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    Sfxn4 sideroflexin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sfxn4provided by RGD
    Official Full Name
    sideroflexin 4provided by RGD
    Primary source
    RGD:1306088
    See related
    EnsemblRapid:ENSRNOG00000036572 AllianceGenome:RGD:1306088
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SLC64A4
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial transmembrane transport. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 18. Orthologous to human SFXN4 (sideroflexin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 43.4), Brain (RPKM 34.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sfxn4 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (269962527..269984849, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (259976480..259998778, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (282213610..282236851, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3, subunit A Neighboring gene uncharacterized LOC134485268 Neighboring gene DENN domain containing 10 Neighboring gene uncharacterized LOC134485269 Neighboring gene peroxiredoxin 3 Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene small nucleolar RNA SNORA44

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Kory N, et al. Science, 2018 Nov 16. PMID 30442778, Free PMC Article
    2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables monoatomic ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sideroflexin-4
    Names
    solute carrier family 64 member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108527.1 → NP_001101997.1  sideroflexin-4

      See identical proteins and their annotated locations for NP_001101997.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473986
      UniProtKB/TrEMBL
      A0A8I6A569, A6JIB0
      Conserved Domains (1) summary
      pfam03820
      Location:13 → 312
      Mtc; Tricarboxylate carrier

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      269962527..269984849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084760.2 → XP_038940688.1  sideroflexin-4 isoform X3

      Related
      ENSRNOP00000051558.4, ENSRNOT00000054674.5
      Conserved Domains (1) summary
      cl04275
      Location:16 → 290
      Mtc; Tricarboxylate carrier

    2. XM_006231684.5 → XP_006231746.1  sideroflexin-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A569, A0A8I6GFL8
      Conserved Domains (1) summary
      pfam03820
      Location:15 → 315
      Mtc; Tricarboxylate carrier

    3. XM_039084758.2 → XP_038940686.1  sideroflexin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A569, A0A8I6G785
      Related
      ENSRNOP00000082296.1, ENSRNOT00000103836.2
      Conserved Domains (1) summary
      cl04275
      Location:2 → 300
      Mtc; Tricarboxylate carrier

    4. XM_063268902.1 → XP_063124972.1  sideroflexin-4 isoform X5

    5. XM_063268909.1 → XP_063124979.1  sideroflexin-4 isoform X5

    6. XM_063268895.1 → XP_063124965.1  sideroflexin-4 isoform X4

    7. XM_039084761.2 → XP_038940689.1  sideroflexin-4 isoform X4

      Conserved Domains (1) summary
      cl04275
      Location:38 → 290
      Mtc; Tricarboxylate carrier

    RNA

    1. XR_005489366.2 RNA Sequence

    2. XR_005489383.2 RNA Sequence

    3. XR_010055168.1 RNA Sequence

    4. XR_010055167.1 RNA Sequence

    5. XR_010055169.1 RNA Sequence

    6. XR_005489406.2 RNA Sequence

    7. XR_005489405.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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