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    Slc38a5 solute carrier family 38, member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192208, updated on 3-Dec-2024

    Summary

    Official Symbol
    Slc38a5provided by RGD
    Official Full Name
    solute carrier family 38, member 5provided by RGD
    Primary source
    RGD:620702
    See related
    EnsemblRapid:ENSRNOG00000027767 AllianceGenome:RGD:620702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SN2
    Summary
    Enables L-amino acid transmembrane transporter activity and neutral amino acid, sodium:proton antiporter activity. Involved in L-amino acid transport and amino acid export across plasma membrane. Located in plasma membrane. Orthologous to human SLC38A5 (solute carrier family 38 member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 79.9), Spleen (RPKM 66.4) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc38a5 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (16885701..16894470, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14213727..14222498, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (14963919..14972675, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B630019K06 gene like Neighboring gene SSX family member 1 Neighboring gene small nucleolar RNA SNORA26 Neighboring gene ribosomal protein L29, pseudogene 21 Neighboring gene FtsJ RNA 2'-O-methyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-asparagine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-glutamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-glutamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-glutamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-glutamine, sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-glutamine, sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-glutamine, sodium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-glutamine, sodium:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables L-histidine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-histidine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-serine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-serine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neutral L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neutral amino acid, sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neutral amino acid, sodium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neutral amino acid, sodium:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in L-alanine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-glutamine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-glutamine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-glutamine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-glutamine import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in L-histidine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-histidine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-histidine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-serine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-serine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in amino acid export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in amino acid import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in asparagine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in asparagine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutamine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutamine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glutamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inorganic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neutral amino acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in serine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in serine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium-coupled neutral amino acid transporter 5
    Names
    amino acid transporter system N2
    system N transporter 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431696.1NP_001418625.1  sodium-coupled neutral amino acid transporter 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      A2VCW5, Q91XR7
      UniProtKB/TrEMBL
      A0A0H2UHW1, A6KP34
    2. NM_138854.2NP_620209.2  sodium-coupled neutral amino acid transporter 5 isoform 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0H2UHW1, A6KP35
      Related
      ENSRNOP00000073818.1, ENSRNOT00000079664.3
      Conserved Domains (1) summary
      cl00456
      Location:48458
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      16885701..16894470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008773068.4XP_008771290.2  sodium-coupled neutral amino acid transporter 5 isoform X1

      Related
      ENSRNOP00000038781.6, ENSRNOT00000038068.7
      Conserved Domains (1) summary
      cl00456
      Location:56466
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_039099444.2XP_038955372.1  sodium-coupled neutral amino acid transporter 5 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHW1
      Conserved Domains (1) summary
      cl00456
      Location:39449
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain