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    C3ar1 complement component 3a receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 12267, updated on 9-Dec-2024

    Summary

    Official Symbol
    C3ar1provided by MGI
    Official Full Name
    complement component 3a receptor 1provided by MGI
    Primary source
    MGI:MGI:1097680
    See related
    Ensembl:ENSMUSG00000040552 AllianceGenome:MGI:1097680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AZ3B; C3AR; HNFAG09
    Summary
    Predicted to enable G protein-coupled receptor activity; complement component C3a binding activity; and complement receptor activity. Involved in positive regulation of angiogenesis; positive regulation of vascular endothelial growth factor production; and regulation of granulocyte chemotaxis. Predicted to be active in plasma membrane. Is expressed in several structures, including bladder; blood; cerebral cortex; gut; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in asthma. Orthologous to human C3AR1 (complement C3a receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 5.2), mammary gland adult (RPKM 4.7) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See C3ar1 in Genome Data Viewer
    Location:
    6 F2; 6 57.93 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122824099..122833116, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122847140..122856157, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5112 Neighboring gene forkhead box J2 Neighboring gene microRNA 7231 Neighboring gene STARR-seq mESC enhancer starr_17260 Neighboring gene STARR-positive B cell enhancer ABC_E2206 Neighboring gene STARR-positive B cell enhancer ABC_E687 Neighboring gene NECAP endocytosis associated 1 Neighboring gene predicted gene 5316

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement component C3a binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement component C3a receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables complement component C3a receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables complement component C3a receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement component C5a receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within_positive_effect calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in complement receptor mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in complement receptor mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glomerular mesangial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tolerance induction to nonself antigen ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    C3a anaphylatoxin chemotactic receptor
    Names
    C3a-R
    anaphylatoxin C3a receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009779.2NP_033909.1  C3a anaphylatoxin chemotactic receptor

      See identical proteins and their annotated locations for NP_033909.1

      Status: VALIDATED

      Source sequence(s)
      AK080984, BB665738, U77460
      Consensus CDS
      CCDS20504.1
      UniProtKB/Swiss-Prot
      O09047, O35951
      UniProtKB/TrEMBL
      Q5U7A4, Q8C6R2
      Related
      ENSMUSP00000048092.9, ENSMUST00000042081.9
      Conserved Domains (1) summary
      pfam00001
      Location:51428
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      122824099..122833116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)