Kif5c kinesin family member 5C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif5cprovided by RGD
Official Full Name: kinesin family member 5Cprovided by RGD
Primary source: RGD:1308539
See related: EnsemblRapid:ENSRNOG00000004680 AllianceGenome:RGD:1308539
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables ATP hydrolysis activity; apolipoprotein receptor binding activity; and microtubule binding activity. Involved in anterograde axonal protein transport and intracellular mRNA localization. Located in dendrite. Is active in GABA-ergic synapse and postsynaptic cytosol. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 2 and schizophrenia. Orthologous to human KIF5C (kinesin family member 5C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1006.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q12

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (54441266..54591630)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (34032082..34185597)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (35014157..35257417)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of miR-135a-5p Downregulation in Acute and Chronic Stress Response in the Prefrontal Cortex of Rats.
Title: Involvement of miR-135a-5p Downregulation in Acute and Chronic Stress Response in the Prefrontal Cortex of Rats.
A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression.
Title: A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression.
These results demonstrate that the neck linker serves as a mechanical element for kinesin-1 transport under physiological conditions.
Title: Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity.
We conclude that the enrichment of stable microtubules in the future axon enhances KIF5C-mediated vesicular transport of syntaxin 6 and VAMP4, which in turn mediates the polarized insertion of IGF-1r in the plasmalemma, a key step for neuronal polarization
Title: The Motor KIF5C Links the Requirements of Stable Microtubules and IGF-1 Receptor Membrane Insertion for Neuronal Polarization.
cargo recognition and concurrent activation of kinesin-1 proceed in hierarchical stepwise fashion driven by a dynamic network of inter- and intra-molecular interactions.
Title: SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain.
Kif5 plays a role in regulating mitochondrial morphology. Kif5c disruption was neuroprotective during excitotoxicity but not H2O2 toxicity.
Title: Kif5 regulates mitochondrial movement, morphology, function and neuronal survival.
Lysine 40 acetylation of alpha-tubulin does not result in significant changes in kinesin-1's landing rate or motility parameters.
Title: Effects of α-tubulin K40 acetylation and detyrosination on kinesin-1 motility in a purified system.
motility of Kinesin-1, preferential translocation of Kinesin-1 on axonal microtubules in polarized neurons is not determined by acetylation alone but probably specified by a combination of tubulin modifications
Title: Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons.
binding of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function
Title: Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE096005 (e-PCR)
- UniSTS:243978

PMC133732P1 (e-PCR)
- UniSTS:270641

RH142774 (e-PCR)
- UniSTS:232021

D3Got22 (e-PCR)
- UniSTS:112765

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables apolipoprotein receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
involved_in intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	ISO Inferred from Sequence Orthology more info
involved_in mRNA transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor neuron axon guidance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in ciliary rootlet	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in distal axon	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin heavy chain isoform 5C; kinesin heavy chain

Names: kinesin heavy chain neuron-specific 2; kinesin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107730.1 → NP_001101200.1 kinesin heavy chain isoform 5C

See identical proteins and their annotated locations for NP_001101200.1

Status: PROVISIONAL

Source sequence(s)

CH473983

UniProtKB/Swiss-Prot

G3V6L4, P56536

UniProtKB/TrEMBL

A0A0G2K070

Related

ENSRNOP00000006341.8, ENSRNOT00000006341.9

Conserved Domains (4) summary

smart00129
Location:8 → 334

KISc; Kinesin motor, catalytic domain. ATPase

cd01369
Location:6 → 327

KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup

pfam15619
Location:605 → 798

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

cl12013
Location:636 → 817

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

54441266..54591630

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283549.1 → XP_063139619.1 kinesin heavy chain isoform X1

UniProtKB/Swiss-Prot

G3V6L4, P56536

UniProtKB/TrEMBL

A0A0G2K070
XM_063283548.1 → XP_063139618.1 kinesin heavy chain isoform X1

UniProtKB/Swiss-Prot

G3V6L4, P56536

UniProtKB/TrEMBL

A0A0G2K070