U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Clasp2 cytoplasmic linker associated protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114514, updated on 3-Dec-2024

    Summary

    Official Symbol
    Clasp2provided by RGD
    Official Full Name
    cytoplasmic linker associated protein 2provided by RGD
    Primary source
    RGD:619789
    See related
    EnsemblRapid:ENSRNOG00000009161 AllianceGenome:RGD:619789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables microtubule binding activity. Involved in cellular response to insulin stimulus; negative regulation of microtubule depolymerization; and positive regulation of protein localization to membrane. Located in microtubule and ruffle membrane. Orthologous to human CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 402.6), Adrenal (RPKM 146.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Clasp2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (122555532..122736934)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (113677345..113859957)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (122003719..122185495)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene programmed cell death 6 interacting protein Neighboring gene uncharacterized LOC100910424 Neighboring gene uncharacterized LOC134480240 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120094275 Neighboring gene upstream binding protein 1 Neighboring gene F-box and leucine-rich repeat protein 2 Neighboring gene COP9 signalosome subunit 7B, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dystroglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule plus-end binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in exit from mitosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in exit from mitosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule anchoring ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule anchoring ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule organizing center organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule organizing center organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of supramolecular fiber organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in presynaptic cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gastrulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of microtubule polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule-based process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of supramolecular fiber organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle targeting ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in basal cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basal cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053722.2NP_446174.1  CLIP-associating protein 2

      See identical proteins and their annotated locations for NP_446174.1

      Status: VALIDATED

      Source sequence(s)
      AJ288060, CX570719, DY568613
      UniProtKB/Swiss-Prot
      Q99JD4
      UniProtKB/TrEMBL
      A0A8I6GL90, A6I3M4
      Related
      ENSRNOP00000095678.2, ENSRNOT00000100370.2
      Conserved Domains (2) summary
      sd00044
      Location:648675
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:99311
      CLASP_N; CLASP N terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      122555532..122736934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264756.1XP_063120826.1  CLIP-associating protein 2 isoform X32

      UniProtKB/TrEMBL
      A0A8I5ZX03, A0A8I6AMK8
      Related
      ENSRNOP00000095411.2, ENSRNOT00000111450.2
    2. XM_063264733.1XP_063120803.1  CLIP-associating protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    3. XM_039080674.2XP_038936602.1  CLIP-associating protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZKF9
      Conserved Domains (3) summary
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:687809
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam12348
      Location:326538
      CLASP_N; CLASP N terminal
    4. XM_063264735.1XP_063120805.1  CLIP-associating protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    5. XM_039080677.2XP_038936605.1  CLIP-associating protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZKF9
      Conserved Domains (3) summary
      PHA03307
      Location:570824
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326538
      CLASP_N; CLASP N terminal
    6. XM_063264739.1XP_063120809.1  CLIP-associating protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    7. XM_063264745.1XP_063120815.1  CLIP-associating protein 2 isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    8. XM_063264743.1XP_063120813.1  CLIP-associating protein 2 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZX03
    9. XM_063264747.1XP_063120817.1  CLIP-associating protein 2 isoform X19

      UniProtKB/TrEMBL
      A0A8I5ZX03
    10. XM_063264750.1XP_063120820.1  CLIP-associating protein 2 isoform X24

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    11. XM_063264752.1XP_063120822.1  CLIP-associating protein 2 isoform X27

      UniProtKB/TrEMBL
      A0A8I5ZKF9, A0A8I5ZX03
    12. XM_063264736.1XP_063120806.1  CLIP-associating protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    13. XM_063264741.1XP_063120811.1  CLIP-associating protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    14. XM_063264748.1XP_063120818.1  CLIP-associating protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    15. XM_039080685.2XP_038936613.1  CLIP-associating protein 2 isoform X22

      UniProtKB/TrEMBL
      A0A8I5ZX03
      Related
      ENSRNOP00000012545.6, ENSRNOT00000012545.6
      Conserved Domains (2) summary
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326538
      CLASP_N; CLASP N terminal
    16. XM_063264738.1XP_063120808.1  CLIP-associating protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    17. XM_039080680.2XP_038936608.1  CLIP-associating protein 2 isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZKF9
      Related
      ENSRNOP00000078073.2, ENSRNOT00000117265.2
      Conserved Domains (2) summary
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326538
      CLASP_N; CLASP N terminal
    18. XM_063264742.1XP_063120812.1  CLIP-associating protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    19. XM_039080683.2XP_038936611.1  CLIP-associating protein 2 isoform X18

      UniProtKB/TrEMBL
      A0A8I5ZKF9
      Conserved Domains (2) summary
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326538
      CLASP_N; CLASP N terminal
    20. XM_063264746.1XP_063120816.1  CLIP-associating protein 2 isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    21. XM_039080686.2XP_038936614.1  CLIP-associating protein 2 isoform X23

