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    Pacsin2 protein kinase C and casein kinase substrate in neurons 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 124461, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pacsin2provided by RGD
    Official Full Name
    protein kinase C and casein kinase substrate in neurons 2provided by RGD
    Primary source
    RGD:69411
    See related
    EnsemblRapid:ENSRNOG00000009756 AllianceGenome:RGD:69411
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SdpII
    Summary
    Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and phosphatidic acid binding activity. Predicted to be involved in several processes, including caveolin-mediated endocytosis; plasma membrane organization; and protein localization to endosome. Predicted to act upstream of or within negative regulation of endocytosis. Predicted to be located in several cellular components, including centriolar satellite; nuclear speck; and recycling endosome membrane. Predicted to be active in endosome; glutamatergic synapse; and plasma membrane. Orthologous to human PACSIN2 (protein kinase C and casein kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 141.9), Kidney (RPKM 114.7) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pacsin2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116385571..116478609, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114505525..114599087, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124224210..124317407, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene alpha 1,4-galactosyltransferase Neighboring gene ARF GTPase activating protein 3 Neighboring gene uncharacterized LOC120093699 Neighboring gene TTL family tubulin polyglutamylase complex subunit L1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in caveola assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in caveola assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in caveola assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in caveolin-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in caveolin-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in caveolin-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in plasma membrane tubulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasma membrane tubulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to endosome IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein kinase C and casein kinase substrate in neurons 2 protein
    Names
    SdpIIsyndapin II
    synaptic dynamin-associated protein II
    syndapin-2
    syndapin-II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130740.2NP_570096.2  protein kinase C and casein kinase substrate in neurons 2 protein

      See identical proteins and their annotated locations for NP_570096.2

      Status: PROVISIONAL

      Source sequence(s)
      BC070911
      UniProtKB/Swiss-Prot
      Q9QY17, Q9QY18, Q9QY19, Q9QY20
      UniProtKB/TrEMBL
      Q6IRI3
      Related
      ENSRNOP00000072822.2, ENSRNOT00000088125.3
      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      116385571..116478609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242055.4XP_006242117.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X4

      See identical proteins and their annotated locations for XP_006242117.1

      UniProtKB/Swiss-Prot
      Q9QY17, Q9QY18, Q9QY19, Q9QY20
      UniProtKB/TrEMBL
      Q6IRI3
      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    2. XM_063262926.1XP_063118996.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X7

      UniProtKB/TrEMBL
      A0A8L2QT84
    3. XM_063262920.1XP_063118990.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X5

      UniProtKB/Swiss-Prot
      Q9QY17, Q9QY18, Q9QY19, Q9QY20
    4. XM_063262921.1XP_063118991.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X6

      UniProtKB/TrEMBL
      A0A8L2QT84, A6HT91
      Related
      ENSRNOP00000013398.7, ENSRNOT00000013398.10
    5. XM_039078308.2XP_038934236.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X4

      UniProtKB/Swiss-Prot
      Q9QY17, Q9QY18, Q9QY19, Q9QY20
      UniProtKB/TrEMBL
      Q6IRI3
      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    6. XM_063262924.1XP_063118994.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X5

      UniProtKB/Swiss-Prot
      Q9QY17, Q9QY18, Q9QY19, Q9QY20
    7. XM_063262918.1XP_063118988.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X4

      UniProtKB/Swiss-Prot
      Q9QY17, Q9QY18, Q9QY19, Q9QY20
      UniProtKB/TrEMBL
      Q6IRI3
    8. XM_039078309.2XP_038934237.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X4

      UniProtKB/Swiss-Prot
      Q9QY17, Q9QY18, Q9QY19, Q9QY20
      UniProtKB/TrEMBL
      Q6IRI3
      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    9. XM_063262923.1XP_063118993.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X6

      UniProtKB/TrEMBL
      A0A8L2QT84, A6HT91
    10. XM_063262922.1XP_063118992.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X6

      UniProtKB/TrEMBL
      A0A8L2QT84, A6HT91
    11. XM_063262917.1XP_063118987.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X4

      UniProtKB/Swiss-Prot
      Q9QY17, Q9QY18, Q9QY19, Q9QY20
      UniProtKB/TrEMBL
      Q6IRI3
    12. XM_063262916.1XP_063118986.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X2

      UniProtKB/Swiss-Prot
      Q9QY17, Q9QY18, Q9QY19, Q9QY20
    13. XM_039078307.2XP_038934235.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X3

      UniProtKB/Swiss-Prot
      Q9QY17, Q9QY18, Q9QY19, Q9QY20
      Conserved Domains (2) summary
      cd07679
      Location:63318
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    14. XM_039078304.2XP_038934232.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X1

      UniProtKB/Swiss-Prot
      Q9QY17, Q9QY18, Q9QY19, Q9QY20
      UniProtKB/TrEMBL
      A0A8I6A2Y6
      Related
      ENSRNOP00000087304.1, ENSRNOT00000111896.2
      Conserved Domains (2) summary
      cd07679
      Location:63318
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:472527
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    15. XM_063262925.1XP_063118995.1  protein kinase C and casein kinase substrate in neurons 2 protein isoform X5

      UniProtKB/Swiss-Prot
      Q9QY17, Q9QY18, Q9QY19, Q9QY20