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    Tpsb2 tryptase beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 17229, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tpsb2provided by MGI
    Official Full Name
    tryptase beta 2provided by MGI
    Primary source
    MGI:MGI:96942
    See related
    Ensembl:ENSMUSG00000033825 AllianceGenome:MGI:96942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mcp6; Mcp-6; Mcpt6; MMCP-6
    Summary
    Enables heparin binding activity and peptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within inflammatory response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; immune system; lumbar vertebra; and skin. Orthologous to several human genes including TPSAB1 (tryptase alpha/beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 46.5), stomach adult (RPKM 13.0) and 6 other tissues See more
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    Genomic context

    See Tpsb2 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25585282..25587070)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25366308..25368096)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene tryptase alpha/beta 1 Neighboring gene STARR-seq mESC enhancer starr_42106 Neighboring gene tryptase gamma 1 Neighboring gene calcium channel, voltage-dependent, T type, alpha 1H subunit Neighboring gene predicted gene, 33617

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    tryptase beta-2
    Names
    mast cell protease 6
    tryptase-2
    NP_034911.3
    XP_006523803.1
    XP_030105385.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010781.3NP_034911.3  tryptase beta-2 precursor

      See identical proteins and their annotated locations for NP_034911.3

      Status: VALIDATED

      Source sequence(s)
      AC122454
      Consensus CDS
      CCDS28517.1
      UniProtKB/Swiss-Prot
      P21845, Q61962
      UniProtKB/TrEMBL
      B5A5B2, E9QJW9
      Related
      ENSMUSP00000157286.2, ENSMUST00000234477.3
      Conserved Domains (1) summary
      cd00190
      Location:32270
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25585282..25587070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523740.3XP_006523803.1  tryptase beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006523803.1

      UniProtKB/Swiss-Prot
      P21845, Q61962
      UniProtKB/TrEMBL
      B5A5B2, E9QJW9
      Related
      ENSMUSP00000159899.1, ENSMUST00000249732.1
      Conserved Domains (1) summary
      cd00190
      Location:32270
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_030249525.1XP_030105385.1  tryptase beta-2 isoform X2

      Conserved Domains (1) summary
      cd00190
      Location:15202
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...