U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tekt4 tektin 4 [ Mus musculus (house mouse) ]

    Gene ID: 71840, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tekt4provided by MGI
    Official Full Name
    tektin 4provided by MGI
    Primary source
    MGI:MGI:1919090
    See related
    Ensembl:ENSMUSG00000024175 AllianceGenome:MGI:1919090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700010L19Rik
    Summary
    Involved in flagellated sperm motility. Acts upstream of with a positive effect on regulation of brood size. Acts upstream of or within cilium movement involved in cell motility. Located in sperm midpiece and sperm principal piece. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in choroid invagination; diencephalon roof plate; and metencephalon part of 4th ventricle choroid plexus. Orthologous to human TEKT4 (tektin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 138.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tekt4 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.6 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25673511..25695576)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25454549..25476602)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tryptase gamma 1 Neighboring gene calcium channel, voltage-dependent, T type, alpha 1H subunit Neighboring gene predicted gene, 33617 Neighboring gene STARR-seq mESC enhancer starr_42107 Neighboring gene somatostatin receptor 5 Neighboring gene predicted gene, 53993 Neighboring gene predicted gene, 33727

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC144759, MGC144760

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cilium movement involved in cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_positive_effect regulation of brood size IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tektin-4
    Names
    testicular microtubules-related protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418821.1NP_001405750.1  tektin-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131323
      UniProtKB/TrEMBL
      A0A3Q4EH78
      Related
      ENSMUSP00000157356.2, ENSMUST00000235033.3
    2. NM_001418822.1NP_001405751.1  tektin-4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131323
      UniProtKB/TrEMBL
      A0AAA9WUT0
      Related
      ENSMUSP00000159923.1, ENSMUST00000249765.1
    3. NM_027951.2NP_082227.1  tektin-4 isoform 1

      See identical proteins and their annotated locations for NP_082227.1

      Status: VALIDATED

      Source sequence(s)
      AC131323
      Consensus CDS
      CCDS28519.1
      UniProtKB/Swiss-Prot
      A0A0R4J051, Q149S1, Q3ZTL6, Q9DAH3
      Related
      ENSMUSP00000025002.2, ENSMUST00000025002.4
      Conserved Domains (1) summary
      pfam03148
      Location:56434
      Tektin; Tektin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25673511..25695576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524948.3XP_006525011.1  tektin-4 isoform X1

      Conserved Domains (1) summary
      pfam03148
      Location:46305
      Tektin; Tektin family