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    THE1 protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835526, updated on 18-Sep-2024

    Summary

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    Official Symbol
    THE1
    Official Full Name
    protein kinase family protein
    Primary source
    TAIR:AT5G54380
    Locus tag
    AT5G54380
    See related
    Araport:AT5G54380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GA469.3; GA469_3; THESEUS1
    Summary
    Encodes THESEUS1 (THE1), a receptor kinase regulated by Brassinosteroids and required for cell elongation during vegetative growth.
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    Genomic context

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    See THE1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (22077040..22080341, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Late embryogenesis abundant (LEA) protein-like protein Neighboring gene tRNA-Phe Neighboring gene ncRNA Neighboring gene HAL2-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. T-DNA alleles of the receptor kinase THESEUS1 with opposing effects on cell wall integrity signaling. Merz D, et al. J Exp Bot, 2017 Jul 20. PMID 28981771, Free PMC Article
    2. A receptor-like kinase mediates the response of Arabidopsis cells to the inhibition of cellulose synthesis. Hématy K, et al. Curr Biol, 2007 Jun 5. PMID 17540573
    3. Receptor Kinase THESEUS1 Is a Rapid Alkalinization Factor 34 Receptor in Arabidopsis. Gonneau M, et al. Curr Biol, 2018 Aug 6. PMID 30057301
    4. THESEUS1 positively modulates plant defense responses against Botrytis cinerea through GUANINE EXCHANGE FACTOR4 signaling. Qu S, et al. J Integr Plant Biol, 2017 Nov. PMID 28646554
    5. The Arabidopsis leucine-rich repeat receptor kinase MIK2/LRR-KISS connects cell wall integrity sensing, root growth and response to abiotic and biotic stresses. Van der Does D, et al. PLoS Genet, 2017 Jun. PMID 28604776, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis Root Tip (Phospho)Proteomes at Growth-Promoting versus Growth-Repressing Conditions Reveal Novel Root Growth Regulators.
      Title: The Arabidopsis Root Tip (Phospho)Proteomes at Growth-Promoting versus Growth-Repressing Conditions Reveal Novel Root Growth Regulators.
    2. Together, the results show that RALF34 and THE1 are part of a signaling network that integrates information on the integrity of the cell wall with the coordination of normal morphogenesis.
      Title: Receptor Kinase THESEUS1 Is a Rapid Alkalinization Factor 34 Receptor in Arabidopsis.
    3. THE1 signaling upon cell wall damage has a negative impact on cell expansion.THE1 alleles have opposing effects on plant growth, ectopic lignification, and gene expression.
      Title: T-DNA alleles of the receptor kinase THESEUS1 with opposing effects on cell wall integrity signaling.
    4. both the increased root skewing and salt stress sensitivity phenotypes observed in the mik2 mutant are dependent on THE1. Finally, we found that MIK2 is required for resistance to the fungal root pathogen Fusarium oxysporum
      Title: The Arabidopsis leucine-rich repeat receptor kinase MIK2/LRR-KISS connects cell wall integrity sensing, root growth and response to abiotic and biotic stresses.
    5. These findings position the THESEUS 1/FERONIA family RLKs as surface regulators and potential cell wall sensors capable of broadly and profoundly impacting cellular pathways in response to diverse signals.
      Title: THESEUS 1, FERONIA and relatives: a family of cell wall-sensing receptor kinases?
    6. 3 related receptor-like kinases, HERCULES1, THESEUS1, and FERONIA, transcriptionally induced by brassinosteroids are charcterized in this study.
      Title: Three related receptor-like kinases are required for optimal cell elongation in Arabidopsis thaliana.
    7. THE1 mediates the response of growing plant cells to the perturbation of cellulose synthesis and may act as a cell-wall-integrity sensor.
      Title: A receptor-like kinase mediates the response of Arabidopsis cells to the inhibition of cellulose synthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124818.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brassinosteroid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of unidimensional cell growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to brassinosteroid IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    protein kinase family protein
    NP_200249.1
    • THESEUS1 (THE1); FUNCTIONS IN: protein kinase activity, kinase activity; INVOLVED IN: in 6 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Malectin/receptor-like protein kinase (InterPro:IPR021720), Protein kinase, catalytic domain (InterPro:IPR000719), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: hercules receptor kinase 1 (TAIR:AT3G46290.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22077040..22080341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124818.4 → NP_200249.1  protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200249.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LK35
      UniProtKB/TrEMBL
      A0A178U7Z8, A0A5S9YE69
      Conserved Domains (3) summary
      cd14066
      Location:516 → 781
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam11721
      Location:210 → 382
      Malectin; Di-glucose binding within endoplasmic reticulum
      pfam12819
      Location:34 → 384
      Malectin_like; Carbohydrate-binding protein of the ER
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LK35.1

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