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    Phkg2 phosphorylase kinase catalytic subunit gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140671, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Phkg2provided by RGD
    Official Full Name
    phosphorylase kinase catalytic subunit gamma 2provided by RGD
    Primary source
    RGD:620024
    See related
    EnsemblRapid:ENSRNOG00000018725 AllianceGenome:RGD:620024
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including ATP binding activity; calmodulin binding activity; and phosphorylase kinase activity. Involved in glycogen metabolic process; positive regulation of glycogen catabolic process; and protein phosphorylation. Part of phosphorylase kinase complex. Used to study glycogen storage disease. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease IXc; and liver cirrhosis. Orthologous to human PHKG2 (phosphorylase kinase catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 429.0), Thymus (RPKM 117.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Phkg2 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191614738..191627615)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182184362..182197124)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199019298..199032053)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Snf2-related CREBBP activator protein Neighboring gene small nucleolar RNA, H/ACA box 30 Neighboring gene transmembrane protein 265 Neighboring gene cilia and flagella associated protein 119 Neighboring gene ring finger protein 40 Neighboring gene zinc finger protein 629 Neighboring gene 5S ribosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glycogenolysis in liver of phosphorylase kinase-deficient rats during liver perfusion and ischaemia. Lutaya G, et al. Biochem J, 1983 Aug 15. PMID 6615485, Free PMC Article
    2. Molecular cloning and enzymatic analysis of the rat homolog of "PhK-gamma T," an isoform of phosphorylase kinase catalytic subunit. Calalb MB, et al. J Biol Chem, 1992 Jan 25. PMID 1370475
    3. Liver glycogenosis due to phosphorylase kinase deficiency: PHKG2 gene structure and mutations associated with cirrhosis. Burwinkel B, et al. Hum Mol Genet, 1998 Jan. PMID 9384616
    4. Mutations in the testis/liver isoform of the phosphorylase kinase gamma subunit (PHKG2) cause autosomal liver glycogenosis in the gsd rat and in humans. Maichele AJ, et al. Nat Genet, 1996 Nov. PMID 8896567
    5. Comparison of glycogen phosphorylase kinases of various rat tissues. Taira T, et al. J Biochem, 1982 Mar. PMID 6281247

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorylase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorylase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorylase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phosphorylase kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphorylase kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphorylase b kinase gamma catalytic chain, liver/testis isoform
    Names
    PHK-gamma-LT
    PHK-gamma-T
    phosphorylase kinase gamma subunit 2
    phosphorylase kinase subunit gamma-2
    phosphorylase kinase, gamma 2 (testis)
    serine/threonine-protein kinase PHKG2
    NP_542151.1
    XP_008758077.1
    XP_038937387.1
    XP_038937457.1
    XP_038937492.1
    XP_038937593.1
    XP_063126562.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080584.4 → NP_542151.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform

      See identical proteins and their annotated locations for NP_542151.1

      Status: PROVISIONAL

      Source sequence(s)
      M73808
      UniProtKB/Swiss-Prot
      A1A5L8, P31325
      UniProtKB/TrEMBL
      A6I9R0
      Conserved Domains (1) summary
      cd14181
      Location:13 → 291
      STKc_PhKG2; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191614738..191627615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270492.1 → XP_063126562.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

      UniProtKB/Swiss-Prot
      A1A5L8, P31325

    2. XM_008759855.4 → XP_008758077.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

      See identical proteins and their annotated locations for XP_008758077.1

      UniProtKB/Swiss-Prot
      A1A5L8, P31325
      UniProtKB/TrEMBL
      A6I9R0
      Conserved Domains (1) summary
      cd14181
      Location:13 → 291
      STKc_PhKG2; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit

    3. XM_039081459.2 → XP_038937387.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

      UniProtKB/Swiss-Prot
      A1A5L8, P31325
      UniProtKB/TrEMBL
      A6I9R0
      Related
      ENSRNOP00000072734.1, ENSRNOT00000087142.3
      Conserved Domains (1) summary
      cd14181
      Location:13 → 291
      STKc_PhKG2; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit

    4. XM_039081665.2 → XP_038937593.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:13 → 267
      PKc_like; Protein Kinases, catalytic domain

    5. XM_039081529.2 → XP_038937457.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

      UniProtKB/Swiss-Prot
      A1A5L8, P31325
      UniProtKB/TrEMBL
      A6I9R0
      Conserved Domains (1) summary
      cd14181
      Location:13 → 291
      STKc_PhKG2; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit

    6. XM_039081564.2 → XP_038937492.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X2

      UniProtKB/TrEMBL
      A6I9R1, A6I9R4
      Conserved Domains (1) summary
      cl21453
      Location:1 → 189
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31325.1 GenPept UniProtKB/Swiss-Prot:P31325

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