Zbtb18 zinc finger and BTB domain containing 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb18provided by MGI
Official Full Name: zinc finger and BTB domain containing 18provided by MGI
Primary source: MGI:MGI:1353609
See related: Ensembl:ENSMUSG00000063659 AllianceGenome:MGI:1353609
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RP58; Zfp238; Znf238.; zfp-238
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and skeletal muscle tissue development. Acts upstream of or within several processes, including in utero embryonic development; nervous system development; and regulation of cell division. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; nervous system; sensory organ; and skeleton. Used to study autosomal dominant intellectual developmental disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 22. Orthologous to human ZBTB18 (zinc finger and BTB domain containing 18). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cerebellum adult (RPKM 43.4), CNS E18 (RPKM 26.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H4; 1 82.72 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (177269892..177278330)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (177442351..177450764)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor).
Title: Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor).
The mouse model of intellectual disability by ZBTB18/RP58 haploinsufficiency shows cognitive dysfunction with synaptic impairment.
Title: The mouse model of intellectual disability by ZBTB18/RP58 haploinsufficiency shows cognitive dysfunction with synaptic impairment.
ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis.
Title: ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis.
RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons.
Title: RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons.
Findings demonstrate functional interplay between a transcriptional regulator and p27(kip1) to mediate neuroprogenitor cell cycle exit, as well as to promote radial migration through a molecular mechanism consistent with suppression of RhoA signaling.
Title: Rp58 and p27(kip1) coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex.
Disruption of RP58 expression alters the differentiation of immature neurons and impairs their migration and positioning within the mouse cerebral cortex.
Title: The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development.
RP58 represses Ngn2 transcription to regulate the Ngn2-Rnd2 pathway; Ngn2 knockdown rescued migration defects of the RP58(-/-) neurons.
Title: RP58 regulates the multipolar-bipolar transition of newborn neurons in the developing cerebral cortex.
Rp58 is essential for the growth and organization of the cerebellum and regulates the development of both GABAergic and glutamatergic neurons.
Title: Rp58 is essential for the growth and patterning of the cerebellum and for glutamatergic and GABAergic neuron development.
RP58 may act to favor neuronal differentiation and brain growth by coherently repressing multiple proneurogenic genes in a timely manner.
Title: RP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion.
This study showed that Cre recombinase expression under the control of the RP58 gene promoter is a feasible tool for conditional gene switching in post-mitotic multipolar migrating young neurons in the developing cerebral cortex.
Title: The 5'-flanking region of the RP58 coding sequence shows prominent promoter activity in multipolar cells in the subventricular zone during corticogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S1950E (e-PCR)
- UniSTS:151302

Zfp238 (e-PCR), detects polymorphism
- UniSTS:528217

Zfp238 (e-PCR), detects polymorphism
- UniSTS:507337

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebellum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 18

Names: 58 kDa repressor protein; transcriptional repressor RP58; zinc finger protein 238

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012330.2 → NP_001012330.1 zinc finger and BTB domain-containing protein 18 isoform 1

See identical proteins and their annotated locations for NP_001012330.1

Status: VALIDATED

Source sequence(s)

AC120370

Consensus CDS

CCDS35800.1

UniProtKB/TrEMBL

H7BX69

Related

ENSMUSP00000091831.4, ENSMUST00000094276.5

Conserved Domains (4) summary

COG5048
Location:303 → 490

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:421 → 441

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:10 → 156

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:434 → 456

zf-H2C2_2; Zinc-finger double domain
NM_001355098.2 → NP_001342027.1 zinc finger and BTB domain-containing protein 18 isoform 1

Status: VALIDATED

Source sequence(s)

AC120370

Consensus CDS

CCDS35800.1

UniProtKB/TrEMBL

H7BX69

Conserved Domains (4) summary

COG5048
Location:303 → 490

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:421 → 441

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:10 → 156

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:434 → 456

zf-H2C2_2; Zinc-finger double domain
NM_001355099.2 → NP_001342028.1 zinc finger and BTB domain-containing protein 18 isoform 2

Status: VALIDATED

Source sequence(s)

AC120370

Consensus CDS

CCDS15553.1

UniProtKB/Swiss-Prot

Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6

Conserved Domains (4) summary

COG5048
Location:294 → 481

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:412 → 432

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:1 → 147

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:425 → 447

zf-H2C2_2; Zinc-finger double domain
NM_001355100.2 → NP_001342029.1 zinc finger and BTB domain-containing protein 18 isoform 2

Status: VALIDATED

Source sequence(s)

AC120370

Consensus CDS

CCDS15553.1

UniProtKB/Swiss-Prot

Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6

Conserved Domains (4) summary

COG5048
Location:294 → 481

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:412 → 432

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:1 → 147

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:425 → 447

zf-H2C2_2; Zinc-finger double domain
NM_001355101.2 → NP_001342030.1 zinc finger and BTB domain-containing protein 18 isoform 2

Status: VALIDATED

Source sequence(s)

