Adamts19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adamts19provided by RGD
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 19provided by RGD
Primary source: RGD:1308359
See related: EnsemblRapid:ENSRNOG00000019577 AllianceGenome:RGD:1308359
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in heart valve morphogenesis and ventricular septum morphogenesis. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human ADAMTS19 (ADAM metallopeptidase with thrombospondin type 1 motif 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 73.6), Uterus (RPKM 22.7) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (54545357..54729184)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (52346448..52531245)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (53915807..54099856)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Adamts19 (e-PCR), detects polymorphism
- UniSTS:464652

AA946478 (e-PCR)
- UniSTS:250446

Adamts19 (e-PCR), detects polymorphism
- UniSTS:532647

AU027644 (e-PCR)
- UniSTS:113104

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	IEA Inferred from Electronic Annotation more info
involved_in collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitral valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in tricuspid valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 19

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108433.3 → NP_001101903.2 A disintegrin and metalloproteinase with thrombospondin motifs 19 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

D4A2E7

Related

ENSRNOP00000026543.6, ENSRNOT00000026543.7

Conserved Domains (5) summary

cd04273
Location:329 → 546

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:794 → 904

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:162 → 277

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:563 → 630

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:1095 → 1147

TSP1_ADAMTS; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

54545357..54729184

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277481.1 → XP_063133551.1 A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X3
XM_039096975.2 → XP_038952903.1 A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X1

Conserved Domains (2) summary

pfam05986
Location:283 → 393

ADAM_spacer1; ADAM-TS Spacer 1

pfam19030
Location:584 → 636

TSP1_ADAMTS; Thrombospondin type 1 domain
XM_063277480.1 → XP_063133550.1 A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X2