Pml promyelocytic leukemia [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pmlprovided by MGI
Official Full Name: promyelocytic leukemiaprovided by MGI
Primary source: MGI:MGI:104662
See related: Ensembl:ENSMUSG00000036986 AllianceGenome:MGI:104662
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trim19; 1200009E24Rik
Summary: Enables SMAD binding activity. Involved in several processes, including defense response to symbiont; regulation of gene expression; and signal transduction by p53 class mediator. Acts upstream of or within several processes, including apoptotic signaling pathway; cell surface receptor protein serine/threonine kinase signaling pathway; and cellular response to cytokine stimulus. Located in PML body; cytosol; and nuclear matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin cancer. Orthologous to human PML (PML nuclear body scaffold). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 20.1), thymus adult (RPKM 9.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 31.63 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (58125359..58157077, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (58217179..58249796, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.
Title: PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.
JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML.
Title: JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML.
we uncovered a novel reciprocal loop of TGF-beta1/PML SUMOylation/Pin1 leading to myocardial fibrosis.
Title: TGF-β1-PML SUMOylation-peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) form a positive feedback loop to regulate cardiac fibrosis.
Loss of PML increases H3.3 deposition in subtelomeric, telomeric, pericentric and centromeric repeats in mouse embryonic fibroblasts, while other repeat classes are not affected.
Title: PML modulates H3.3 targeting to telomeric and centromeric repeats in mouse fibroblasts.
Pml Nuclear bodies (NB) are critical for DNA damage responses, and Pml NB disruption is a central contributor to Acute promyelocytic leukemia pathogenesis.
Title: Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice.
PML mediates the binding of PER2 to BMAL1 in the BMAL1/CLOCK heterodimer and is an important component in the organization of a functional clock complex in the nucleus.
Title: Interactive Organization of the Circadian Core Regulators PER2, BMAL1, CLOCK and PML.
Promyelocytic leukemia protein Pml -/- cells showed a higher proliferation rate, compared to Pml +/+ cells.
Title: A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.
PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX and DAXX.
Title: PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX.
Data indicate that promyelocytic leukemia protein knockout (Pml-/-) animals fail to properly activate oxidative stress-responsive p53 targets, whereas the NRF2 response is amplified and accelerated.
Title: PML is a ROS sensor activating p53 upon oxidative stress.
data support a model in which activation of myogenic differentiation results in PML NB loss, chromatin reorganization and DAXX relocalization, and provides a paradigm for understanding the consequence of PML loss in other cellular contexts, such as during cancer development and progression
Title: Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres.

Submit: New GeneRIF Correction See all GeneRIFs (98)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI661194 (e-PCR)
- UniSTS:165638

U33626 (e-PCR)
- UniSTS:125725

43.MMHAP20FRG10.seq (e-PCR)
- UniSTS:124490

Pml (e-PCR), detects polymorphism
- UniSTS:144225

NoName (e-PCR)
- UniSTS:236145

U33626 (e-PCR)
- UniSTS:163461

D1S3694 (e-PCR)
- UniSTS:474272

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables SMAD binding	IDA Inferred from Direct Assay more info	PubMed
enables SUMO binding	IEA Inferred from Electronic Annotation more info
enables SUMO binding	ISO Inferred from Sequence Orthology more info
enables SUMO transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO transferase activity	ISO Inferred from Sequence Orthology more info
enables cobalt ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within PML body organization	IDA Inferred from Direct Assay more info	PubMed
involved_in PML body organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to interleukin-4	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of protein location in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-1 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in oncogene-induced cell senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process involved in mammary gland involution	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-lysine acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein targeting	ISO Inferred from Sequence Orthology more info
involved_in protein targeting	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein-containing complex localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in suppression of viral release by host	IBA Inferred from Biological aspect of Ancestor more info
involved_in suppression of viral release by host	IDA Inferred from Direct Assay more info	PubMed
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in PML body	IBA Inferred from Biological aspect of Ancestor more info
located_in PML body	IDA Inferred from Direct Assay more info	PubMed
located_in PML body	IMP Inferred from Mutant Phenotype more info	PubMed
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein PML

Names: probable transcription factor PML

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311088.2 → NP_001298017.1 protein PML isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region that results in a frame-shift compared to variant 2. It encodes isoform 3, which is shorter than and has a distinct C-terminus compared to isoform 2.

Source sequence(s)

AC160976

Consensus CDS

CCDS81007.1

UniProtKB/TrEMBL

D3YXR5, D3Z3A6

Related

ENSMUSP00000122854.2, ENSMUST00000135310.8

Conserved Domains (2) summary

pfam12126
Location:244 → 580

DUF3583; Protein of unknown function (DUF3583)

pfam13923
Location:62 → 96

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
NM_008884.6 → NP_032910.3 protein PML isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame segment in the CDS, compared to variant 2. The resulting protein (isoform 1) is shorter than isoform 2.

