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    Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64473, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bpnt1provided by RGD
    Official Full Name
    3'(2'), 5'-bisphosphate nucleotidase 1provided by RGD
    Primary source
    RGD:621833
    See related
    EnsemblRapid:ENSRNOG00000002378 AllianceGenome:RGD:621833
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sal3; RnPIP
    Summary
    Enables 3'(2'),5'-bisphosphate nucleotidase activity; inositol-1,4-bisphosphate 1-phosphatase activity; and magnesium ion binding activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to be located in mitochondrion. Orthologous to human BPNT1 (3'(2'), 5'-bisphosphate nucleotidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 248.0), Adrenal (RPKM 230.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bpnt1 in Genome Data Viewer
    Location:
    13q26
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (99397127..99425056)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (96865634..96893506)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (103268045..103292848)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene isoleucyl-tRNA synthetase 2, mitochondrial Neighboring gene microRNA 194-1 Neighboring gene microRNA 215 Neighboring gene uncharacterized LOC134481540 Neighboring gene glutamyl-prolyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC100911719 Neighboring gene solute carrier family 30, member 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity, 3'-phosphoadenosine 5'-phosphate phosphatase and inositol-polyphosphate 1-phosphatase. López-Coronado JM, et al. J Biol Chem, 1999 Jun 4. PMID 10347153
    2. Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy. Patel S, et al. J Mol Biol, 2002 Jan 25. PMID 11812139
    3. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. Spiegelberg BD, et al. J Biol Chem, 1999 May 7. PMID 10224133
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93112

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'(2'),5'-bisphosphate nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'(2'),5'-bisphosphate nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'(2'),5'-bisphosphate nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,4-bisphosphate 1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3'(2'),5'-bisphosphate nucleotidase 1
    Names
    3'-phosphoadenosine 5'-phosphate phosphatase
    BPntase 1
    PAP phosphatase
    PAP-inositol 1,4-phosphatase
    PIP
    bisphosphate 3'-nucleotidase 1
    inositol-polyphosphate 1-phosphatase
    scHAL2 analogous 3
    NP_741987.1
    XP_006250491.1
    XP_006250492.1
    XP_006250493.1
    XP_038946992.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_171990.2 → NP_741987.1  3'(2'),5'-bisphosphate nucleotidase 1

      See identical proteins and their annotated locations for NP_741987.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085692
      UniProtKB/Swiss-Prot
      Q9Z1N4
      UniProtKB/TrEMBL
      A0A8L2Q072, A6JGQ8
      Related
      ENSRNOP00000080410.2, ENSRNOT00000096481.2
      Conserved Domains (1) summary
      cd01640
      Location:11 → 297
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      99397127..99425056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091064.2 → XP_038946992.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0V3, A0A8L2Q072, A6JGQ7
      Conserved Domains (1) summary
      cd01640
      Location:11 → 312
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    2. XM_006250429.4 → XP_006250491.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006250491.1

      UniProtKB/TrEMBL
      A0A0G2K0V3, A0A8L2Q072, A6JGQ7
      Related
      ENSRNOP00000071594.1, ENSRNOT00000088921.3
      Conserved Domains (1) summary
      cd01640
      Location:11 → 312
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    3. XM_006250431.5 → XP_006250493.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X2

      See identical proteins and their annotated locations for XP_006250493.1

      UniProtKB/Swiss-Prot
      Q9Z1N4
      UniProtKB/TrEMBL
      A0A8L2Q072, A6JGQ8
      Conserved Domains (1) summary
      cd01640
      Location:11 → 297
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    4. XM_006250430.5 → XP_006250492.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006250492.1

      UniProtKB/TrEMBL
      A0A0G2K0V3, A0A8L2Q072, A6JGQ7
      Conserved Domains (1) summary
      cd01640
      Location:11 → 312
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1N4.1 GenPept UniProtKB/Swiss-Prot:Q9Z1N4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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