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    D6PK D6 protein kinase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835689, updated on 18-Sep-2024

    Summary

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    Official Symbol
    D6PK
    Official Full Name
    D6 protein kinase
    Primary source
    TAIR:AT5G55910
    Locus tag
    AT5G55910
    See related
    Araport:AT5G55910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    D6 protein kinase; MYN21.2; MYN21_2
    Summary
    D6PK is a protein kinase involved that plays a role in polar auxin transport. Most likely acts redundantly with the related proteins: D6PKL1,D6PKL2,and D6PKL3. PIN1 is a target of D6PK phosphorylation.
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    Genomic context

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    See D6PK in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (22639813..22642414, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sucrase/ferredoxin-like family protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene oligopeptide transporter 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phospholipid composition and a polybasic motif determine D6 PROTEIN KINASE polar association with the plasma membrane and tropic responses. Barbosa IC, et al. Development, 2016 Dec 15. PMID 27836964
    2. Auxin efflux by PIN-FORMED proteins is activated by two different protein kinases, D6 PROTEIN KINASE and PINOID. Zourelidou M, et al. Elife, 2014 Jun 19. PMID 24948515, Free PMC Article
    3. Dynamic PIN-FORMED auxin efflux carrier phosphorylation at the plasma membrane controls auxin efflux-dependent growth. Weller B, et al. Proc Natl Acad Sci U S A, 2017 Jan 31. PMID 28096328, Free PMC Article
    4. A protein kinase target of a PDK1 signalling pathway is involved in root hair growth in Arabidopsis. Anthony RG, et al. EMBO J, 2004 Feb 11. PMID 14749726, Free PMC Article
    5. AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells. Glanc M, et al. Curr Biol, 2021 May 10. PMID 33705718, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PID, but not D6PK, can also induce PIN1 polarity shifts, seemingly through phosphorylation at S1-S3. Phosphosite preferences are not sufficient to explain these differential effects of D6PK and PID on PIN1 polarity.
      Title: Dynamic PIN-FORMED auxin efflux carrier phosphorylation at the plasma membrane controls auxin efflux-dependent growth.
    2. the association of D6PK with the basal plasma membrane and PIN-FORMED auxin efflux carriers is dependent on the phospholipid composition of the plasma membrane as well as on the phosphatidylinositol phosphate 5-kinases PIP5K1 and PIP5K2 in epidermis cells of the primary root. D6PK directly binds polyacidic phospholipids through a polybasic lysine-rich motif in the middle domain of the kinase.
      Title: Phospholipid composition and a polybasic motif determine D6 PROTEIN KINASE polar association with the plasma membrane and tropic responses.
    3. PIN-mediated auxin transport is directly activated by D6 PROTEIN KINASE (D6PK) and PINOID (PID)/WAG kinases of the Arabidopsis AGCVIII kinase family
      Title: Auxin efflux by PIN-FORMED proteins is activated by two different protein kinases, D6 PROTEIN KINASE and PINOID.
    4. Data show that phototropic hypocotyl bending is strongly dependent on the activity of D6PKs and the PIN-FORMED (PIN) auxin efflux facilitators PIN3, PIN4, and PIN7.
      Title: D6PK AGCVIII kinases are required for auxin transport and phototropic hypocotyl bending in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001345171.1
    NM_124973.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-5-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within basipetal auxin transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phototropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D6 protein kinase
    NP_200402.1
    • D6 protein kinase (D6PK); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: D6 protein kinase like 1 (TAIR:AT4G26610.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22639813..22642414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124973.5 → NP_200402.1  D6 protein kinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200402.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39031, Q9FG74
      UniProtKB/TrEMBL
      A0A178UEL3, A0A5S9YF30
      Conserved Domains (1) summary
      cd05574
      Location:108 → 470
      STKc_phototropin_like; Catalytic domain of Phototropin-like Serine/Threonine Kinases

    2. NM_001345171.1 → NP_001332267.1  D6 protein kinase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39031, Q9FG74
      UniProtKB/TrEMBL
      A0A178UEL3, A0A5S9YF30
      Conserved Domains (1) summary
      cd05574
      Location:108 → 470
      STKc_phototropin_like; Catalytic domain of Phototropin-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FG74.1

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