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    Rnf170 ring finger protein 170 [ Mus musculus (house mouse) ]

    Gene ID: 77733, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnf170provided by MGI
    Official Full Name
    ring finger protein 170provided by MGI
    Primary source
    MGI:MGI:1924983
    See related
    Ensembl:ENSMUSG00000013878 AllianceGenome:MGI:1924983
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6720407G21Rik
    Summary
    Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including adult walking behavior; protein K48-linked ubiquitination; and toll-like receptor 3 signaling pathway. Predicted to be active in endoplasmic reticulum membrane. Used to study hereditary ataxia. Human ortholog(s) of this gene implicated in autosomal dominant sensory ataxia 1 and hereditary spastic paraplegia 85. Orthologous to human RNF170 (ring finger protein 170). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf170 in Genome Data Viewer
    Location:
    8 A2; 8 14.38 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26609396..26633903)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (26119368..26143875)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene hook microtubule tethering protein 3 Neighboring gene RIKEN cDNA 1700047A11 gene Neighboring gene STARR-seq mESC enhancer starr_20998 Neighboring gene calcium binding protein 39 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E879 Neighboring gene STARR-seq mESC enhancer starr_20999 Neighboring gene THAP domain containing, apoptosis associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_21000 Neighboring gene STARR-seq mESC enhancer starr_21002 Neighboring gene STARR-seq mESC enhancer starr_21003 Neighboring gene predicted gene, 31727

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia. Kim Y, et al. Hum Mol Genet, 2015 Dec 20. PMID 26433933
    2. E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells. Song X, et al. Cell Mol Immunol, 2020 Aug. PMID 31076723, Free PMC Article
    3. The erlin2 T65I mutation inhibits erlin1/2 complex-mediated inositol 1,4,5-trisphosphate receptor ubiquitination and phosphatidylinositol 3-phosphate binding. Wright FA, et al. J Biol Chem, 2018 Oct 5. PMID 30135210, Free PMC Article
    4. RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation. Lu JP, et al. J Biol Chem, 2011 Jul 8. PMID 21610068, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells.
      Title: E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118197

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of toll-like receptor 3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proprioception ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein K48-linked ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within toll-like receptor 3 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF170
    Names
    RING-type E3 ubiquitin transferase RNF170
    NP_001344221.1
    NP_001344222.2
    NP_001344223.2
    NP_001344224.2
    NP_084241.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357292.1 → NP_001344221.1  E3 ubiquitin-protein ligase RNF170 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC093366, AI851211, AK042063, AK162554, BC114210
      Consensus CDS
      CCDS90380.1
      UniProtKB/Swiss-Prot
      A6H618, Q3U796, Q78QX6, Q8C8S1, Q8C9I0, Q8CBG9, Q8K0H6
      Related
      ENSMUSP00000118689.2, ENSMUST00000153528.8
      Conserved Domains (2) summary
      pfam06803
      Location:185 → 218
      DUF1232; Protein of unknown function (DUF1232)
      cd16553
      Location:68 → 111
      RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins

    2. NM_001357293.2 → NP_001344222.2  E3 ubiquitin-protein ligase RNF170 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC093366
      Consensus CDS
      CCDS22207.1
      UniProtKB/Swiss-Prot
      A6H618, Q3U796, Q78QX6, Q8C8S1, Q8C9I0, Q8CBG9, Q8K0H6
      Conserved Domains (2) summary
      pfam06803
      Location:203 → 236
      DUF1232; Protein of unknown function (DUF1232)
      cd16553
      Location:86 → 129
      RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins

    3. NM_001357294.2 → NP_001344223.2  E3 ubiquitin-protein ligase RNF170 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC093366
      Consensus CDS
      CCDS22207.1
      UniProtKB/Swiss-Prot
      A6H618, Q3U796, Q78QX6, Q8C8S1, Q8C9I0, Q8CBG9, Q8K0H6
      Conserved Domains (2) summary
      pfam06803
      Location:203 → 236
      DUF1232; Protein of unknown function (DUF1232)
      cd16553
      Location:86 → 129
      RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins

    4. NM_001357295.2 → NP_001344224.2  E3 ubiquitin-protein ligase RNF170 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC093366
      Consensus CDS
      CCDS22207.1
      UniProtKB/Swiss-Prot
      A6H618, Q3U796, Q78QX6, Q8C8S1, Q8C9I0, Q8CBG9, Q8K0H6
      Conserved Domains (2) summary
      pfam06803
      Location:203 → 236
      DUF1232; Protein of unknown function (DUF1232)
      cd16553
      Location:86 → 129
      RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins

    5. NM_029965.4 → NP_084241.2  E3 ubiquitin-protein ligase RNF170 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC093366
      Consensus CDS
      CCDS22207.1
      UniProtKB/Swiss-Prot
      A6H618, Q3U796, Q78QX6, Q8C8S1, Q8C9I0, Q8CBG9, Q8K0H6
      Related
      ENSMUSP00000014022.9, ENSMUST00000014022.15
      Conserved Domains (2) summary
      pfam06803
      Location:203 → 236
      DUF1232; Protein of unknown function (DUF1232)
      cd16553
      Location:86 → 129
      RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins

    RNA

    1. NR_151666.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI851211, AK153658, AK162554, BC114210

    2. NR_151667.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093366

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      26609396..26633903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CBG9.1 GenPept UniProtKB/Swiss-Prot:Q8CBG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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