AC120370

Consensus CDS

CCDS15553.1

UniProtKB/Swiss-Prot

Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6

Conserved Domains (4) summary

COG5048
Location:294 → 481

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:412 → 432

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:1 → 147

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:425 → 447

zf-H2C2_2; Zinc-finger double domain
NM_001355102.2 → NP_001342031.1 zinc finger and BTB domain-containing protein 18 isoform 2

Status: VALIDATED

Source sequence(s)

AC120370

Consensus CDS

CCDS15553.1

UniProtKB/Swiss-Prot

Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6

Related

ENSMUSP00000141724.2, ENSMUST00000195612.2

Conserved Domains (4) summary

COG5048
Location:294 → 481

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:412 → 432

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:1 → 147

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:425 → 447

zf-H2C2_2; Zinc-finger double domain
NM_001355103.2 → NP_001342032.1 zinc finger and BTB domain-containing protein 18 isoform 3

Status: VALIDATED

Source sequence(s)

AC120370

Consensus CDS

CCDS87929.1

UniProtKB/TrEMBL

A0A0A6YWR6, A0A0A6YY33

Related

ENSMUSP00000141663.2, ENSMUST00000193480.2

Conserved Domains (1) summary

cd18324
Location:10 → 156

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)
NM_001421570.1 → NP_001408499.1 zinc finger and BTB domain-containing protein 18 isoform 1

Status: VALIDATED

Source sequence(s)

AC120370

UniProtKB/TrEMBL

H7BX69
NM_001421571.1 → NP_001408500.1 zinc finger and BTB domain-containing protein 18 isoform 2

Status: VALIDATED

Source sequence(s)

AC120370

UniProtKB/Swiss-Prot

Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6
NM_001421572.1 → NP_001408501.1 zinc finger and BTB domain-containing protein 18 isoform 2

Status: VALIDATED

Source sequence(s)

AC120370

UniProtKB/Swiss-Prot

Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6
NM_001421573.1 → NP_001408502.1 zinc finger and BTB domain-containing protein 18 isoform 2

Status: VALIDATED

Source sequence(s)

AC120370

UniProtKB/Swiss-Prot

Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6
NM_001421574.1 → NP_001408503.1 zinc finger and BTB domain-containing protein 18 isoform 3

Status: VALIDATED

Source sequence(s)

AC120370

UniProtKB/TrEMBL

A0A0A6YWR6, A0A0A6YY33
NM_013915.4 → NP_038943.3 zinc finger and BTB domain-containing protein 18 isoform 2

See identical proteins and their annotated locations for NP_038943.3

Status: VALIDATED

Source sequence(s)

AC120370

Consensus CDS

CCDS15553.1

UniProtKB/Swiss-Prot

Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6

Related

ENSMUSP00000076463.7, ENSMUST00000077225.8

Conserved Domains (4) summary

COG5048
Location:294 → 481

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:412 → 432

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:1 → 147

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:425 → 447

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

177269892..177278330

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165663.1 → XP_036021556.1 zinc finger and BTB domain-containing protein 18 isoform X1

UniProtKB/TrEMBL

H7BX69

Conserved Domains (4) summary

COG5048
Location:303 → 490

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:421 → 441

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:10 → 156

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:434 → 456

zf-H2C2_2; Zinc-finger double domain
XM_036165661.1 → XP_036021554.1 zinc finger and BTB domain-containing protein 18 isoform X1

UniProtKB/TrEMBL

H7BX69

Conserved Domains (4) summary

COG5048
Location:303 → 490

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:421 → 441

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:10 → 156

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:434 → 456

zf-H2C2_2; Zinc-finger double domain
XM_036165664.1 → XP_036021557.1 zinc finger and BTB domain-containing protein 18 isoform X1

UniProtKB/TrEMBL

H7BX69

Conserved Domains (4) summary

COG5048
Location:303 → 490

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:421 → 441

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:10 → 156

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:434 → 456

zf-H2C2_2; Zinc-finger double domain
XM_036165662.1 → XP_036021555.1 zinc finger and BTB domain-containing protein 18 isoform X1

UniProtKB/TrEMBL

H7BX69

Conserved Domains (4) summary

COG5048
Location:303 → 490

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:421 → 441

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:10 → 156

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:434 → 456

zf-H2C2_2; Zinc-finger double domain
XM_006496889.5 → XP_006496952.1 zinc finger and BTB domain-containing protein 18 isoform X1

See identical proteins and their annotated locations for XP_006496952.1

UniProtKB/TrEMBL

H7BX69

Conserved Domains (4) summary

COG5048
Location:303 → 490

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:421 → 441

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:10 → 156

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:434 → 456

zf-H2C2_2; Zinc-finger double domain
XM_030254847.2 → XP_030110707.1 zinc finger and BTB domain-containing protein 18 isoform X2

UniProtKB/Swiss-Prot

Q3UHU9, Q7TMA6, Q80YQ4, Q9WUK6

Conserved Domains (4) summary

COG5048
Location:294 → 481

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:412 → 432

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18324
Location:1 → 147

BTB_POZ_ZBTB18_RP58; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18)

pfam13465
Location:425 → 447

zf-H2C2_2; Zinc-finger double domain