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    Arih2 ariadne RBR E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

    Gene ID: 23807, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arih2provided by MGI
    Official Full Name
    ariadne RBR E3 ubiquitin protein ligase 2provided by MGI
    Primary source
    MGI:MGI:1344361
    See related
    Ensembl:ENSMUSG00000064145 AllianceGenome:MGI:1344361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARI2; UIP48; TRIAD1
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of Cul5-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.8), thymus adult (RPKM 11.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Arih2 in Genome Data Viewer
    Location:
    9 F2; 9 59.54 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108480141..108531917, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108602942..108653681, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_25213 Neighboring gene STARR-seq mESC enhancer starr_25214 Neighboring gene WD repeat domain 6 Neighboring gene prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:108551788-108551897 Neighboring gene STARR-seq mESC enhancer starr_25220 Neighboring gene STARR-positive B cell enhancer ABC_E8317 Neighboring gene solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 Neighboring gene protein kinase, cAMP dependent regulatory, type II alpha Neighboring gene STARR-seq mESC enhancer starr_25223 Neighboring gene predicted gene, 24259

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in developmental cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in developmental cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hematopoietic stem cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul5-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ARIH2
    Names
    ARI-2
    RING-type E3 ubiquitin transferase ARIH2
    ariadne 2
    ariadne homolog 2
    protein ariadne-2 homolog
    ubcM4-interacting protein 48
    NP_001344212.1
    NP_001344214.1
    NP_001344215.1
    NP_001407995.1
    NP_035920.1
    XP_011241183.1
    XP_030100211.1
    XP_030100212.1
    XP_036010821.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357283.2NP_001344212.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      CT571271
      Consensus CDS
      CCDS23534.1
      UniProtKB/Swiss-Prot
      Q9Z1K6
      UniProtKB/TrEMBL
      Q3TK92
      Conserved Domains (3) summary
      smart00647
      Location:207269
      IBR; In Between Ring fingers
      cd16773
      Location:136189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297329
      IBR; IBR domain, a half RING-finger domain
    2. NM_001357285.1NP_001344214.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AK167104, BC051998, CT571271
      Consensus CDS
      CCDS23534.1
      UniProtKB/Swiss-Prot
      Q9Z1K6
      UniProtKB/TrEMBL
      Q3TK92
      Conserved Domains (3) summary
      smart00647
      Location:207269
      IBR; In Between Ring fingers
      cd16773
      Location:136189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297329
      IBR; IBR domain, a half RING-finger domain
    3. NM_001357286.2NP_001344215.1  E3 ubiquitin-protein ligase ARIH2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.z
      Source sequence(s)
      CT571271
      Conserved Domains (3) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226258
      IBR; IBR domain, a half RING-finger domain
    4. NM_001421066.1NP_001407995.1  E3 ubiquitin-protein ligase ARIH2 isoform b

      Status: VALIDATED

      Source sequence(s)
      CT571271
    5. NM_011790.6NP_035920.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      See identical proteins and their annotated locations for NP_035920.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      CT571271
      Consensus CDS
      CCDS23534.1
      UniProtKB/Swiss-Prot
      Q9Z1K6
      UniProtKB/TrEMBL
      Q3TK92
      Related
      ENSMUSP00000013338.9, ENSMUST00000013338.14
      Conserved Domains (3) summary
      smart00647
      Location:207269
      IBR; In Between Ring fingers
      cd16773
      Location:136189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297329
      IBR; IBR domain, a half RING-finger domain

    RNA

    1. NR_151664.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CT571271

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108480141..108531917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244352.1XP_030100212.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z1K6
      UniProtKB/TrEMBL
      Q3TK92
      Conserved Domains (3) summary
      smart00647
      Location:207269
      IBR; In Between Ring fingers
      cd16773
      Location:136189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297329
      IBR; IBR domain, a half RING-finger domain
    2. XM_030244351.2XP_030100211.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z1K6
      UniProtKB/TrEMBL
      Q3TK92
      Conserved Domains (3) summary
      smart00647
      Location:207269
      IBR; In Between Ring fingers
      cd16773
      Location:136189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:297329
      IBR; IBR domain, a half RING-finger domain
    3. XM_036154928.1XP_036010821.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

      Conserved Domains (3) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226258
      IBR; IBR domain, a half RING-finger domain
    4. XM_011242881.4XP_011241183.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      UniProtKB/TrEMBL
      A0A0A6YXB0
      Related
      ENSMUSP00000141914.2, ENSMUST00000193190.6
      Conserved Domains (2) summary
      smart00647
      Location:207269
      IBR; In Between Ring fingers
      cd16773
      Location:136189
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)