Drd5 dopamine receptor D5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Drd5provided by RGD
Official Full Name: dopamine receptor D5provided by RGD
Primary source: RGD:2523
See related: EnsemblRapid:ENSRNOG00000005338 AllianceGenome:RGD:2523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: D1B
Summary: Enables G-protein alpha-subunit binding activity and dopamine neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; negative regulation of protein kinase activity; and visual learning. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in several cellular components, including brush border membrane; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and blepharospasm. Orthologous to human DRD5 (dopamine receptor D5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (76700244..76703344, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (72487950..72491050, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (77220579..77222006, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of D5 dopamine receptors in the lateral ventricle walls during post-weaning rat development.
Title: Expression of D5 dopamine receptors in the lateral ventricle walls during post-weaning rat development.
Frequency-dependency of the involvement of dopamine D1/D5 and beta-adrenergic receptors in hippocampal LTD triggered by locus coeruleus stimulation.
Title: Frequency-dependency of the involvement of dopamine D1/D5 and beta-adrenergic receptors in hippocampal LTD triggered by locus coeruleus stimulation.
Characterization of the Functional Cross-Talk between Surface GABAA and Dopamine D5 Receptors.
Title: Characterization of the Functional Cross-Talk between Surface GABA(A) and Dopamine D5 Receptors.
Results suggest that the dynamic range of D1/D5 receptor-mediated dopamine effects on LTP may be higher in ventral hippocampus than dorsal hippocampus and that ventral hippocampus may be specialized to acquire information about behaviorally relevant strong stimuli signaled by the dopamine system.
Title: Effects of endogenous and exogenous D1/D5 dopamine receptor activation on LTP in ventral and dorsal CA1 hippocampal synapses.
Findings suggest that activation of dopamine D1/5 receptors alone is sufficient to modify stimulus-induced BOLD responses in the right hippocampus and the history of previous stimulations crucially affects the impact of dopamine receptor activation on stimulus-induced BOLD responses.
Title: Late effect of dopamine D(1/5) receptor activation on stimulus-induced BOLD responses in the hippocampus and its target regions depends on the history of previous stimulations.
The results suggest that dopamine receptors in the retinal cells might actively respond to the environmental lighting to act as an important player in the activation of the dopaminergic system in the ocular structures relevant to the lighting-induced pathogenic development of myopia.
Title: Induction of dopamine D1 and D5 receptors in R28 cells by light exposures.
This study demonstrates, for the first time, that dopamine enhances duodenal permeability of control rat via D5 R
Title: Dopamine enhances duodenal epithelial permeability via the dopamine D(5) receptor in rodent.
the effect of novelty on fear extinction is dependent on dopamine D1 but not D5 receptors in the hippocampus
Title: Facilitation of fear extinction by novelty depends on dopamine acting on D1-subtype dopamine receptors in hippocampus.
low dopamine D5 receptor density in a well-established animal model for attention-deficit/hyperactivity disorder
Title: Low dopamine D5 receptor density in hippocampus in an animal model of attention-deficit/hyperactivity disorder (ADHD).
D1/5 receptor modulates intrinsic mechanisms that amplify a long depolarizing input to sustain spike firing outputs in pyramidal prefrontal cortex neurons.
Title: Contribution of dopamine d1/5 receptor modulation of post-spike/burst afterhyperpolarization to enhance neuronal excitability of layer v pyramidal neurons in prepubertal rat prefrontal cortex.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14UIA1 (e-PCR)
- UniSTS:239891

D14Arb11 (e-PCR), detects polymorphism
- UniSTS:226593

D14Mco14 (e-PCR)
- UniSTS:240168

UniSTS:166211 (e-PCR)
- UniSTS:166211

Drd5 (e-PCR), detects polymorphism
- UniSTS:166211

UniSTS:495985 (e-PCR)
- UniSTS:495985

Drd5 (e-PCR), detects polymorphism
- UniSTS:495985

D14Mgh8 (e-PCR)
- UniSTS:240329

D14Wox23 (e-PCR)
- UniSTS:239604

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables dopamine binding	IEA Inferred from Electronic Annotation more info
enables dopamine binding	ISO Inferred from Sequence Orthology more info
enables dopamine neurotransmitter receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables dopamine neurotransmitter receptor activity	ISO Inferred from Sequence Orthology more info
enables dopamine neurotransmitter receptor activity, coupled via Gs	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine neurotransmitter receptor activity, coupled via Gs	IEA Inferred from Electronic Annotation more info
enables dopamine neurotransmitter receptor activity, coupled via Gs	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in associative learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within associative learning	ISO Inferred from Sequence Orthology more info
involved_in cellular response to catecholamine stimulus	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic depression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-term synaptic depression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mating behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NAD(P)H oxidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of female receptivity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of female receptivity	ISO Inferred from Sequence Orthology more info
involved_in regulation of locomotion	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of systemic arterial blood pressure by vasopressin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by vasopressin	ISO Inferred from Sequence Orthology more info
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to amphetamine	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in sensitization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensitization	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, dopaminergic	IEA Inferred from Electronic Annotation more info
involved_in transmission of nerve impulse	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in visual learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: D(1B) dopamine receptor

Names: d(5) dopamine receptor; dopamine D5 receptor; dopamine receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.