Source sequence(s)

AC160976

Consensus CDS

CCDS23240.2

UniProtKB/Swiss-Prot

Q60953

UniProtKB/TrEMBL

Q8BSJ6

Related

ENSMUSP00000109771.3, ENSMUST00000114136.9

Conserved Domains (3) summary

pfam12126
Location:244 → 534

DUF3583; Protein of unknown function (DUF3583)

pfam13923
Location:62 → 96

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

cl10012
Location:573 → 722

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
NM_178087.5 → NP_835188.2 protein PML isoform 2

See identical proteins and their annotated locations for NP_835188.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longest transcript and it encodes the longest protein (isoform 2).

Source sequence(s)

AC160976

Consensus CDS

CCDS23239.1

UniProtKB/Swiss-Prot

Q60953, Q8CEJ1, Q8VCC4

UniProtKB/TrEMBL

A0A068EW80

Related

ENSMUSP00000082816.5, ENSMUST00000085673.11

Conserved Domains (4) summary

smart00336
Location:134 → 171

BBOX; B-Box-type zinc finger

pfam12126
Location:244 → 580

DUF3583; Protein of unknown function (DUF3583)

pfam13923
Location:62 → 96

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

cl10012
Location:619 → 768

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

58125359..58157077 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510861.3 → XP_006510924.1 protein PML isoform X2

Conserved Domains (6) summary

cd00162
Location:62 → 96

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam12126
Location:244 → 534

DUF3583; Protein of unknown function (DUF3583)

cd19804
Location:131 → 173

Bbox1_TRIM19_C-V; B-box-type 1 zinc finger found in promyelocytic leukemia protein (PML) and similar proteins

cl00034
Location:191 → 239

Bbox_SF; B-box-type zinc finger superfamily

cl10012
Location:573 → 722

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

cl17238
Location:60 → 96

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006510860.3 → XP_006510923.1 protein PML isoform X1

Conserved Domains (6) summary

cd00162
Location:62 → 96

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam12126
Location:244 → 580

DUF3583; Protein of unknown function (DUF3583)

cd19804
Location:131 → 173

Bbox1_TRIM19_C-V; B-box-type 1 zinc finger found in promyelocytic leukemia protein (PML) and similar proteins

cl00034
Location:191 → 239

Bbox_SF; B-box-type zinc finger superfamily

cl10012
Location:619 → 768

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

cl17238
Location:60 → 96

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_017313212.3 → XP_017168701.1 protein PML isoform X6

UniProtKB/TrEMBL

F7BTZ2

Conserved Domains (5) summary

cd00162
Location:62 → 96

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam12126
Location:244 → 534

DUF3583; Protein of unknown function (DUF3583)

cd19804
Location:131 → 173

Bbox1_TRIM19_C-V; B-box-type 1 zinc finger found in promyelocytic leukemia protein (PML) and similar proteins

cl00034
Location:191 → 239

Bbox_SF; B-box-type zinc finger superfamily

cl17238
Location:60 → 96

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_030244128.2 → XP_030099988.1 protein PML isoform X5

UniProtKB/TrEMBL

F7BTZ2

Related

ENSMUSP00000116787.2, ENSMUST00000126690.8

Conserved Domains (5) summary

cd00162
Location:62 → 96

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam12126
Location:244 → 534

DUF3583; Protein of unknown function (DUF3583)

cd19804
Location:131 → 173

Bbox1_TRIM19_C-V; B-box-type 1 zinc finger found in promyelocytic leukemia protein (PML) and similar proteins

cl00034
Location:191 → 239

Bbox_SF; B-box-type zinc finger superfamily

cl17238
Location:60 → 96

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006510864.5 → XP_006510927.1 protein PML isoform X4

UniProtKB/TrEMBL

D3YXR5

Conserved Domains (5) summary

cd00162
Location:62 → 96

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam12126
Location:244 → 580

DUF3583; Protein of unknown function (DUF3583)

cd19804
Location:131 → 173

Bbox1_TRIM19_C-V; B-box-type 1 zinc finger found in promyelocytic leukemia protein (PML) and similar proteins

cl00034
Location:191 → 239

Bbox_SF; B-box-type zinc finger superfamily

cl17238
Location:60 → 96

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006510862.5 → XP_006510925.1 protein PML isoform X3

UniProtKB/TrEMBL

D3YXR5

Conserved Domains (5) summary

cd00162
Location:62 → 96

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam12126
Location:244 → 580

DUF3583; Protein of unknown function (DUF3583)

cd19804
Location:131 → 173

Bbox1_TRIM19_C-V; B-box-type 1 zinc finger found in promyelocytic leukemia protein (PML) and similar proteins

cl00034
Location:191 → 239

Bbox_SF; B-box-type zinc finger superfamily

cl17238
Location:60 → 96

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain