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    Wtip WT1 interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361552, updated on 27-Dec-2024

    Summary

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    Symbol
    Wtipprovided by RGD
    Full Name
    WT1 interacting proteinprovided by RGD
    Primary source
    RGD:1306411
    See related
    AllianceGenome:RGD:1306411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306411; AABR07002945.1
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; regulation of gene expression; and response to hypoxia. Predicted to act upstream of or within miRNA-mediated post-transcriptional gene silencing. Predicted to be part of transcription regulator complex. Predicted to be active in P-body; adherens junction; and nucleus. Orthologous to human WTIP (WT1 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 91.5), Kidney (RPKM 70.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wtip in Genome Data Viewer
    Location:
    1q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95868399..95902117, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86731214..86764939, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89966496..89999892, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene karyopherin subunit alpha 3, pseudogene 1 Neighboring gene secretoglobin, family 1B, member 30 Neighboring gene small nucleolar RNA SNORA11 Neighboring gene ubiquitin-like modifier activating enzyme 2 Neighboring gene programmed cell death 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling. Ayyanathan K, et al. Cancer Res, 2007 Oct 1. PMID 17909014
    2. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Das Thakur M, et al. Curr Biol, 2010 Apr 13. PMID 20303269, Free PMC Article
    3. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Foxler DE, et al. Nat Cell Biol, 2012 Jan 29. PMID 22286099
    4. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. James V, et al. Proc Natl Acad Sci U S A, 2010 Jul 13. PMID 20616046, Free PMC Article
    5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA-mediated gene silencing by inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Wilms tumor protein 1-interacting protein
    Names
    Wilms tumor 1 interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400841.1 → NP_001387770.1  Wilms tumor protein 1-interacting protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1LMC1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95868399..95902117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266515.1 → XP_063122585.1  Wilms tumor protein 1-interacting protein isoform X2

      UniProtKB/TrEMBL
      A6JA84

    2. XM_017590047.3 → XP_017445536.1  Wilms tumor protein 1-interacting protein isoform X2

      UniProtKB/TrEMBL
      A6JA84

    3. XM_039100857.2 → XP_038956785.1  Wilms tumor protein 1-interacting protein isoform X1

      Conserved Domains (3) summary
      cd09352
      Location:192 → 245
      LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins
      cd09355
      Location:257 → 309
      LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins
      PRK07003
      Location:23 → 185
      PRK07003; DNA polymerase III subunit gamma/tau

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108196.1: Suppressed sequence

      Description
      NM_001108196.1: This RefSeq was removed because it contains the wrong CDS.
    Nucleotide Protein Strain
    Heading Accession and Version

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