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    trf-2 MATH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172151, updated on 27-Dec-2024

    Summary

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    Official Symbol
    trf-2
    Official Full Name
    MATH domain-containing protein
    Primary source
    WormBase:WBGene00022454
    Locus tag
    CELE_Y110A7A.2
    See related
    AllianceGenome:WB:WBGene00022454
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TRAF1 (TNF receptor associated factor 1); TRAF3 (TNF receptor associated factor 3); and TRAF5 (TNF receptor associated factor 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See trf-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (5154514..5158500)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Thymidylate synthase Neighboring gene Acetylcholine receptor subunit alpha-type unc-63 Neighboring gene Piwi domain-containing protein Neighboring gene Small ribosomal subunit protein mS39

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans regulatory factor X (RFX) DAF-19M module: A shift from general ciliogenesis to cell-specific ciliary and behavioral specialization. Ahn S, et al. Cell Rep, 2022 Apr 12. PMID 35417689
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    MATH domain-containing protein
    NP_491534.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5154514..5158500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059133.3 → NP_491534.2  MATH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491534.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N586
      Conserved Domains (1) summary
      cd00270
      Location:158 → 304
      MATH_TRAF_C; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link cell surface TNFRs and receptors of the interleukin-1/Toll-like family to downstream kinase ...
    Nucleotide Protein
    Heading Accession and Version

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