole methylase, subdomain 1 (InterPro:IPR014777), Uroporphyrin-III C-methyltransferase, plant (InterPro:IPR012383), Uroporphyrin-III C-methyltransferase, C-terminal (InterPro:IPR006366), Tetrapyrrole methylase, subdomain 2 (InterPro:IPR014776), Uroporphiryn-III C-methyltransferase, conserved site (InterPro:IPR003043); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16365900..16369316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123450.5 → NP_198901.1  urophorphyrin methylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198901.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42606, Q96532
      UniProtKB/TrEMBL
      A0A178UEZ5, A0A5S9YC46
      Conserved Domains (1) summary
      PLN02625
      Location:82 → 363
      PLN02625; uroporphyrin-III C-methyltransferase

    2. NM_001344363.1 → NP_001331463.1  urophorphyrin methylase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BE13

    3. NM_001203515.1 → NP_001190444.1  urophorphyrin methylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190444.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UEZ5, A0A5S9YC46, F4KIS7
      Conserved Domains (1) summary
      PLN02625
      Location:82 → 325
      PLN02625; uroporphyrin-III C-methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42606.1

    Gene LinkOut

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