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    Parp16 poly (ADP-ribose) polymerase family, member 16 [ Mus musculus (house mouse) ]

    Gene ID: 214424, updated on 9-Dec-2024

    Summary

    Official Symbol
    Parp16provided by MGI
    Official Full Name
    poly (ADP-ribose) polymerase family, member 16provided by MGI
    Primary source
    MGI:MGI:2446133
    See related
    Ensembl:ENSMUSG00000032392 AllianceGenome:MGI:2446133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARTD15; PARP-16
    Summary
    Predicted to enable NAD+-protein ADP-ribosyltransferase activity; kinase binding activity; and protein serine/threonine kinase activator activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system. Orthologous to human PARP16 (poly(ADP-ribose) polymerase family member 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 11.5), ovary adult (RPKM 5.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Parp16 in Genome Data Viewer
    Location:
    9 C; 9 35.17 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65121918..65146502)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65214652..65239220)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3840 Neighboring gene STARR-positive B cell enhancer ABC_E2894 Neighboring gene predicted gene, 40527 Neighboring gene predicted gene, 25313 Neighboring gene RNA, U5G small nuclear Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65064991-65065144 Neighboring gene predicted gene, 36538 Neighboring gene STARR-seq mESC enhancer starr_24450 Neighboring gene cartilage intermediate layer protein, nucleotide pyrophosphohydrolase Neighboring gene STARR-positive B cell enhancer ABC_E5079 Neighboring gene predicted gene 16218 Neighboring gene caseinolytic mitochondrial matrix peptidase chaperone subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC65335

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+-protein ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD+-protein ADP-ribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+-protein poly-ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD+-protein-aspartate ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD+-protein-aspartate ADP-ribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD+-protein-glutamate ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD+-protein-glutamate ADP-ribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD+-protein-lysine ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD+-protein-lysine ADP-ribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum tubular network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein mono-ADP-ribosyltransferase PARP16
    Names
    ADP-ribosyltransferase diphtheria toxin-like 15
    mono [ADP-ribose] polymerase PARP16
    poly [ADP-ribose] polymerase 16
    NP_803411.3
    XP_011241004.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177460.4NP_803411.3  protein mono-ADP-ribosyltransferase PARP16

      See identical proteins and their annotated locations for NP_803411.3

      Status: VALIDATED

      Source sequence(s)
      AK133475, BY430063
      Consensus CDS
      CCDS23286.1
      UniProtKB/Swiss-Prot
      Q3V031, Q7TMM8, Q8CC71
      Related
      ENSMUSP00000070098.8, ENSMUST00000069000.9
      Conserved Domains (2) summary
      pfam00644
      Location:95273
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl00283
      Location:150203
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      65121918..65146502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242702.3XP_011241004.1  protein mono-ADP-ribosyltransferase PARP16 isoform X1

      Conserved Domains (2) summary
      pfam00644
      Location:108204
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam18084
      Location:1690
      ARTD15_N; ARTD15 N-terminal domain

    RNA

    1. XR_870755.4 RNA Sequence

    2. XR_001778840.2 RNA Sequence

    3. XR_003947837.1 RNA Sequence