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    Nmrk2 nicotinamide riboside kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 69564, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nmrk2provided by MGI
    Official Full Name
    nicotinamide riboside kinase 2provided by MGI
    Primary source
    MGI:MGI:1916814
    See related
    Ensembl:ENSMUSG00000004939 AllianceGenome:MGI:1916814
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mibp; Itgb1bp3; 2310015C21Rik
    Summary
    Predicted to enable ribosylnicotinamide kinase activity and ribosylnicotinate kinase activity. Acts upstream of or within negative regulation of myoblast differentiation. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; lung; skeletal muscle tissue; and thymus. Orthologous to human NMRK2 (nicotinamide riboside kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 4.7), mammary gland adult (RPKM 1.1) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Nmrk2 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81034004..81037871, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81198170..81202265, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene death-associated protein kinase 3 Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene ataxia, cerebellar, Cayman type Neighboring gene zinc finger RNA binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nicotinate riboside kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosylnicotinamide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosylnicotinamide kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosylnicotinamide kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosylnicotinate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular anatomical structure IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nicotinamide riboside kinase 2
    Names
    NRK 2
    RNK 2
    integrin beta 1 binding protein 3
    muscle integrin-binding protein
    muscle-specific beta 1 integrin binding protein
    nicotinic acid riboside kinase 2
    nmR-K 2
    ribosylnicotinamide kinase 2
    ribosylnicotinic acid kinase 2
    NP_081396.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027120.2NP_081396.1  nicotinamide riboside kinase 2

      See identical proteins and their annotated locations for NP_081396.1

      Status: PROVISIONAL

      Source sequence(s)
      AK137483
      Consensus CDS
      CCDS24046.1
      UniProtKB/Swiss-Prot
      Q0VEG2, Q3UV96, Q9D7C9
      Related
      ENSMUSP00000005069.7, ENSMUST00000005069.8
      Conserved Domains (1) summary
      cd02024
      Location:4164
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81034004..81037871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)