Fbxw7 F-box and WD-40 domain protein 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxw7provided by MGI
Official Full Name: F-box and WD-40 domain protein 7provided by MGI
Primary source: MGI:MGI:1354695
See related: Ensembl:ENSMUSG00000028086 AllianceGenome:MGI:1354695
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AGO; Cdc4; Fbw7; Fbwd6; Fbx30; Fbxw6; Fbxo30; SEL-10; 1110001A17Rik
Summary: Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of osteoclast development; and positive regulation of proteolysis involved in protein catabolic process. Acts upstream of or within several processes, including Notch signaling pathway; protein destabilization; and vasculogenesis. Located in several cellular components, including Golgi apparatus; nucleolus; and perinuclear region of cytoplasm. Is expressed in central nervous system; early conceptus; genitourinary system; and skeletal muscle tissue. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cortex adult (RPKM 16.6), frontal lobe adult (RPKM 13.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 37.7 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (84721901..84886505)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (84814990..84979198)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Fbxw7 in oocytes causes follicle loss and premature ovarian insufficiency in mice.
Title: Deletion of Fbxw7 in oocytes causes follicle loss and premature ovarian insufficiency in mice.
Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo.
Title: Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo.
FBW7/GSK3beta mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.
Title: FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.
Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic Cells Is Critical for Psoriasis-like Inflammation.
Title: Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic Cells Is Critical for Psoriasis-like Inflammation.
Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male mice.
Title: Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male mice.
High-fat diet aggravates the severity of the in vitro posttraumatic osteoarthritis model through macrophagic FBW7.
Title: High-fat diet aggravates the severity of the in vitro posttraumatic osteoarthritis model through macrophagic FBW7.
FBXW7 Enhances Cisplatin-Induced Apoptosis in Oral Cancer Cell Lines.
Title: FBXW7 Enhances Cisplatin-Induced Apoptosis in Oral Cancer Cell Lines.
MiR-223-3p regulates the eosinophil degranulation and enhances the inflammation in allergic rhinitis by targeting FBXW7.
Title: MiR-223-3p regulates the eosinophil degranulation and enhances the inflammation in allergic rhinitis by targeting FBXW7.
FBXW7 inactivation induces cellular senescence via accumulation of p53.
Title: FBXW7 inactivation induces cellular senescence via accumulation of p53.
E3 Ligase FBXW7 Facilitates Mycobacterium Immune Evasion by Modulating TNF-alpha Expression.
Title: E3 Ligase FBXW7 Facilitates Mycobacterium Immune Evasion by Modulating TNF-α Expression.

Submit: New GeneRIF Correction See all GeneRIFs (107)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (14) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

13.mHAa9g1.seq (e-PCR)
- UniSTS:123191

Fbxw7 (e-PCR), detects polymorphism
- UniSTS:498235

RH136531 (e-PCR)
- UniSTS:210513

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables cyclin binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphothreonine residue binding	ISO Inferred from Sequence Orthology more info
enables phosphothreonine residue binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoclast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of osteoclast development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epidermal growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor-activated receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein destabilization	IDA Inferred from Direct Assay more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein ubiquitination	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin recycling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box/WD repeat-containing protein 7

Names: F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; F-box-WD40 repeat protein 6; f-box only protein 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177773.2 → NP_001171244.1 F-box/WD repeat-containing protein 7 isoform 1

See identical proteins and their annotated locations for NP_001171244.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, as compared to variant 1. Both variants 1 and 2 encode the same isoform 1.

Source sequence(s)

AC124496, AC158583

Consensus CDS

CCDS50940.1

UniProtKB/Swiss-Prot

A2RRI5, D3YUA5, Q8CCS5, Q8VBV4, Q8VHP4

Related

ENSMUSP00000103306.2, ENSMUST00000107679.8

Conserved Domains (3) summary

cd00200
Location:377 → 653

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:387 → 422

7WD40; WD40 repeat [structural motif]

pfam12937
Location:284 → 328

F-box-like
NM_001177774.2 → NP_001171245.1 F-box/WD repeat-containing protein 7 isoform 1

See identical proteins and their annotated locations for NP_001171245.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).

Source sequence(s)

AC124496, AC158583

Consensus CDS

CCDS50940.1

UniProtKB/Swiss-Prot

A2RRI5, D3YUA5, Q8CCS5, Q8VBV4, Q8VHP4

Related

ENSMUSP00000103305.2, ENSMUST00000107678.8

Conserved Domains (3) summary

cd00200
Location:377 → 653

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:387 → 422

7WD40; WD40 repeat [structural motif]

pfam12937
Location:284 → 328

F-box-like
NM_001428748.1 → NP_001415677.1 F-box/WD repeat-containing protein 7 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks four 5' exons, but has an alternate 5' exon including coding region, as compared to variant 1. The resulting isoform (3) is shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

AC124496, AC158583

UniProtKB/TrEMBL

D3YUA8
NM_080428.4 → NP_536353.2 F-box/WD repeat-containing protein 7 isoform 2

See identical proteins and their annotated locations for NP_536353.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks four 5' exons, but has an alternate 5' exon including coding region, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

AC124496, AC158583

Consensus CDS

CCDS17440.1

UniProtKB/Swiss-Prot

Q8VBV4

Related

ENSMUSP00000029727.8, ENSMUST00000029727.8

Conserved Domains (3) summary

cd00200
Location:296 → 572

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:306 → 341

7WD40; WD40 repeat [structural motif]

pfam12937
Location:203 → 247

F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

84721901..84886505

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501657.5 → XP_006501720.1 F-box/WD repeat-containing protein 7 isoform X1

See identical proteins and their annotated locations for XP_006501720.1

UniProtKB/Swiss-Prot

A2RRI5, D3YUA5, Q8CCS5, Q8VBV4, Q8VHP4

Conserved Domains (3) summary

cd00200
Location:377 → 653

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:387 → 422

7WD40; WD40 repeat [structural motif]

pfam12937
Location:284 → 328

F-box-like
XM_006501656.4 → XP_006501719.1 F-box/WD repeat-containing protein 7 isoform X1

Conserved Domains (3) summary

cd00200
Location:377 → 653

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:387 → 422

7WD40; WD40 repeat [structural motif]

pfam12937
Location:284 → 328

F-box-like
XM_006501658.4 → XP_006501721.1 F-box/WD repeat-containing protein 7 isoform X2

Related

ENSMUSP00000103302.2, ENSMUST00000107675.8

Conserved Domains (3) summary

cd00200
Location:256 → 532

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:266 → 301

7WD40; WD40 repeat [structural motif]

pfam12937
Location:163 → 207

F-box-like