Ncapg2 non-SMC condensin II complex, subunit G2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ncapg2provided by MGI
Official Full Name: non-SMC condensin II complex, subunit G2provided by MGI
Primary source: MGI:MGI:1923294
See related: Ensembl:ENSMUSG00000042029 AllianceGenome:MGI:1923294
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mtb; Luzp5; CAP-G2; mCAP-G2; 5830426I05Rik
Summary: Enables bHLH transcription factor binding activity. Involved in positive regulation of chromosome segregation and positive regulation of chromosome separation. Acts upstream of with a positive effect on erythrocyte differentiation. Acts upstream of with a negative effect on transcription by RNA polymerase II. Acts upstream of or within inner cell mass cell proliferation. Located in condensed nuclear chromosome. Part of condensin complex. Is active in nucleus. Is expressed in several structures, including axial musculature; brain; hemolymphoid system; liver; and nasal cavity epithelium. Orthologous to human NCAPG2 (non-SMC condensin II complex subunit G2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E14 (RPKM 10.5), liver E14.5 (RPKM 8.0) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F2; 12 62.65 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (116368969..116427152)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (116405351..116463532)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the condensin II subunit MTB/mCAP-G2 plays a novel function during erythropoiesis
Title: MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132799 (e-PCR)
- UniSTS:216082

NoName (e-PCR)
- UniSTS:224203

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bHLH transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables methylated histone binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_positive_effect erythrocyte differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within inner cell mass cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chromosome condensation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of condensin complex	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	NAS Non-traceable Author Statement more info	PubMed
part_of condensin complex	TAS Traceable Author Statement more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: condensin-2 complex subunit G2

Names: chromosome-associated protein G2; leucine zipper protein 5; more than blood protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133762.4 → NP_598523.3 condensin-2 complex subunit G2

See identical proteins and their annotated locations for NP_598523.3

Status: VALIDATED

Source sequence(s)

AC160634, AK081647, AK138871, AK139749, BB700949, BC076631, CK636577

Consensus CDS

CCDS26212.1

UniProtKB/Swiss-Prot

E9QP71, Q6DFV1, Q6SLL0, Q922D1

Related

ENSMUSP00000081889.4, ENSMUST00000084828.5

Conserved Domains (2) summary

sd00044
Location:376 → 404

HEAT; HEAT repeat [structural motif]

pfam12422
Location:213 → 360

Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

116368969..116427152

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157652.1 → XP_036013545.1 condensin-2 complex subunit G2 isoform X1

UniProtKB/Swiss-Prot

E9QP71, Q6DFV1, Q6SLL0, Q922D1

Conserved Domains (2) summary

sd00044
Location:376 → 404

HEAT; HEAT repeat [structural motif]

pfam12422
Location:213 → 360

Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
XM_036157653.1 → XP_036013546.1 condensin-2 complex subunit G2 isoform X2

Conserved Domains (1) summary

pfam12422
Location:213 → 360

Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
XM_006516356.2 → XP_006516419.1 condensin-2 complex subunit G2 isoform X3

Conserved Domains (2) summary

sd00044
Location:296 → 324

HEAT; HEAT repeat [structural motif]

pfam12422
Location:132 → 280

Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
XM_006516350.5 → XP_006516413.1 condensin-2 complex subunit G2 isoform X1

See identical proteins and their annotated locations for XP_006516413.1

UniProtKB/Swiss-Prot

E9QP71, Q6DFV1, Q6SLL0, Q922D1

Conserved Domains (2) summary

sd00044
Location:376 → 404

HEAT; HEAT repeat [structural motif]

pfam12422
Location:213 → 360

Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
XM_006516352.5 → XP_006516415.1 condensin-2 complex subunit G2 isoform X1

See identical proteins and their annotated locations for XP_006516415.1

UniProtKB/Swiss-Prot

E9QP71, Q6DFV1, Q6SLL0, Q922D1

Conserved Domains (2) summary

sd00044
Location:376 → 404

HEAT; HEAT repeat [structural motif]

pfam12422
Location:213 → 360

Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
XM_006516351.5 → XP_006516414.1 condensin-2 complex subunit G2 isoform X1

See identical proteins and their annotated locations for XP_006516414.1

UniProtKB/Swiss-Prot

E9QP71, Q6DFV1, Q6SLL0, Q922D1

Conserved Domains (2) summary

sd00044
Location:376 → 404

HEAT; HEAT repeat [structural motif]

pfam12422
Location:213 → 360

Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
XM_006516354.5 → XP_006516417.1 condensin-2 complex subunit G2 isoform X1

See identical proteins and their annotated locations for XP_006516417.1

UniProtKB/Swiss-Prot

E9QP71, Q6DFV1, Q6SLL0, Q922D1

Conserved Domains (2) summary

sd00044
Location:376 → 404

HEAT; HEAT repeat [structural motif]

pfam12422
Location:213 → 360

Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
XM_006516353.4 → XP_006516416.1 condensin-2 complex subunit G2 isoform X1

See identical proteins and their annotated locations for XP_006516416.1

UniProtKB/Swiss-Prot

E9QP71, Q6DFV1, Q6SLL0, Q922D1

Conserved Domains (2) summary

sd00044
Location:376 → 404

HEAT; HEAT repeat [structural motif]

pfam12422
Location:213 → 360

Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit