U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RING1A RING 1A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834451, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RING1A
    Official Full Name
    RING 1A
    Primary source
    TAIR:AT5G44280
    Locus tag
    AT5G44280
    See related
    Araport:AT5G44280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA RING 1A; ATRING1A; K9L2.3; K9L2_3; RING 1A
    Summary
    Encodes a nuclear localized protein with similarity to animal polycomb repressive core complex1 (PRC1) core component RING.Appears to function redundantly with ATRING1b, a close paralog. Both interact physically with CLF and LHP1 and appear to function together to repress class I KNOX gene expression.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RING1A in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (17835810..17839303, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Zinc finger C-x8-C-x5-C-x3-H type family protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene TPX2 (targeting protein for Xklp2) protein family Neighboring gene tRNA-Lys Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Polycomb proteins RING1A/B promote H2A monoubiquitination to regulate female gametophyte development in Arabidopsis. Lv Y, et al. J Exp Bot, 2024 Aug 28. PMID 38717070
    2. The Arabidopsis PRC1-like ring-finger proteins are necessary for repression of embryonic traits during vegetative growth. Chen D, et al. Cell Res, 2010 Dec. PMID 21060339
    3. The Arabidopsis Nodulin Homeobox Factor AtNDX Interacts with AtRING1A/B and Negatively Regulates Abscisic Acid Signaling. Zhu Y, et al. Plant Cell, 2020 Mar. PMID 31919300, Free PMC Article
    4. Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch. Peng L, et al. J Mol Biol, 2018 Oct 19. PMID 30176245
    5. The putative PRC1 RING-finger protein AtRING1A regulates flowering through repressing MADS AFFECTING FLOWERING genes in Arabidopsis. Shen L, et al. Development, 2014 Mar. PMID 24553292

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polycomb proteins RING1A/B promote H2A monoubiquitination to regulate female gametophyte development in Arabidopsis.
      Title: Polycomb proteins RING1A/B promote H2A monoubiquitination to regulate female gametophyte development in Arabidopsis.
    2. The Arabidopsis Nodulin Homeobox Factor AtNDX Interacts with AtRING1A/B and Negatively Regulates Abscisic Acid Signaling.
      Title: The Arabidopsis Nodulin Homeobox Factor AtNDX Interacts with AtRING1A/B and Negatively Regulates Abscisic Acid Signaling.
    3. Two PAL-binding sites were found on AtRING1a. Each of them can bind AL proteins but with different affinities and distinct structural bases.
      Title: Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch.
    4. RING1A suppresses the expression of MAF4 and MAF5 through affecting H3K27me3 levels at these loci to regulate the floral transition
      Title: The putative PRC1 RING-finger protein AtRING1A regulates flowering through repressing MADS AFFECTING FLOWERING genes in Arabidopsis.
    5. AtRING1a is elevated in the Atbmi1a Atbmi1b mutant, suggesting a self-regulatory feedback mechanism.
      Title: The Arabidopsis PRC1-like ring-finger proteins are necessary for repression of embryonic traits during vegetative growth.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001161288.1
    NM_001344539.1
    NM_123795.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of floral meristem identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of inflorescence meristem identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of shoot apical meristem identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression, epigenetic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of PRC1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RING 1A
    NP_001154760.1
    • RING 1A (RING1A); FUNCTIONS IN: zinc ion binding; INVOLVED IN: negative regulation of gene expression, epigenetic; LOCATED IN: nucleus, PRC1 complex; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; BEST Arabidopsis thaliana protein match is: RING 1B (TAIR:AT1G03770.1); Has 9014 Blast hits to 7495 proteins in 568 species: Archae - 41; Bacteria - 677; Metazoa - 3346; Fungi - 1171; Plants - 610; Viruses - 87; Other Eukaryotes - 3082 (source: NCBI BLink).
    NP_199241.2
    • RING 1A (RING1A); FUNCTIONS IN: zinc ion binding; INVOLVED IN: negative regulation of gene expression, epigenetic; LOCATED IN: nucleus, PRC1 complex; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING 1B (TAIR:AT1G03770.1); Has 87950 Blast hits to 40013 proteins in 1982 species: Archae - 331; Bacteria - 6780; Metazoa - 33639; Fungi - 11315; Plants - 4932; Viruses - 1435; Other Eukaryotes - 29518 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17835810..17839303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123795.5 → NP_199241.2  RING 1A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199241.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FKW0
      UniProtKB/TrEMBL
      A0A178UDU8, A0A654G8D7
      Conserved Domains (2) summary
      COG5222
      Location:134 → 216
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd16531
      Location:136 → 176
      RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins

    2. NM_001161288.1 → NP_001154760.1  RING 1A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154760.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G8D7, F4K8U4

    3. NM_001344539.1 → NP_001331587.1  RING 1A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEC3, A0A7G2FK32
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FKW0.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.