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    Fxyd2 FXYD domain-containing ion transport regulator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29639, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fxyd2provided by RGD
    Official Full Name
    FXYD domain-containing ion transport regulator 2provided by RGD
    Primary source
    RGD:2173
    See related
    EnsemblRapid:ENSRNOG00000016469 AllianceGenome:RGD:2173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ATP1C; Atp1g1; GNAKATP
    Summary
    This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. This gene, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. Related gene family members have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members, with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Two transcript variants have been described for this gene that encode distinct isoforms. [provided by RefSeq, Jan 2010]
    Expression
    Restricted expression toward (RPKM 3782.6) See more
    Orthologs
    NEW
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    Genomic context

    See Fxyd2 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54609658..54616788)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45712901..45720032)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49710334..49717492)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094137 Neighboring gene FXYD domain-containing ion transport regulator 6 Neighboring gene DS cell adhesion molecule-like 1 Neighboring gene centrosomal protein 164

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ion channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular hyperosmotic salinity response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in inorganic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular potassium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of P-type sodium:potassium-exchanging transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of P-type sodium:potassium-exchanging transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of P-type sodium:potassium-exchanging transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of sodium:potassium-exchanging ATPase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of sodium:potassium-exchanging ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium/potassium-transporting ATPase subunit gamma
    Names
    ATPase, Na+/K+ transporting, gamma 1 polypeptide
    FXTD domain-containing ion transport regulator 2
    Na(+)/K(+) ATPase subunit gamma
    gamma subunit of sodium potassium ATPase
    sodium pump gamma chain
    sodium/potassium-transporting ATPase gamma chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017349.3NP_059045.2  sodium/potassium-transporting ATPase subunit gamma isoform b

      See identical proteins and their annotated locations for NP_059045.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) contains an alternate exon in the 5' coding region and 5' UTR, compared to variant a. This results in a shorter protein (isoform b) that has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8L2QTU3, A6J442
      Related
      ENSRNOP00000061133.3, ENSRNOT00000064611.5
      Conserved Domains (1) summary
      cd20318
      Location:850
      FXYD2; FXYD domain-containing ion transport regulator 2
    2. NM_145717.2NP_663769.1  sodium/potassium-transporting ATPase subunit gamma isoform a

      See identical proteins and their annotated locations for NP_663769.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) encodes the longer isoform (a).
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q04679, Q9JKN3, Q9WUD3
      UniProtKB/TrEMBL
      A0A8L2QTU3, A6J444
      Related
      ENSRNOP00000109670.1, ENSRNOT00000168026.1
      Conserved Domains (1) summary
      cd20318
      Location:1052
      FXYD2; FXYD domain-containing ion transport regulator 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      54609658..54616788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)