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    Chil5 chitinase-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 229687, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chil5provided by MGI
    Official Full Name
    chitinase-like 5provided by MGI
    Primary source
    MGI:MGI:2676649
    See related
    Ensembl:ENSMUSG00000043873 AllianceGenome:MGI:2676649
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bclp; Bclp1; Bclp2; Chi3l7
    Summary
    Predicted to enable chitin binding activity; chitinase activity; and kinase binding activity. Predicted to be involved in chitin catabolic process; positive regulation of chemokine production; and production of molecular mediator involved in inflammatory response. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in lung. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Chil5 in Genome Data Viewer
    Location:
    3 F2.2; 3 46.47 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105924235..105940262, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (106016919..106032949, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene oviductal glycoprotein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6099 Neighboring gene ciliary microtubule associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_08642 Neighboring gene predicted gene 42722 Neighboring gene STARR-seq mESC enhancer starr_08643 Neighboring gene predicted gene 4540 Neighboring gene uncharacterized protein C9orf85 homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Van Dyken SJ, et al. Cell, 2017 Apr 20. PMID 28431248, Free PMC Article
    2. New paralogues and revised time line in the expansion of the vertebrate GH18 family. Hussain M, et al. J Mol Evol, 2013 Apr. PMID 23558346
    3. Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Desai J, et al. Hum Mol Genet, 2006 Apr 15. PMID 16537572
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156874

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in production of molecular mediator involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    chitinase like
    Names
    chitinase 3-like 7
    chitinase like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080816.2 → NP_001074285.1  chitinase like precursor

      Status: VALIDATED

      Source sequence(s)
      AB081756, AC025786, AI851591, BC116403
      Consensus CDS
      CCDS38584.1
      UniProtKB/TrEMBL
      A0A0G2JDS2
      Related
      ENSMUSP00000142477.2, ENSMUST00000200146.2
      Conserved Domains (2) summary
      cd02872
      Location:24 → 387
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:26 → 365
      Glyco_18; Glyco_18 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      105924235..105940262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502521.5 → XP_006502584.1  chitinase like isoform X1

      See identical proteins and their annotated locations for XP_006502584.1

      Conserved Domains (1) summary
      cl10447
      Location:24 → 304
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

    2. XM_006502522.5 → XP_006502585.1  chitinase like isoform X2

      See identical proteins and their annotated locations for XP_006502585.1

      Conserved Domains (1) summary
      cl10447
      Location:24 → 271
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

    3. XM_006502523.4 → XP_006502586.1  chitinase like isoform X3

      See identical proteins and their annotated locations for XP_006502586.1

      UniProtKB/TrEMBL
      A0JP54, F7AQE8
      Related
      ENSMUSP00000065043.5, ENSMUST00000066537.10
      Conserved Domains (1) summary
      cl10447
      Location:1 → 196
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

    4. XM_006502524.5 → XP_006502587.1  chitinase like isoform X4

      See identical proteins and their annotated locations for XP_006502587.1

      UniProtKB/TrEMBL
      Q08EE2
      Conserved Domains (1) summary
      cl10447
      Location:11 → 194
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_170594.1: Suppressed sequence

      Description
      NM_170594.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

    2. NM_201246.1: Suppressed sequence

      Description
      NM_201246.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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