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    Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 [ Mus musculus (house mouse) ]

    Gene ID: 75406, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ndufs7provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit S7provided by MGI
    Primary source
    MGI:MGI:1922656
    See related
    Ensembl:ENSMUSG00000020153 AllianceGenome:MGI:1922656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CI-20kD; 1010001M04Rik
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity and protease binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in electron transport coupled proton transport; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; integumental system; respiratory system; retina; and urinary system. Human ortholog(s) of this gene implicated in developmental disorder of mental health and nuclear type mitochondrial complex I deficiency 3. Orthologous to human NDUFS7 (NADH:ubiquinone oxidoreductase core subunit S7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 322.2), duodenum adult (RPKM 296.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    Location:
    10 C1; 10 39.72 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80084939..80092628)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80249105..80256794)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3898 Neighboring gene PWWP domain containing 3A, DNA repair factor Neighboring gene nuclear encoded tRNA pheylalanine 3 (anticodon GAA) Neighboring gene nuclear encoded tRNA asparagine 7 (anticodon GTT) Neighboring gene STARR-positive B cell enhancer ABC_E5153 Neighboring gene STARR-positive B cell enhancer ABC_E10627 Neighboring gene guanidinoacetate methyltransferase Neighboring gene DAZ associated protein 1 Neighboring gene microRNA 6911

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NADH dehydrogenase (ubiquinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADH dehydrogenase (ubiquinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to NADH dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to NADH dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in electron transport coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial electron transport, NADH to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
     
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) Fe-S protein 7
    NADH-ubiquinone oxidoreductase 20 kDa subunit
    complex I-20kD
    NP_001351623.1
    NP_083548.1
    XP_006514333.1
    XP_030101204.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364694.1NP_001351623.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC140229
      Conserved Domains (1) summary
      PRK06411
      Location:74192
      PRK06411; NADH dehydrogenase subunit B; Validated
    2. NM_029272.4NP_083548.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_083548.1

      Status: VALIDATED

      Source sequence(s)
      AC140229
      Consensus CDS
      CCDS24015.1
      UniProtKB/Swiss-Prot
      Q9DC70
      Related
      ENSMUSP00000020361.7, ENSMUST00000020361.7
      Conserved Domains (1) summary
      PRK06411
      Location:74224
      PRK06411; NADH-quinone oxidoreductase subunit NuoB

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80084939..80092628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514270.2XP_006514333.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2

      Conserved Domains (1) summary
      PRK06411
      Location:46196
      PRK06411; NADH-quinone oxidoreductase subunit NuoB
    2. XM_030245344.2XP_030101204.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q9DC70
      Related
      ENSMUSP00000101003.2, ENSMUST00000105364.8
      Conserved Domains (1) summary
      PRK06411
      Location:74224
      PRK06411; NADH-quinone oxidoreductase subunit NuoB