      UniProtKB/TrEMBL
      A0A8I5ZKF9
      Related
      ENSRNOP00000071109.3, ENSRNOT00000091980.3
      Conserved Domains (2) summary
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326538
      CLASP_N; CLASP N terminal
    22. XM_063264749.1XP_063120819.1  CLIP-associating protein 2 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZX03
    23. XM_039080688.2XP_038936616.1  CLIP-associating protein 2 isoform X26

      UniProtKB/TrEMBL
      A0A8I5ZX03
      Conserved Domains (2) summary
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326538
      CLASP_N; CLASP N terminal
    24. XM_063264754.1XP_063120824.1  CLIP-associating protein 2 isoform X29

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    25. XM_063264734.1XP_063120804.1  CLIP-associating protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    26. XM_063264740.1XP_063120810.1  CLIP-associating protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    27. XM_063264753.1XP_063120823.1  CLIP-associating protein 2 isoform X28

      UniProtKB/TrEMBL
      A0A8I5ZX03
    28. XM_063264737.1XP_063120807.1  CLIP-associating protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    29. XM_063264744.1XP_063120814.1  CLIP-associating protein 2 isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    30. XM_063264771.1XP_063120841.1  CLIP-associating protein 2 isoform X49

      UniProtKB/TrEMBL
      A0A8I5ZKF9, A0A8I6AMJ1
      Related
      ENSRNOP00000095387.1, ENSRNOT00000113161.2
    31. XM_063264751.1XP_063120821.1  CLIP-associating protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A8I5ZX03
    32. XM_039080691.2XP_038936619.1  CLIP-associating protein 2 isoform X30

      UniProtKB/TrEMBL
      A0A8I5ZX03
      Related
      ENSRNOP00000083968.1, ENSRNOT00000107377.2
      Conserved Domains (2) summary
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326538
      CLASP_N; CLASP N terminal
    33. XM_063264755.1XP_063120825.1  CLIP-associating protein 2 isoform X31

      UniProtKB/TrEMBL
      A0A8I5ZKF9
    34. XM_063264758.1XP_063120828.1  CLIP-associating protein 2 isoform X34

      UniProtKB/TrEMBL
      A0A8I5YBJ9
    35. XM_063264761.1XP_063120831.1  CLIP-associating protein 2 isoform X37

      UniProtKB/TrEMBL
      A0A8I5YBJ9
    36. XM_063264764.1XP_063120834.1  CLIP-associating protein 2 isoform X41

      UniProtKB/TrEMBL
      A0A8I5YBJ9
    37. XM_063264768.1XP_063120838.1  CLIP-associating protein 2 isoform X45

      UniProtKB/TrEMBL
      A0A8I5YBJ9
    38. XM_063264769.1XP_063120839.1  CLIP-associating protein 2 isoform X47

      UniProtKB/TrEMBL
      A0A8I5YBJ9
    39. XM_063264770.1XP_063120840.1  CLIP-associating protein 2 isoform X48

      UniProtKB/TrEMBL
      A0A8I5YBJ9
    40. XM_063264762.1XP_063120832.1  CLIP-associating protein 2 isoform X38

      UniProtKB/TrEMBL
      A0A8I6GL90
    41. XM_063264757.1XP_063120827.1  CLIP-associating protein 2 isoform X33

      UniProtKB/TrEMBL
      A0A8I6GL90
    42. XM_063264759.1XP_063120829.1  CLIP-associating protein 2 isoform X35

      UniProtKB/TrEMBL
      A0A8I6GL90
    43. XM_017595407.3XP_017450896.1  CLIP-associating protein 2 isoform X39

      UniProtKB/TrEMBL
      A0A8I6GL90, A0A8L2UIH1
    44. XM_063264766.1XP_063120836.1  CLIP-associating protein 2 isoform X43

      UniProtKB/TrEMBL
      A0A8I6GL90
    45. XM_063264767.1XP_063120837.1  CLIP-associating protein 2 isoform X44

      UniProtKB/TrEMBL
      A0A8I6GL90
    46. XM_063264760.1XP_063120830.1  CLIP-associating protein 2 isoform X36

      UniProtKB/TrEMBL
      A0A8I6GL90
    47. XM_063264763.1XP_063120833.1  CLIP-associating protein 2 isoform X40

      UniProtKB/TrEMBL
      A0A8I6GL90
    48. XM_063264765.1XP_063120835.1  CLIP-associating protein 2 isoform X42

      UniProtKB/TrEMBL
      A0A8I6GL90
    49. XM_039080695.2XP_038936623.1  CLIP-associating protein 2 isoform X46

      UniProtKB/TrEMBL
      A0A8I6GL90
      Conserved Domains (2) summary
      sd00044
      Location:640667
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:99311
      CLASP_N; CLASP N terminal