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    Spryd3 SPRY domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 223918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spryd3provided by MGI
    Official Full Name
    SPRY domain containing 3provided by MGI
    Primary source
    MGI:MGI:2446175
    See related
    Ensembl:ENSMUSG00000036966 AllianceGenome:MGI:2446175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SPRYD3 (SPRY domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 39.1), cortex adult (RPKM 35.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spryd3 in Genome Data Viewer
    Location:
    15 F2; 15 57.3 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102024961..102044678, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102116526..102136218, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39815 Neighboring gene eukaryotic translation initiation factor 4B Neighboring gene predicted gene, 53915 Neighboring gene tensin 2 Neighboring gene STARR-positive B cell enhancer ABC_E482 Neighboring gene insulin-like growth factor binding protein 6 Neighboring gene sterol O-acyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    SPRY domain-containing protein 3
    NP_001028449.2
    XP_006520949.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033277.3 → NP_001028449.2  SPRY domain-containing protein 3

      See identical proteins and their annotated locations for NP_001028449.2

      Status: VALIDATED

      Source sequence(s)
      AI427285, BG293312, BQ031507, BU057890, BY739425, CA323202, CX201967
      Consensus CDS
      CCDS49738.1
      UniProtKB/TrEMBL
      E9Q9B3, Q3UIZ3
      Related
      ENSMUSP00000121493.2, ENSMUST00000154032.2
      Conserved Domains (1) summary
      cd12908
      Location:220 → 438
      SPRYD3; SPRY domain-containing protein 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      102024961..102044678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520886.4 → XP_006520949.1  SPRY domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      Q3UIZ3
      Conserved Domains (1) summary
      cd12908
      Location:220 → 438
      SPRYD3; SPRY domain-containing protein 3
    Nucleotide Protein Strain
    Heading Accession and Version

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