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    Hoxc4 homeo box C4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24459, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hoxc4provided by RGD
    Official Full Name
    homeo box C4provided by RGD
    Primary source
    RGD:1586210
    See related
    EnsemblRapid:ENSRNOG00000016613 AllianceGenome:RGD:1586210
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hox3r3
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to glial cell derived neurotrophic factor and positive regulation of male germ-line stem cell asymmetric division. Predicted to be located in nucleoplasm. Orthologous to human HOXC4 (homeobox C4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 26.5), Uterus (RPKM 14.3) and 5 other tissues See more
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    Genomic context

    See Hoxc4 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136049059..136051601)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134135279..134173133)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144646605..144652589)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene homeobox C8 Neighboring gene homeo box C6 Neighboring gene microRNA 615 Neighboring gene homeo box C5 Neighboring gene uncharacterized LOC102547409 Neighboring gene uncharacterized LOC102547667

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    homeobox protein Hox-C4
    Names
    Homeobox gene C4
    homeobox protein R3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109884.1NP_001103354.1  homeobox protein Hox-C4

      See identical proteins and their annotated locations for NP_001103354.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KCZ2, D3ZK87
      Related
      ENSRNOP00000022398.3, ENSRNOT00000022398.6
      Conserved Domains (1) summary
      pfam00046
      Location:159213
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      136049059..136051601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)