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    INO80C INO80 complex subunit C [ Homo sapiens (human) ]

    Gene ID: 125476, updated on 10-Dec-2024

    Summary

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    Official Symbol
    INO80Cprovided by HGNC
    Official Full Name
    INO80 complex subunit Cprovided by HGNC
    Primary source
    HGNC:HGNC:26994
    See related
    Ensembl:ENSG00000153391 AllianceGenome:HGNC:26994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IES6; hIes6; C18orf37
    Summary
    Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Part of Ino80 complex and MLL1 complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 20.7), esophagus (RPKM 7.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See INO80C in Genome Data Viewer
    Location:
    18q12.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (35468333..35497960, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (35659720..35689378, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (33048297..33077924, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:33037967-33038794 Neighboring gene ZNF24 transcription regulator Neighboring gene GATA motif-containing MPRA enhancer 294 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:33058203-33059402 Neighboring gene Sharpr-MPRA regulatory region 729 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:33069875-33070595 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:33070661-33071322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:33071323-33071984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13226 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:33083620-33083814 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:33088818-33089400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13229 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 1 Neighboring gene microRNA 3975 Neighboring gene uncharacterized LOC105372065 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:33251128-33251300

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Yau EH, et al. Cancer Res, 2017 Nov 15. PMID 28954733, Free PMC Article
    2. The mammalian INO80 chromatin remodeling complex is required for replication stress recovery. Vassileva I, et al. Nucleic Acids Res, 2014 Aug. PMID 25016522, Free PMC Article
    3. INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer. Zhang S, et al. Oncogene, 2017 Mar. PMID 27641337, Free PMC Article
    4. Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability. Cao L, et al. PLoS One, 2015. PMID 26340092, Free PMC Article
    5. YY1 functions with INO80 to activate transcription. Cai Y, et al. Nat Struct Mol Biol, 2007 Sep. PMID 17721549

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ38183

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of telomere maintenance in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA strand elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MLL1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    INO80 complex subunit C
    Names
    IES6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098817.2 → NP_001092287.1  INO80 complex subunit C isoform 1

      See identical proteins and their annotated locations for NP_001092287.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BF475320, BM758571, BQ887287, BY800049
      Consensus CDS
      CCDS45853.1
      UniProtKB/Swiss-Prot
      Q6PI98
      Related
      ENSP00000391457.1, ENST00000441607.6
      Conserved Domains (1) summary
      cl02154
      Location:103 → 223
      YL1_C; YL1 nuclear protein C-terminal domain

    2. NM_001308064.2 → NP_001294993.1  INO80 complex subunit C isoform 3

      See identical proteins and their annotated locations for NP_001294993.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to isoform 1. The resulting protein (isoform 3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      BF475320, BQ441485
      Consensus CDS
      CCDS77177.1
      UniProtKB/TrEMBL
      K7EIY8
      Related
      ENSP00000464948.1, ENST00000586489.5
      Conserved Domains (1) summary
      cl02154
      Location:12 → 132
      YL1_C; YL1 nuclear protein C-terminal domain

    3. NM_194281.4 → NP_919257.2  INO80 complex subunit C isoform 2

      See identical proteins and their annotated locations for NP_919257.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      BF475320, BQ887287
      Consensus CDS
      CCDS11914.1
      UniProtKB/Swiss-Prot
      B4DUI4, E9PCS7, Q6PI98, Q86WR1, Q8N994
      Related
      ENSP00000334473.6, ENST00000334598.12
      Conserved Domains (1) summary
      cl02154
      Location:67 → 187
      YL1_C; YL1 nuclear protein C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      35468333..35497960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258196.6 → XP_005258253.1  INO80 complex subunit C isoform X2

      See identical proteins and their annotated locations for XP_005258253.1

      UniProtKB/TrEMBL
      K7EIY8
      Conserved Domains (1) summary
      cl02154
      Location:12 → 132
      YL1_C; YL1 nuclear protein C-terminal domain

    2. XM_011525812.4 → XP_011524114.1  INO80 complex subunit C isoform X1

      Conserved Domains (1) summary
      cl02154
      Location:41 → 161
      YL1_C; YL1 nuclear protein C-terminal domain

    3. XM_017025549.2 → XP_016881038.1  INO80 complex subunit C isoform X2

      UniProtKB/TrEMBL
      K7EIY8
      Conserved Domains (1) summary
      cl02154
      Location:12 → 132
      YL1_C; YL1 nuclear protein C-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      35659720..35689378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318192.1 → XP_054174167.1  INO80 complex subunit C isoform X1

    2. XM_054318193.1 → XP_054174168.1  INO80 complex subunit C isoform X2

      UniProtKB/TrEMBL
      K7EIY8

    3. XM_054318194.1 → XP_054174169.1  INO80 complex subunit C isoform X2

      UniProtKB/TrEMBL
      K7EIY8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PI98.1 GenPept UniProtKB/Swiss-Prot:Q6PI98

    Gene LinkOut

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