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    Arfgap2 ARF GTPase activating protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 77038, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arfgap2provided by MGI
    Official Full Name
    ARF GTPase activating protein 2provided by MGI
    Primary source
    MGI:MGI:1924288
    See related
    Ensembl:ENSMUSG00000027255 AllianceGenome:MGI:1924288
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp289; 2310032E02Rik
    Summary
    This gene encodes a zinc-finger-containing GTPase-activating protein for ADP ribosylation factor 1 (ARF1), a small GTPase that plays a role in coatomer-mediated vesicular trafficking. This gene product stimulates the hydrolysis of ARF1-bound GTP, which may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. It may regulate the retrograde transport from the Golgi complex to the endoplasmic reticulum. Expression of this gene has been shown to be controlled by inhibitor of DNA binding 1 (Id1). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 6. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in thymus adult (RPKM 21.9), liver adult (RPKM 21.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arfgap2 in Genome Data Viewer
    Location:
    2 E1; 2 50.62 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91095460..91107716)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91265115..91277371)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31054 Neighboring gene STARR-positive B cell enhancer ABC_E3385 Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91148974-91149175 Neighboring gene STARR-seq mESC enhancer starr_05115 Neighboring gene predicted gene 13787 Neighboring gene STARR-positive B cell enhancer ABC_E9518 Neighboring gene low density lipoprotein receptor-related protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a zinc finger protein involved in Id-1-stimulated mammary epithelial cell growth. Singh J, et al. J Biol Chem, 2001 Apr 13. PMID 11278321
    2. Characterization of gene expression in mouse blastocyst using single-pass sequencing of 3995 clones. Sasaki N, et al. Genomics, 1998 Apr 15. PMID 9598303
    3. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Tkatchenko TV, et al. Physiol Genomics, 2009 Nov 6. PMID 19723774, Free PMC Article
    4. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPI coating of Golgi vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor GTPase-activating protein 2
    Names
    ADP-ribosylation factor GTPase activating protein 2
    ARF GAP 2
    GTPase-activating protein ZNF289
    zinc finger protein 289

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166024.1 → NP_001159496.1  ADP-ribosylation factor GTPase-activating protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001159496.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK009565, AK141749, AK169144, AL732478, BY648993
      Consensus CDS
      CCDS50639.1
      UniProtKB/Swiss-Prot
      Q99K28
      UniProtKB/TrEMBL
      Q3UR67
      Related
      ENSMUSP00000028691.7, ENSMUST00000028691.7
      Conserved Domains (2) summary
      PLN03114
      Location:3 → 484
      PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
      pfam01412
      Location:11 → 117
      ArfGap; Putative GTPase activating protein for Arf

    2. NM_023854.2 → NP_076343.2  ADP-ribosylation factor GTPase-activating protein 2 isoform 2

      See identical proteins and their annotated locations for NP_076343.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AK141749, AK169144, AL732478, BY648993
      Consensus CDS
      CCDS16430.1
      UniProtKB/Swiss-Prot
      Q99K28, Q9D758, Q9JIH1
      Related
      ENSMUSP00000078920.7, ENSMUST00000080008.13
      Conserved Domains (2) summary
      PLN03114
      Location:3 → 470
      PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
      pfam01412
      Location:11 → 117
      ArfGap; Putative GTPase activating protein for Arf

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      91095460..91107716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99K28.1 GenPept UniProtKB/Swiss-Prot:Q99K28

    Gene LinkOut

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