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    Nectin4 nectin cell adhesion molecule 4 [ Mus musculus (house mouse) ]

    Gene ID: 71740, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nectin4provided by MGI
    Official Full Name
    nectin cell adhesion molecule 4provided by MGI
    Primary source
    MGI:MGI:1918990
    See related
    Ensembl:ENSMUSG00000006411 AllianceGenome:MGI:1918990
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prr4; Pvrl4; 1200017F15Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in plasma membrane. Predicted to be active in adherens junction. Is expressed in several structures, including alimentary system; genitourinary system; nose; respiratory system; and skin. Orthologous to human NECTIN4 (nectin cell adhesion molecule 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 13.9), genital fat pad adult (RPKM 9.3) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nectin4 in Genome Data Viewer
    Location:
    1 H3; 1 79.37 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171197741..171215855)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171370173..171388287)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene death effector domain-containing Neighboring gene STARR-positive B cell enhancer ABC_E2019 Neighboring gene nitrilase 1 Neighboring gene prefoldin 2 Neighboring gene STARR-positive B cell enhancer ABC_E4387 Neighboring gene kelch domain containing 9 Neighboring gene STARR-positive B cell enhancer ABC_E4388 Neighboring gene Rho GTPase activating protein 30 Neighboring gene STARR-positive B cell enhancer ABC_E4389 Neighboring gene STARR-positive B cell enhancer ABC_E799 Neighboring gene STARR-positive B cell enhancer ABC_E10057 Neighboring gene upstream transcription factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nectin-4
    Names
    ig superfamily receptor LNIR
    nectin 4
    poliovirus receptor-related 4
    poliovirus receptor-related protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122680.1NP_001116152.1  nectin-4 isoform b precursor

      See identical proteins and their annotated locations for NP_001116152.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.
      Source sequence(s)
      AK004821, AK028479, BX638135, BY154786
      Consensus CDS
      CCDS48442.1
      UniProtKB/Swiss-Prot
      Q8R007
      Related
      ENSMUSP00000091883.5, ENSMUST00000094325.5
      Conserved Domains (4) summary
      cd00096
      Location:265328
      Ig; Immunoglobulin domain
      cd07704
      Location:148241
      Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
      smart00410
      Location:258331
      IG_like; Immunoglobulin like
      cl11960
      Location:45145
      Ig; Immunoglobulin domain
    2. NM_027893.3NP_082169.2  nectin-4 isoform a precursor

      See identical proteins and their annotated locations for NP_082169.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
      Source sequence(s)
      AK004821, AK028479, BX638135, BY154786
      Consensus CDS
      CCDS15493.1
      UniProtKB/Swiss-Prot
      Q3U318, Q8CED8, Q8R007, Q9DBP8
      Related
      ENSMUSP00000006578.4, ENSMUST00000006578.10
      Conserved Domains (4) summary
      cd00096
      Location:265328
      Ig; Immunoglobulin domain
      cd07704
      Location:148241
      Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
      smart00410
      Location:258331
      IG_like; Immunoglobulin like
      cl11960
      Location:45145
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171197741..171215855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)