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    Cask calcium/calmodulin dependent serine protein kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29647, updated on 3-Dec-2024

    Summary

    Symbol
    Caskprovided by RGD
    Full Name
    calcium/calmodulin dependent serine protein kinaseprovided by RGD
    Primary source
    RGD:62004
    See related
    EnsemblRapid:ENSRNOG00000060946 AllianceGenome:RGD:62004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables PDZ domain binding activity; neurexin family protein binding activity; and protein kinase C binding activity. Involved in several processes, including positive regulation of dendritic spine morphogenesis; positive regulation of insulin secretion; and protein localization to plasma membrane. Located in several cellular components, including apical dendrite; basolateral plasma membrane; and podocyte foot. Part of protein-containing complex. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/calmodulin dependent serine protein kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 149.8), Adrenal (RPKM 92.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cask in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (11572328..11915831)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (8899500..9243014)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (9815652..10156155)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene SNW domain containing 1, pseudogene 6 Neighboring gene transfer RNA glutamine (anticodon UUG) 5 Neighboring gene uncharacterized LOC120099226 Neighboring gene G protein-coupled receptor 82 Neighboring gene G protein-coupled receptor 34 Neighboring gene transfer RNA aspartic acid (anticodon GUC) 13 Neighboring gene nyctalopin Neighboring gene uncharacterized LOC120099244

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurexin family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurexin family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables neurexin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion import IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion import IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear lamina ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in podocyte foot IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peripheral plasma membrane protein CASK
    Names
    calcium/calmodulin-dependent serine protein kinase (MAGUK family)
    peripheral plasma membrane protein CASK-like
    XP_038955486.1
    XP_038955487.1
    XP_038955488.1
    XP_038955489.1
    XP_038955490.1
    XP_038955491.1
    XP_038955492.1
    XP_038955493.1
    XP_038955494.1
    XP_038955495.1
    XP_063135934.1
    XP_063135935.1
    XP_063135937.1
    XP_063135938.1
    XP_063135939.1
    XP_063135940.1
    XP_063135941.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431578.1NP_001418507.1  peripheral plasma membrane protein CASK isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6APQ1
    2. NM_001431579.1NP_001418508.1  peripheral plasma membrane protein CASK isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6APQ1
    3. NM_022184.2NP_071520.2  peripheral plasma membrane protein CASK isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q62915
      UniProtKB/TrEMBL
      A0A0G2K2L8
      Related
      ENSRNOP00000072295.2, ENSRNOT00000091382.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      11572328..11915831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279864.1XP_063135934.1  peripheral plasma membrane protein CASK isoform X2

      UniProtKB/Swiss-Prot
      Q62915
    2. XM_039099558.2XP_038955486.1  peripheral plasma membrane protein CASK isoform X1

      UniProtKB/TrEMBL
      A6JZX5
      Conserved Domains (6) summary
      smart00569
      Location:354407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:622683
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:744917
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412462
      L27; L27 domain
    3. XM_039099563.2XP_038955491.1  peripheral plasma membrane protein CASK isoform X7

      UniProtKB/TrEMBL
      A6JZX5
      Conserved Domains (6) summary
      smart00569
      Location:354407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:610671
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:732905
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412462
      L27; L27 domain
    4. XM_063279869.1XP_063135939.1  peripheral plasma membrane protein CASK isoform X14

      UniProtKB/TrEMBL
      A6JZX6
    5. XM_063279867.1XP_063135937.1  peripheral plasma membrane protein CASK isoform X10

      UniProtKB/TrEMBL
      A0A8I6APQ1
      Related
      ENSRNOP00000095774.2, ENSRNOT00000099608.2
    6. XM_039099560.2XP_038955488.1  peripheral plasma membrane protein CASK isoform X4

      UniProtKB/TrEMBL
      A6JZX5
      Related
      ENSRNOP00000096945.2, ENSRNOT00000097626.2
      Conserved Domains (6) summary
      smart00569
      Location:348401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:738911
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406456
      L27; L27 domain
    7. XM_063279865.1XP_063135935.1  peripheral plasma membrane protein CASK isoform X8

      UniProtKB/TrEMBL
      A6JZX5
    8. XM_039099561.2XP_038955489.1  peripheral plasma membrane protein CASK isoform X5

      UniProtKB/Swiss-Prot
      Q62915
      UniProtKB/TrEMBL
      A0A8I6GLU3
      Conserved Domains (6) summary
      smart00569
      Location:348401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:733906
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406456
      L27; L27 domain
    9. XM_039099564.2XP_038955492.1  peripheral plasma membrane protein CASK isoform X9

      UniProtKB/TrEMBL
      A0A8I6APQ1
      Conserved Domains (6) summary
      smart00569
      Location:354407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:599660
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:721894
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412462
      L27; L27 domain
    10. XM_039099559.2XP_038955487.1  peripheral plasma membrane protein CASK isoform X3

      UniProtKB/TrEMBL
      A6JZX4, A6JZX5
      Related
      ENSRNOP00000004187.8, ENSRNOT00000004187.8
      Conserved Domains (6) summary
      smart00569
      Location:348401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:738911
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406456
      L27; L27 domain
    11. XM_063279868.1XP_063135938.1  peripheral plasma membrane protein CASK isoform X11

      UniProtKB/TrEMBL
      A0A8I6APQ1
    12. XM_039099565.2XP_038955493.1  peripheral plasma membrane protein CASK isoform X12

      UniProtKB/TrEMBL
      A0A8I6APQ1
      Conserved Domains (6) summary
      smart00569
      Location:348401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:593654
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:710883
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406456
      L27; L27 domain
    13. XM_039099562.2XP_038955490.1  peripheral plasma membrane protein CASK isoform X6

      UniProtKB/TrEMBL
      A6JZX5, D4A8M2
      Conserved Domains (6) summary
      smart00569
      Location:342395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:610671
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:732905
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400450
      L27; L27 domain
    14. XM_039099567.2XP_038955495.1  peripheral plasma membrane protein CASK isoform X17

      UniProtKB/TrEMBL
      A6JZX6
      Conserved Domains (6) summary
      smart00569
      Location:342395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:575636
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:692865
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400450
      L27; L27 domain
    15. XM_063279870.1XP_063135940.1  peripheral plasma membrane protein CASK isoform X15

    16. XM_063279871.1XP_063135941.1  peripheral plasma membrane protein CASK isoform X16

      UniProtKB/TrEMBL
      A0A0G2K8F4, A6JZX6
      Related
      ENSRNOP00000074587.2, ENSRNOT00000082316.3
    17. XM_039099566.2XP_038955494.1  peripheral plasma membrane protein CASK isoform X13

      Conserved Domains (6) summary
      smart00569
      Location:342395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:587648
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:709882
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400450
      L27; L27 domain