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    Sec61g Sec61 translocon subunit gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689134, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sec61gprovided by RGD
    Official Full Name
    Sec61 translocon subunit gammaprovided by RGD
    Primary source
    RGD:1596170
    See related
    AllianceGenome:RGD:1596170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phospholipid binding activity; protein transmembrane transporter activity; and ribosome binding activity. Predicted to be involved in membrane docking and post-translational protein targeting to membrane, translocation. Predicted to be located in membrane. Predicted to be part of Ssh1 translocon complex. Orthologous to human SEC61G (SEC61 translocon subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 695.5), Heart (RPKM 506.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sec61g in Genome Data Viewer
    Location:
    14q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (95113083..95119458, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (90899766..90906143, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (99774589..99780964, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene COP9 signalosome complex subunit 8-like Neighboring gene V-set and transmembrane domain containing 2A Neighboring gene calcium regulated heat stable protein 1, pseudogene 1 Neighboring gene epidermal growth factor receptor Neighboring gene uncharacterized LOC134481789

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NMR conformational study of the cytoplasmic domain of the canine Sec61 gamma protein from the protein translocation pore of the endoplasmic reticulum membrane. Beswick V, et al. Biochemistry, 1996 Nov 26. PMID 8942632
    2. Evolutionary conservation of components of the protein translocation complex. Hartmann E, et al. Nature, 1994 Feb 17. PMID 8107851
    3. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Lang S, et al. J Cell Sci, 2012 Apr 15. PMID 22375059, Free PMC Article
    4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in membrane docking ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Ssh1 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein transport protein Sec61 subunit gamma
    Names
    SEC61, gamma subunit
    Sec61 translocon gamma subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135020.1 → NP_001128492.1  protein transport protein Sec61 subunit gamma

      See identical proteins and their annotated locations for NP_001128492.1

      Status: VALIDATED

      Source sequence(s)
      CB313385, CR464634, DV719731
      UniProtKB/TrEMBL
      A0A8I6AAZ9, A6JPX6, B5DEL7, B5DER8, F1LPB2
      Conserved Domains (1) summary
      cl00481
      Location:12 → 68
      SecE; SecE/Sec61-gamma subunits of protein translocation complex

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      95113083..95119458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092466.2 → XP_038948394.1  protein transport protein Sec61 subunit gamma isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAZ9, A6JPX6, B5DEL7, B5DER8, F1LPB2
      Conserved Domains (1) summary
      cl00481
      Location:12 → 68
      SecE; SecE/Sec61-gamma subunits of protein translocation complex
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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