MPRIP myosin phosphatase Rho interacting protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: MPRIPprovided by HGNC
Official Full Name: myosin phosphatase Rho interacting proteinprovided by HGNC
Primary source: HGNC:HGNC:30321
See related: Ensembl:ENSG00000133030 MIM:612935; AllianceGenome:HGNC:30321
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRIP; RIP3; M-RIP; RHOIP3; p116Rip
Summary: Enables cadherin binding activity. Located in actin cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in endometrium (RPKM 19.8), brain (RPKM 18.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p11.2

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (17042457..17192643)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (16988540..17138696)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (16945771..17095957)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation and apoptosis of non-small cell lung cancer cells].
Title: [circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation and apoptosis of non-small cell lung cancer cells].
PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription.
Title: PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription.
The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus.
Title: The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus.
The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.
Title: The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.
Our data identify M-RIP as a crucial local regulator of the Rho-Rac balance during chemotaxis and antigen recognition.
Title: Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions.
MLCP (myosin light chain phosphatase) activation is counteracted by a previously unrecognized association between MRIP and the inducible kinase NUAK2
Title: An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers.
A functional analysis of JNK1 and M-RIP with RNA interference reveals a critical role for this cascade in the invasive behavior of cancer cells.
Title: M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.
p116Rip is an important regulatory component that controls the RhoA signaling pathway, thus regulating MLCP activity and myosin phosphorylation in cells
Title: p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA.
M-RIP-dependent targeting of myosin phosphatase to stress fibers has an important role in regulating myosin light chain phosphorylation state and morphology in human vascular smooth muscle cells
Title: M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis for severe diabetic retinopathy. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78418 (e-PCR)
- UniSTS:22025

G16017 (e-PCR)
- UniSTS:58411

SHGC-33713 (e-PCR)
- UniSTS:53549

D8S2279 (e-PCR)
- UniSTS:473907

RH24996 (e-PCR)
- UniSTS:83789

AF021130 (e-PCR)
- UniSTS:78420

D17S740 (e-PCR), detects polymorphism
- UniSTS:37725

STS-H00647 (e-PCR)
- UniSTS:25440

D1S1423 (e-PCR)
- UniSTS:149619

RH65251 (e-PCR)
- UniSTS:74365

D11S3114 (e-PCR)
- UniSTS:152207

D16S325 (e-PCR)
- UniSTS:147089

D17S1280 (e-PCR)
- UniSTS:78003

STS-D29495 (e-PCR)
- UniSTS:38338

D17S732 (e-PCR)
- UniSTS:62174

d01504sbk (e-PCR)
- UniSTS:96244

A004R11 (e-PCR)
- UniSTS:56061

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in focal adhesion	HDA more info	PubMed

General protein information

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Preferred Names: myosin phosphatase Rho-interacting protein

Names: Rho interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364716.4 → NP_001351645.2 myosin phosphatase Rho-interacting protein isoform 3

Status: VALIDATED

Source sequence(s)

AC055811, AC079111, AC104024

Consensus CDS

CCDS92265.1

UniProtKB/TrEMBL

A0A494BZV2

Related

ENSP00000498253.1, ENST00000651222.2

Conserved Domains (6) summary

PHA03307
Location:303 → 502

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:2061 → 2362

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01236
Location:16 → 151

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:508 → 609

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

TIGR02168
Location:797 → 1159

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:1860 → 2168

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
NM_015134.4 → NP_055949.2 myosin phosphatase Rho-interacting protein isoform 1

See identical proteins and their annotated locations for NP_055949.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC055811, AC079111, AC104024, AK092287, BC009982, BC136479

Consensus CDS

CCDS42268.1

UniProtKB/TrEMBL

B9EGI2

Related

ENSP00000379156.4, ENST00000395811.9

Conserved Domains (6) summary

cd01236
Location:16 → 151

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:390 → 491

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

pfam00169
Location:390 → 483

PH; PH domain

cd16269
Location:760 → 771

GBP_C; coiled coil [structural motif]

cl02488
Location:738 → 980

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:679 → 788

GBP_C; Guanylate-binding protein, C-terminal domain
NM_201274.4 → NP_958431.2 myosin phosphatase Rho-interacting protein isoform 2

See identical proteins and their annotated locations for NP_958431.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC055811, AC079111, AC104024, AY296247, BC075847, BE048871

