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    Srek1 splicing regulatory glutamic acid and lysine rich protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56763, updated on 3-Dec-2024

    Summary

    Official Symbol
    Srek1provided by RGD
    Official Full Name
    splicing regulatory glutamic acid and lysine rich protein 1provided by RGD
    Primary source
    RGD:621696
    See related
    EnsemblRapid:ENSRNOG00000032735 AllianceGenome:RGD:621696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sfrs12; Srrp86; Srsf12
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of spliceosomal complex. Orthologous to human SREK1 (splicing regulatory glutamic acid and lysine rich protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 166.6), Thymus (RPKM 153.7) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Srek1 in Genome Data Viewer
    Location:
    2q13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (36583412..36618978, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (34849548..34885120, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (33806035..33841594, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase family member 4 Neighboring gene uncharacterized LOC120101077 Neighboring gene uncharacterized LOC120100556 Neighboring gene erbb2 interacting protein Neighboring gene AKT interacting protein, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    splicing regulatory glutamine/lysine-rich protein 1
    Names
    SR-related protein of 86 kDa
    serine/arginine-rich splicing factor 12
    serine/arginine-rich-splicing regulatory protein 86
    splicing factor, arginine/serine-rich 12
    splicing regulatory glutamic acid/lysine-rich protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412515.1NP_001399444.1  splicing regulatory glutamine/lysine-rich protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6A4G5, A0A8I6AGJ5, A6I5E3
      Related
      ENSRNOP00000093834.1, ENSRNOT00000098044.2
    2. NM_020092.2NP_064477.2  splicing regulatory glutamine/lysine-rich protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9JKL7
      UniProtKB/TrEMBL
      A6I5E4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      36583412..36618978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102993.2XP_038958921.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGJ5
      Related
      ENSRNOP00000085824.2, ENSRNOT00000102302.2
      Conserved Domains (2) summary
      cd12260
      Location:178263
      RRM2_SREK1; RNA recognition motif 2 (RRM2) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
      cd12519
      Location:2099
      RRM1_SREK1; RNA recognition motif 1 (RRM1) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
    2. XM_063282421.1XP_063138491.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q9JKL7
      UniProtKB/TrEMBL
      A6I5E4
    3. XM_039102994.2XP_038958922.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q9JKL7
      Conserved Domains (1) summary
      cd12260
      Location:62147
      RRM2_SREK1; RNA recognition motif 2 (RRM2) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
    4. XM_063282422.1XP_063138492.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X4