Gpsm1 G-protein signaling modulator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpsm1provided by RGD
Official Full Name: G-protein signaling modulator 1provided by RGD
Primary source: RGD:628682
See related: EnsemblRapid:ENSRNOG00000018666 AllianceGenome:RGD:628682
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ags3
Summary: Enables G-protein alpha-subunit binding activity. Involved in regulation of G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including Golgi membrane; endoplasmic reticulum membrane; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cell cortex. Orthologous to human GPSM1 (G protein signaling modulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 170.7), Brain (RPKM 75.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (29538929..29565921)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (9140816..9167828)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (3767394..3794360)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AGS3 reduced D(2L)DR-mediated sensitization of AC1 and AC2.
Title: Differential effects of AGS3 expression on D(2L) dopamine receptor-mediated adenylyl cyclase signaling.
This study demonistrated that the ags3 expression increassing in rat brain cortex after traumatic brain injury.
Title: Increased expression of AGS3 in rat brain cortex after traumatic brain injury.
These data suggest that Gpsm1 acts through a novel receptor-independent mechanism to facilitate renal tubular epithelial cell proliferation and renal tubular regeneration.
Title: Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents.
levels of AGS3 and USP9x are co-regulated in the prefrontal cortex of rats withdrawn from repeated cocaine treatment
Title: Identification of a deubiquitinating enzyme as a novel AGS3-interacting protein.
These data present AGS3, G-proteins, and mInsc as candidate proteins involved in regulating cellular stress associated with protein-processing pathologies.
Title: Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable.
AGS3 and G betagamma are hypothesized to gate the uncontrolled motivation to seek EtOH during abstinence
Title: Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma.
The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins.
Title: The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins.
Ric-8A has a role in catalyzing guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3
Title: Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3.
Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior.
Title: Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior.
Activates heterotimeric G protein signaling in a nucleotide exchange-independent manner.
Title: Receptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140521 (e-PCR)
- UniSTS:222590

RH130608 (e-PCR)
- UniSTS:213892

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein alpha-subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
enables GTPase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-protein-signaling modulator 1

Names: G-protein signaling modulator 1 (AGS3-like, C. elegans); G-protein signalling modulator 1 (AGS3-like, C. elegans); activator of G-protein signaling 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145469.1 → NP_001138941.1 G-protein-signaling modulator 1 isoform b

See identical proteins and their annotated locations for NP_001138941.1

Status: VALIDATED

Description

Transcript Variant: This variant (2, also known as AGS3-SHORT-1) differs in the 5' UTR, lacks several exons in the 5' coding region and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

BC086535

UniProtKB/TrEMBL

A6JTD5

Conserved Domains (1) summary

pfam02188
Location:88 → 107

GoLoco; GoLoco motif
NM_144745.2 → NP_653346.2 G-protein-signaling modulator 1 isoform a

See identical proteins and their annotated locations for NP_653346.2

Status: VALIDATED

Description

Transcript Variant: This variant (1, also known as AGS3-LONG) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AF107723, BC105302, BF408282, CB615566, CB743977

UniProtKB/Swiss-Prot

Q8K3E2, Q9R080

UniProtKB/TrEMBL

A6JTD0, G3V9X2

Related

ENSRNOP00000062075.1, ENSRNOT00000067840.4

Conserved Domains (5) summary

smart00390
Location:594 → 616

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

COG0457
Location:60 → 358

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:207 → 234

TPR; TPR repeat [structural motif]

pfam13424
Location:207 → 278

TPR_12; Tetratricopeptide repeat

pfam02188
Location:494 → 513

GoLoco; GoLoco motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

29538929..29565921

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104257.2 → XP_038960185.1 G-protein-signaling modulator 1 isoform X1

UniProtKB/Swiss-Prot

Q8K3E2, Q9R080

Conserved Domains (4) summary

COG0457
Location:50 → 358

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:207 → 234

TPR; TPR repeat [structural motif]

pfam13424
Location:207 → 278

TPR_12; Tetratricopeptide repeat

pfam02188
Location:494 → 513

GoLoco; GoLoco motif
XM_006233670.5 → XP_006233732.1 G-protein-signaling modulator 1 isoform X5

See identical proteins and their annotated locations for XP_006233732.1

UniProtKB/TrEMBL

A0A8I6AC91, A6JTD2, A6JTD4

Related

ENSRNOP00000089684.1, ENSRNOT00000102548.2

Conserved Domains (6) summary

smart00390
Location:626 → 648

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

sd00006
Location:239 → 266

TPR; TPR repeat [structural motif]

pfam00515
Location:138 → 170

TPR_1; Tetratricopeptide repeat

pfam02188
Location:526 → 547

GoLoco; GoLoco motif

pfam13176
Location:320 → 354

TPR_7; Tetratricopeptide repeat

pfam13424
Location:239 → 310

TPR_12; Tetratricopeptide repeat
XM_039104258.2 → XP_038960186.1 G-protein-signaling modulator 1 isoform X6

Conserved Domains (4) summary

COG0457
Location:76 → 237

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:86 → 113

TPR; TPR repeat [structural motif]

pfam13424
Location:86 → 157

TPR_12; Tetratricopeptide repeat

pfam02188
Location:373 → 392

GoLoco; GoLoco motif
XM_017591463.3 → XP_017446952.1 G-protein-signaling modulator 1 isoform X2
XM_008761620.4 → XP_008759842.1 G-protein-signaling modulator 1 isoform X3

UniProtKB/TrEMBL

A0A8L2R2Q0

Conserved Domains (2) summary

smart00390
Location:148 → 170

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

pfam02188
Location:48 → 69

GoLoco; GoLoco motif
XM_063283082.1 → XP_063139152.1 G-protein-signaling modulator 1 isoform X4

UniProtKB/TrEMBL

A6JTD5