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    Marveld2 MARVEL domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365657, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Marveld2provided by RGD
    Official Full Name
    MARVEL domain containing 2provided by RGD
    Primary source
    RGD:1306909
    See related
    EnsemblRapid:ENSRNOG00000018297 AllianceGenome:RGD:1306909
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrvldc2
    Summary
    Predicted to be involved in bicellular tight junction assembly and establishment of endothelial barrier. Predicted to act upstream of or within cell-cell junction organization and sensory perception of sound. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; basolateral plasma membrane; and tight junction. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 49. Orthologous to human MARVELD2 (MARVEL domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 83.9), Lung (RPKM 35.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Marveld2 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (33474750..33498225, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (31742652..31764150, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (30612746..30634308, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100688 Neighboring gene bolA-like 1-like Neighboring gene uncharacterized LOC102557393 Neighboring gene RAD17 checkpoint clamp loader component Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene adenylate kinase 6 Neighboring gene coiled-coil domain containing 125

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mir-203-mediated tricellulin mediates lead-induced in vitro loss of blood-cerebrospinal fluid barrier (BCB) function. Su P, et al. Toxicol In Vitro, 2015 Aug. PMID 25975750
    2. Tricellulin expression in brain endothelial and neural cells. Mariano C, et al. Cell Tissue Res, 2013 Mar. PMID 23250572
    3. Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions. Takasawa A, et al. Cell Tissue Res, 2013 Jan. PMID 23073616, Free PMC Article
    4. Evidence of tricellulin expression by immune cells, particularly microglia. Mariano C, et al. Biochem Biophys Res Commun, 2011 Jun 17. PMID 21624353
    5. Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization. Schuetz A, et al. Ann N Y Acad Sci, 2017 Oct. PMID 28661558

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tricellulin, alpha-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia.
      Title: Tricellulin, α-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia.
    2. Our study is the first to show the expression and localization of TRIC in the choroid plexus in vitro
      Title: Mir-203-mediated tricellulin mediates lead-induced in vitro loss of blood-cerebrospinal fluid barrier (BCB) function.
    3. This study reveals the presence and subcellular distribution of tricellulin in brain endothelial cells.
      Title: Tricellulin expression in brain endothelial and neural cells.
    4. the expression of tricellulin both in microglia and in the stomach immune cells point to a possible role of this new tight junctions protein in the immune system.
      Title: Evidence of tricellulin expression by immune cells, particularly microglia.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell-cell junction organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Schmidt-Lanterman incisure ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in paranodal junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in tricellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MARVEL domain-containing protein 2
    Names
    MARVEL (membrane-associating) domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108936.1 → NP_001102406.1  MARVEL domain-containing protein 2

      See identical proteins and their annotated locations for NP_001102406.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473955
      UniProtKB/TrEMBL
      A0A0G2JYJ6, A0A0G2K663, A6I595
      Related
      ENSRNOP00000100333.1, ENSRNOT00000128746.1
      Conserved Domains (2) summary
      pfam01284
      Location:185 → 361
      MARVEL; Membrane-associating domain
      pfam07303
      Location:446 → 548
      Occludin_ELL; Occludin homology domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      33474750..33498225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760680.4 → XP_008758902.1  MARVEL domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008758902.1

      UniProtKB/TrEMBL
      A0A0G2K663
      Related
      ENSRNOP00000099284.1, ENSRNOT00000131505.1
      Conserved Domains (2) summary
      pfam01284
      Location:185 → 361
      MARVEL; Membrane-associating domain
      pfam07303
      Location:450 → 548
      Occludin_ELL; Occludin homology domain

    2. XM_008760679.4 → XP_008758901.1  MARVEL domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008758901.1

      UniProtKB/TrEMBL
      A0A0G2K663
      Conserved Domains (2) summary
      pfam01284
      Location:185 → 361
      MARVEL; Membrane-associating domain
      pfam07303
      Location:450 → 548
      Occludin_ELL; Occludin homology domain

    3. XM_008760681.3 → XP_008758903.1  MARVEL domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008758903.1

      UniProtKB/TrEMBL
      A0A0G2K663
      Conserved Domains (2) summary
      pfam01284
      Location:185 → 361
      MARVEL; Membrane-associating domain
      pfam07303
      Location:450 → 548
      Occludin_ELL; Occludin homology domain
    Nucleotide Protein Strain
    Heading Accession and Version

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