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    Lax1 lymphocyte transmembrane adaptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 240754, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lax1provided by MGI
    Official Full Name
    lymphocyte transmembrane adaptor 1provided by MGI
    Primary source
    MGI:MGI:2443362
    See related
    Ensembl:ENSMUSG00000051998 AllianceGenome:MGI:2443362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A530029E09; E430019B13Rik
    Summary
    Predicted to enable SH2 domain binding activity and protein kinase binding activity. Acts upstream of or within antigen receptor-mediated signaling pathway and lymphocyte activation. Predicted to be located in Golgi apparatus; cytosol; and membrane. Predicted to be active in plasma membrane. Orthologous to human LAX1 (lymphocyte transmembrane adaptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 14.6), thymus adult (RPKM 5.7) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lax1 in Genome Data Viewer
    Location:
    1 E4; 1 57.95 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133606767..133620760, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133679017..133693022, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02294 Neighboring gene small nuclear ribonucleoprotein E Neighboring gene predicted gene, 53475 Neighboring gene zinc finger CCCH type containing 11A Neighboring gene zinc finger, BED type containing 6 Neighboring gene STARR-seq mESC enhancer starr_02296 Neighboring gene STARR-seq mESC enhancer starr_02297 Neighboring gene STARR-seq mESC enhancer starr_02298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135586656-135586812 Neighboring gene STARR-seq mESC enhancer starr_02299 Neighboring gene ATPase, Ca++ transporting, plasma membrane 4 Neighboring gene STARR-seq mESC enhancer starr_02301 Neighboring gene microRNA 6903 Neighboring gene STARR-seq mESC enhancer starr_02302 Neighboring gene predicted gene, 53476

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX. Zhu M, et al. J Biol Chem, 2006 Jul 7. PMID 16672218
    2. Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX. Arndt B, et al. J Leukoc Biol, 2013 Mar. PMID 23307938
    3. Negative regulation of lymphocyte activation by the adaptor protein LAX. Zhu M, et al. J Immunol, 2005 May 1. PMID 15843560
    4. Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. Zhu M, et al. J Biol Chem, 2002 Nov 29. PMID 12359715
    5. Molecular genetic analysis of two loci (Ity2 and Ity3) involved in the host response to infection with Salmonella typhimurium using congenic mice and expression profiling. Sancho-Shimizu V, et al. Genetics, 2007 Oct. PMID 17660555, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SIT and LAX are important negative regulators of immune responses that functionally cooperate.
      Title: Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX.
    2. Upon T or B cell activation, the LAX protein is up-regulated dramatically. This in vivo study of LAX-deficient mice demonstrates that LAX functions as a negative regulator in lymphocyte signaling.
      Title: Negative regulation of lymphocyte activation by the adaptor protein LAX.
    3. LAX negatively regulates mast cell function
      Title: Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH2 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in B cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antigen receptor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within antigen receptor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lymphocyte activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lymphocyte activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lymphocyte transmembrane adapter 1
    Names
    linker for activation of X cells
    membrane-associated adapter protein LAX

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159649.1 → NP_001153121.1  lymphocyte transmembrane adapter 1

      See identical proteins and their annotated locations for NP_001153121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124338, AY090785
      Consensus CDS
      CCDS35711.1
      UniProtKB/Swiss-Prot
      Q8BHB3, Q8BS18, Q8CGV1
      Related
      ENSMUSP00000131126.2, ENSMUST00000169295.8
      Conserved Domains (1) summary
      pfam15681
      Location:28 → 356
      LAX; Lymphocyte activation family X

    2. NM_172842.3 → NP_766430.3  lymphocyte transmembrane adapter 1

      See identical proteins and their annotated locations for NP_766430.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124338, AY090785
      Consensus CDS
      CCDS35711.1
      UniProtKB/Swiss-Prot
      Q8BHB3, Q8BS18, Q8CGV1
      Conserved Domains (1) summary
      pfam15681
      Location:28 → 356
      LAX; Lymphocyte activation family X

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      133606767..133620760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529557.5 → XP_006529620.1  lymphocyte transmembrane adapter 1 isoform X1

      See identical proteins and their annotated locations for XP_006529620.1

      UniProtKB/Swiss-Prot
      Q8BHB3, Q8BS18, Q8CGV1
      Conserved Domains (1) summary
      pfam15681
      Location:28 → 356
      LAX; Lymphocyte activation family X
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHB3.2 GenPept UniProtKB/Swiss-Prot:Q8BHB3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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