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    Pde1a phosphodiesterase 1A, calmodulin-dependent [ Mus musculus (house mouse) ]

    Gene ID: 18573, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pde1aprovided by MGI
    Official Full Name
    phosphodiesterase 1A, calmodulin-dependentprovided by MGI
    Primary source
    MGI:MGI:1201792
    See related
    Ensembl:ENSMUSG00000059173 AllianceGenome:MGI:1201792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity and calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in several processes, including cAMP-mediated signaling; cGMP catabolic process; and regulation of smooth muscle cell apoptotic process. Located in sperm flagellum. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PDE1A (phosphodiesterase 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 19.1), frontal lobe adult (RPKM 12.1) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pde1a in Genome Data Viewer
    Location:
    2 C3; 2 47.64 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (79664797..80026862, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (79834453..80196522, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2625 Neighboring gene ITPR interacting domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_04937 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 1C Neighboring gene STARR-seq mESC enhancer starr_04938 Neighboring gene STARR-seq mESC enhancer starr_04939 Neighboring gene predicted gene, 54166 Neighboring gene STARR-seq mESC enhancer starr_04941 Neighboring gene STARR-seq mESC enhancer starr_04942 Neighboring gene STARR-seq mESC enhancer starr_04943 Neighboring gene predicted gene 13674 Neighboring gene STARR-positive B cell enhancer ABC_E5939 Neighboring gene predicted gene, 36153 Neighboring gene peroxiredoxin 6B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC116577

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cGMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cGMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of smooth muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
    Names
    61 kDa Cam-PDE
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
    cam-PDE 1A
    NP_001009978.1
    NP_001009979.1
    NP_001153054.1
    NP_001342069.1
    NP_001342070.1
    NP_001342071.1
    NP_001342073.1
    NP_001407456.1
    NP_001407458.1
    NP_058024.2
    XP_006498982.1
    XP_030104296.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009978.2NP_001009978.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7

      See identical proteins and their annotated locations for NP_001009978.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' and 3' ends (UTR and coding sequence) compared to variant 1. The resulting isoform (7) has shorter and distinct N- and C-termini compared to isoform 2.
      Source sequence(s)
      AL928607
      Consensus CDS
      CCDS16173.1
      UniProtKB/TrEMBL
      F6X0V1
      Related
      ENSMUSP00000099712.4, ENSMUST00000102652.10
      Conserved Domains (2) summary
      pfam00233
      Location:150366
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:965
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    2. NM_001009979.2NP_001009979.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9

      See identical proteins and their annotated locations for NP_001009979.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' and 3' ends (UTR and coding sequence) compared to variant 1. The resulting isoform (9) has shorter and distinct N- and C-termini compared to isoform 2.
      Source sequence(s)
      AL928607
      Consensus CDS
      CCDS16174.1
      UniProtKB/TrEMBL
      F6X0V1
      Related
      ENSMUSP00000099711.4, ENSMUST00000102651.10
      Conserved Domains (2) summary
      pfam00233
      Location:150366
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:965
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    3. NM_001159582.2NP_001153054.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

      See identical proteins and their annotated locations for NP_001153054.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (2). Variants 1, 2, 10, and 11 all encode isoform 2.
      Source sequence(s)
      AL844577, AL928607, AL928811
      Consensus CDS
      CCDS16172.1
      UniProtKB/Swiss-Prot
      E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
      UniProtKB/TrEMBL
      F6X0V1
      Related
      ENSMUSP00000099713.2, ENSMUST00000102653.8
      Conserved Domains (2) summary
      pfam00233
      Location:218434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    4. NM_001355140.2NP_001342069.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 2, and 11, encodes isoform 2.
      Source sequence(s)
      AL844577, AL928607, AL928811
      Consensus CDS
      CCDS16172.1
      UniProtKB/Swiss-Prot
      E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
      UniProtKB/TrEMBL
      F6X0V1
      Conserved Domains (2) summary
      pfam00233
      Location:218434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    5. NM_001355141.2NP_001342070.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 1, 2, and 10, encodes isoform 2.
      Source sequence(s)
      AL844577, AL928607, AL928811
      Consensus CDS
      CCDS16172.1
      UniProtKB/Swiss-Prot
      E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
      UniProtKB/TrEMBL
      F6X0V1
      Conserved Domains (2) summary
      pfam00233
      Location:218434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    6. NM_001355142.2NP_001342071.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL844577, AL928607, AL928811
      UniProtKB/TrEMBL
      F6X0V1
      Related
      ENSMUSP00000160024.1, ENSMUST00000146076.9
      Conserved Domains (2) summary
      pfam00233
      Location:202418
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    7. NM_001355144.2NP_001342073.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL928607
      Consensus CDS
      CCDS89501.1
      UniProtKB/TrEMBL
      A2ASF9, F6X0V1
      Related
      ENSMUSP00000088260.5, ENSMUST00000090756.11
      Conserved Domains (2) summary
      pfam00233
      Location:114330
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:1429
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    8. NM_001420527.1NP_001407456.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL928607, AL928811
      UniProtKB/TrEMBL
      F6X0V1
    9. NM_001420529.1NP_001407458.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL928607, AL928811
      UniProtKB/TrEMBL
      F6X0V1
      Related
      ENSMUSP00000120188.2, ENSMUST00000134739.2
    10. NM_016744.5NP_058024.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

      See identical proteins and their annotated locations for NP_058024.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 10, and 11 all encode isoform 2.
      Source sequence(s)
      AL844577, AL928607, AL928811
      Consensus CDS
      CCDS16172.1
      UniProtKB/Swiss-Prot
      E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
      UniProtKB/TrEMBL
      F6X0V1
      Related
      ENSMUSP00000099715.4, ENSMUST00000102655.10
      Conserved Domains (2) summary
      pfam00233
      Location:218434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      79664797..80026862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498919.4XP_006498982.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1

      See identical proteins and their annotated locations for XP_006498982.1

      UniProtKB/Swiss-Prot
      E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
      UniProtKB/TrEMBL
      F6X0V1
      Conserved Domains (2) summary
      pfam00233
      Location:218434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    2. XM_030248436.2XP_030104296.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3

      UniProtKB/TrEMBL
      F6X0V1
      Conserved Domains (2) summary
      pfam00233
      Location:202418
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001355143.1: Suppressed sequence

      Description
      NM_001355143.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.