Consensus CDS

CCDS32578.1

UniProtKB/Swiss-Prot

Q3KQZ5, Q5FB94, Q6DHW2, Q6WCQ1, Q7Z5Y2, Q8N390, Q96G40

UniProtKB/TrEMBL

B9EGI2

Related

ENSP00000342379.4, ENST00000341712.8

Conserved Domains (6) summary

cd01236
Location:16 → 151

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:390 → 491

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

pfam00169
Location:390 → 483

PH; PH domain

cd16269
Location:760 → 771

GBP_C; coiled coil [structural motif]

cl02488
Location:738 → 980

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:679 → 788

GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

17042457..17192643

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011523764.3 → XP_011522066.1 myosin phosphatase Rho-interacting protein isoform X2

Conserved Domains (9) summary

cd01236
Location:48 → 183

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:540 → 641

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

pfam00169
Location:540 → 633

PH; PH domain

pfam10473
Location:1062 → 1190

CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

pfam15619
Location:885 → 1036

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

pfam16043
Location:1048 → 1191

DUF4795; Domain of unknown function (DUF4795)

cl02488
Location:2157 → 2314

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl12013
Location:928 → 1117

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl19219
Location:2098 → 2198

DUF342; Protein of unknown function (DUF342)
XM_011523766.3 → XP_011522068.2 myosin phosphatase Rho-interacting protein isoform X5

UniProtKB/TrEMBL

B9EGI2
XM_047435685.1 → XP_047291641.1 myosin phosphatase Rho-interacting protein isoform X7

UniProtKB/TrEMBL

B9EGI2
XM_011523763.3 → XP_011522065.1 myosin phosphatase Rho-interacting protein isoform X1

Conserved Domains (8) summary

cd01236
Location:48 → 183

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:502 → 603

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

pfam00169
Location:502 → 595

PH; PH domain

pfam10473
Location:1024 → 1152

CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

pfam15619
Location:847 → 998

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

pfam16043
Location:1010 → 1153

DUF4795; Domain of unknown function (DUF4795)

cl03951
Location:2080 → 2179

CDC37_N; Cdc37 N terminal kinase binding

cl12013
Location:890 → 1079

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_047435684.1 → XP_047291640.1 myosin phosphatase Rho-interacting protein isoform X6

UniProtKB/TrEMBL

B9EGI2
XM_005256563.5 → XP_005256620.1 myosin phosphatase Rho-interacting protein isoform X3

Conserved Domains (7) summary

cd01236
Location:48 → 183

PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain

cd13275
Location:422 → 523

PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

pfam00169
Location:422 → 515

PH; PH domain

pfam10473
Location:944 → 1072

CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

pfam15619
Location:767 → 918

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

cl03951
Location:2000 → 2099

CDC37_N; Cdc37 N terminal kinase binding

cl12013
Location:828 → 999

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_047435683.1 → XP_047291639.1 myosin phosphatase Rho-interacting protein isoform X4
XM_047435686.1 → XP_047291642.1 myosin phosphatase Rho-interacting protein isoform X9

UniProtKB/TrEMBL

B9EGI2
XM_005256564.5 → XP_005256621.3 myosin phosphatase Rho-interacting protein isoform X8

UniProtKB/TrEMBL

B9EGI2

Related

ENSP00000462688.1, ENST00000584067.5

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

16988540..17138696

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054315583.1 → XP_054171558.1 myosin phosphatase Rho-interacting protein isoform X11
XM_054315586.1 → XP_054171561.1 myosin phosphatase Rho-interacting protein isoform X14

UniProtKB/TrEMBL

B9EGI2
XM_054315588.1 → XP_054171563.1 myosin phosphatase Rho-interacting protein isoform X16

UniProtKB/TrEMBL

B9EGI2
XM_054315582.1 → XP_054171557.1 myosin phosphatase Rho-interacting protein isoform X10
XM_054315587.1 → XP_054171562.1 myosin phosphatase Rho-interacting protein isoform X15

UniProtKB/TrEMBL

B9EGI2
XM_054315584.1 → XP_054171559.1 myosin phosphatase Rho-interacting protein isoform X12
XM_054315585.1 → XP_054171560.1 myosin phosphatase Rho-interacting protein isoform X13
XM_054315590.1 → XP_054171565.1 myosin phosphatase Rho-interacting protein isoform X18

UniProtKB/TrEMBL

B9EGI2
XM_054315589.1 → XP_054171564.1 myosin phosphatase Rho-interacting protein isoform X17

UniProtKB/TrEMBL

B9EGI2