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    Tor1b torsin family 1, member B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311854, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tor1bprovided by RGD
    Official Full Name
    torsin family 1, member Bprovided by RGD
    Primary source
    RGD:1308431
    See related
    EnsemblRapid:ENSRNOG00000006435 AllianceGenome:RGD:1308431
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity and identical protein binding activity. Predicted to be involved in endoplasmic reticulum organization. Predicted to act upstream of or within nuclear membrane organization. Predicted to be located in endoplasmic reticulum lumen and nuclear envelope. Orthologous to human TOR1B (torsin family 1 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 101.0), Kidney (RPKM 94.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tor1b in Genome Data Viewer
    Location:
    3p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34640929..34647023)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14243181..14249279)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (9792818..9798924)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene paired related homeobox 2 Neighboring gene prostaglandin E synthase Neighboring gene torsin family 1, member A Neighboring gene similar to human chromosome 9 open reading frame 78

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TorsinB--perinuclear location and association with torsinA. Hewett JW, et al. J Neurochem, 2004 Jun. PMID 15147511
    2. Immunocytochemical characterization of torsin proteins in mouse brain. Konakova M, et al. Brain Res, 2001 Dec 13. PMID 11730696
    3. Arresting a Torsin ATPase reshapes the endoplasmic reticulum. Rose AE, et al. J Biol Chem, 2014 Jan 3. PMID 24275647, Free PMC Article
    4. Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA. Jungwirth M, et al. Hum Mol Genet, 2010 Mar 1. PMID 20015956
    5. Regulation of Torsin ATPases by LAP1 and LULL1. Zhao C, et al. Proc Natl Acad Sci U S A, 2013 Apr 23. PMID 23569223, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124854

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nuclear membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    torsin-1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039197.1 → NP_001034286.1  torsin-1B precursor

      See identical proteins and their annotated locations for NP_001034286.1

      Status: PROVISIONAL

      Source sequence(s)
      BC111704
      UniProtKB/TrEMBL
      A6JU10, F7ES66, Q2M2S1
      Related
      ENSRNOP00000062610.1, ENSRNOT00000066618.5
      Conserved Domains (2) summary
      COG0542
      Location:60 → 292
      ClpA; ATP-dependent Clp protease ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones]
      pfam06309
      Location:62 → 176
      Torsin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      34640929..34647023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283960.1 → XP_063140030.1  torsin-1B isoform X1

    RNA

    1. XR_005501917.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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